Immobilization and Neurological Complications in Patients With Vertebral Osteomyelitis.

NCT ID: NCT04655950

Last Updated: 2020-12-07

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

250 participants

Study Classification

OBSERVATIONAL

Study Start Date

2016-02-11

Study Completion Date

2019-05-31

Brief Summary

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Vertebral osteomyelitis is an infection of the intervertebral disk and adjacent vertebral plates with a non-negligible risk of neurological complications and handicap. If there are clear recommendations dealing with antibiotic therapy and surgery indications for this pathogen, the question of the immobilization will be remaining debate. The aim of the study was to describe protocols and practices for the immobilization of vertebral osteomyelitis in different French hospitals and bone and joint infections Centers. The secondary objectives were to evaluate the frequency of neurological complications in a large prospective cohort, and to identify clinical and imaging risk factors for neurological complications.

The investigators also aim to search for association between type and duration of spine immobilization and neurological status at the end of follow-up.

Detailed Description

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Study design is descriptive, prospective, multicentric, and the investigators have a single database centralized in Nantes University Hospital. Patient's data will be conserved and trapped anonymously and patients all give oral consent. Information letter is given to each patient.

Typical study calendar :

Baseline :

* Patient information (letter and oral consent)
* Clinical data and comorbidities collection
* Neurological examination
* Spine X-ray
* MRI or CT-scan imaging to confirm diagnosis

During Hospitalization

* Date collection : spine immobilization modalities (type, duration, changes…), duration of bed rest
* Other treatments (antibiotic therapy : molecules and duration)
* Daily neurological examination

3 months follow-up visit : (if usually done by physician)
* Clinical and neurological examination
* Spine immobilization assessment
* Spine X-ray
* Oswestry questionary

6 months follow-up visit : finale visit (if usually done by physician)
* Clinical and neurological examination
* Spine immobilization assessment
* Spine X-ray
* Oswestry questionary

Conditions

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Vertebral Osteomyelitis Spondylodiscitis

Keywords

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Vertebral Osteomyelitis Spine Immobilization Neurological complications

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Interventions

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protocols and practices for the immobilization of vertebral osteomyelitis in different French hospitals and bone and joint infections Centers

Evaluation of the frequency of neurological complications in a large prospective cohort, and to identify clinical and imaging risk factors for neurological complications.

We search for association between type and duration of spine immobilization and neurological status at the end of follow-up

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Adults patients, male and female
* Hospitalized of a vertebral osteomyelitis in one of the Centers
* Meeting the criteria for the definition of vertebral Osteomyelitis (typical imaging findings)
* Microbiological proof of infection (blood culture or discovertebral biopsy) or high suspicion of infection (Compatible histology, good response to antibiotics and no differential diagnosis).

Exclusion Criteria

* Recent spinal surgery less than 1month
* Children under 18 years old
* Under guardianship
* Pregnant woman
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Nantes University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Benoit Le Goff, PH

Role: PRINCIPAL_INVESTIGATOR

Nantes University Hospital

Locations

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Angers University Hospital

Angers, , France

Site Status

Clermont ferrand University Hospital

Clermont-Ferrand, , France

Site Status

La Roche Sur Yon Hospital

La Roche-sur-Yon, , France

Site Status

Nantes University Hospital

Nantes, , France

Site Status

Paris University Hospital

Paris, , France

Site Status

Quimper Hospital

Quimper, , France

Site Status

Rennes University Hospital

Rennes, , France

Site Status

Saint-Nazaire Hospital

Saint-Nazaire, , France

Site Status

Tours University Hospital

Tours, , France

Site Status

Countries

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France

Other Identifiers

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RC16_0214

Identifier Type: -

Identifier Source: org_study_id