Bone Healing in Immediate Dental Implants

NCT ID: NCT04650763

Last Updated: 2020-12-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

12 participants

Study Classification

INTERVENTIONAL

Study Start Date

2017-10-02

Study Completion Date

2018-03-30

Brief Summary

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To study the effect of platelet-rich plasma concentrate on marginal bone loss and bone mineral density in immediate implant placement through CBCT.

Detailed Description

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12 subjects were equally categorized into two groups. Group, I was the control group; whereas, the subjects in Group II received Platelet Rich Plasma (PRP) therapy. All subjects were given a standard treatment with single implant system. Inserted implants were analyzed through Cone Beam Computerized Tomography (CBCT). Records were registered at the baseline, at 12th week before functional loading and 26th week after functional loading.

Conditions

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Alveolar Bone Loss Platelet Rich Plasma

Keywords

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Dental implant, Cone Beam Computerized Tomography (CBCT).

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Control Group

Dental implant was placed in these patients following full protocol of immediate implant placement.

Group Type NO_INTERVENTION

No interventions assigned to this group

PRP Group

In this group Platelet Rich Plasma (PRP) was injected in soft tissue over surgical site.

Group Type EXPERIMENTAL

PRP injection

Intervention Type BIOLOGICAL

PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.

Automated blood cell separator to extract PRP

Intervention Type DEVICE

Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.

Interventions

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PRP injection

PRP was prepared using patient's blood and mixed with saline or mixture of calcium chloride and thrombin to form a liquid solution; in order to inject at the surgical site after placement of implant.

Intervention Type BIOLOGICAL

Automated blood cell separator to extract PRP

Blood was withdrawn from antecubital vein and mixed with anticoagulant. Blood sample was then centrifuged to obtain platelet rich plasma which was injected at surgical site after implant placement.

Intervention Type DEVICE

Other Intervention Names

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Platelet Rich Plasma injection Automated blood cell separator/ centrifuge

Eligibility Criteria

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Inclusion Criteria

* patients maintaining good oral hygiene, having adequate bone quantity at the implant site, uneventful extraction

Exclusion Criteria

* Active infection around implant site, immunocompromised state, with current major systemic disease (uncontrolled diabetes, rheumatoid arthritis, etc.) or oral pathologies, history of bleeding disorders or on anticoagulant therapy, or patients on bisphosphonates were excluded from the study
Minimum Eligible Age

20 Years

Maximum Eligible Age

50 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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CMH Lahore Medical College and Institute of Dentistry

OTHER

Sponsor Role lead

Responsible Party

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Prof. Abdul Mueed Zaigham

Professor & Head Prosthodontics Department

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Aleshba Saba khan, BDS; FCPS

Role: PRINCIPAL_INVESTIGATOR

Institute of Dentistry; CMH Lahore Medical College

Naauman Zaheer, BDS; PhD

Role: PRINCIPAL_INVESTIGATOR

Institute of Dentistry; CMH Lahore Medical College

Abdul Mueed Zaigham, BDS; FCPS

Role: STUDY_CHAIR

Institute of Dentistry; CMH Lahore Medical College

Maliha Shahbaz, BDS; MPhil

Role: STUDY_DIRECTOR

Oral Biology Department; Rashid Latif Dental College, Lahore

Usman Zaheer, BDS; FCPS

Role: PRINCIPAL_INVESTIGATOR

Lahore Medical & Dental College

Locations

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Institute of Dentistry; CMH Lahore Medical College

Lahore, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

References

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Boora P, Rathee M, Bhoria M. Effect of Platelet Rich Fibrin (PRF) on Peri-implant Soft Tissue and Crestal Bone in One-Stage Implant Placement: A Randomized Controlled Trial. J Clin Diagn Res. 2015 Apr;9(4):ZC18-21. doi: 10.7860/JCDR/2015/12636.5788. Epub 2015 Apr 1.

Reference Type RESULT
PMID: 26023636 (View on PubMed)

Khan AS, Zaheer N, Zaigham AM, Shahbaz M, Zaheer U, Alam MK. Effect of Platelet-Rich Plasma on Bone Healing in Immediate Implants Analyzed by Cone Beam Computerized Tomography: A Randomized Controlled Trial. Biomed Res Int. 2021 Mar 13;2021:6685991. doi: 10.1155/2021/6685991. eCollection 2021.

Reference Type DERIVED
PMID: 33791377 (View on PubMed)

Other Identifiers

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Case # 466/ERC/CMH/LMC

Identifier Type: -

Identifier Source: org_study_id