Relationship Between Digital Vascular Function Measured by EndoPAT® in elderlY Patients and Arterial Stiffness
NCT ID: NCT04651894
Last Updated: 2020-12-04
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
148 participants
OBSERVATIONAL
2018-05-01
2020-11-03
Brief Summary
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It is thought that arterial stiffening and endothelial dysfunction are among the earliest vascular properties altered with the onset of cardiovascular disease. Moreover aging is characterized by progressive fragmentation and break down of the elastic components of the aortic media, which are partially replaced by highly cross-linked collagen leading to stiffening, dilation, and elongation of the aorta . A major underlying mechanism of these modifications is endothelial dysfunction due to high oxidative stress and low-grade inflammation. Reactive hyperemia index (RHI), a key outcome of peripheral arterial tonometry (PAT) has recently become a reliable tool to measure microvascular endothelial function. Some studies have recently demonstrated the interest to measure in elderly patients arterial stiffness parameters in order to prevent loss of autonomy. This cross sectional study aimed at demonstrating the link between arterial stiffness evaluated by pulse wave velocity and endothelial dysfunction evaluated by RHI to implement the tools of cardio vascular risk evaluation in a population of elderly patients referred in a geriatric day hospital.
Detailed Description
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All subjects arrived in a fasting state at the geriatric day hospital where anthropometric, frailty evaluation, hemodynamic and transcutaneous measurements of aortic pulse wave velocity (AoPWV) were performed at rest. Some of them had a cerebral Magnetic resonance imaging (MRI) examination. Participants were requested not to smoke or drink tea or coffee for 30 minutes and to sit quietly for 10 minutes at least, before blood pressure and other hemodynamic parameters were measured. Individuals were considered hypertensive if they had systolic blood pressure (SBP) values \> 150 mm Hg and/or diastolic blood pressure (DBP) values \> 90 mm Hg or if they were previously diagnosed as hypertensive and treated with one or more antihypertensive drug.
Conditions
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Keywords
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Study Design
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COHORT
RETROSPECTIVE
Interventions
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reactive hyperaemia index measurement
reactive hyperaemia index with EndoPAT®
Pulse wave velocity measurement with Sphygmocor®
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* referred to a day hospital check up
* arterial stiffness evaluation
* peripheral Arterial Tonometry Evaluation
Exclusion Criteria
* poor quality of the signals
60 Years
ALL
Yes
Sponsors
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Central Hospital, Nancy, France
OTHER
Responsible Party
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Laure JOLY
Professor
Principal Investigators
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Laure Joly, Professor
Role: PRINCIPAL_INVESTIGATOR
University of Lorraine
Locations
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CHRU Nancy
Vandœuvre-lès-Nancy, Lorraine, France
Countries
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Other Identifiers
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2020PI228
Identifier Type: -
Identifier Source: org_study_id