Higher Levothyroxine Requirements After Right-side Hemithyroidectomy
NCT ID: NCT04648722
Last Updated: 2020-12-01
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
459 participants
OBSERVATIONAL
2020-05-05
2020-06-12
Brief Summary
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Detailed Description
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Patients and Methods In a retrospective cohort study, 459 patients over the age of 18 years who underwent a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up (3-12 months post-surgery) visit at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism between 1994 and 2018 were investigated. The study was approved by the local ethics committee and performed in accordance with the Declaration of Helsinki. The work has been reported in line with the STROCSS criteria. The patients were identified via data extraction from a university hospital-wide Research, Documentation and Analysis (RDA) database. In a second step, further information necessary for the analysis (ultrasound data on pre-surgery thyroid volume, pre-surgery TSH, side and date of hemithyroidectomy, surgery protocol, underlying thyroid disease, type and dosage of treatment, age, weight, height, thyrotropin (TSH), free T4 (fT4), free T3 (fT3)) were extracted from the internal electronic health record system. Patients who had either received radiation therapy had undergone previous thyroid surgery, surgery on the contralateral lobe, had pre-existing hypothyroidism, an autoimmune disease of the thyroid or were pregnant were excluded from the analysis. 33 patients were excluded due to additional surgery on the contralateral lobe resulting in a total of 426 patients. Pre-surgery ultrasound thyroid volume was calculated with the volumetric ellipsoid method (height × width × depth × correction factor 0.524).
Conditions
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Keywords
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Study Design
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COHORT
RETROSPECTIVE
Study Groups
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Left-side hemithyroidectomy
Patients who received a hemithyroidectomy of the left thyroid lobe since 1994
Hemithyroidectomy
We investigated patients who received a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up visit (3-12 months post-surgery) at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism, Medical University of Vienna between 1994 and 2018.
Right-side hemithyroidectomy
Patients who received a hemithyroidectomy of the right thyroid lobe since 1994
Hemithyroidectomy
We investigated patients who received a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up visit (3-12 months post-surgery) at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism, Medical University of Vienna between 1994 and 2018.
Interventions
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Hemithyroidectomy
We investigated patients who received a hemithyroidectomy at the Department of General Surgery, Division of Endocrine Surgery and a follow-up visit (3-12 months post-surgery) at the thyroid outpatient clinic of the Department of Endocrinology and Metabolism, Medical University of Vienna between 1994 and 2018.
Eligibility Criteria
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Inclusion Criteria
* Males and females
* St.p. hemithyroidectomy
Exclusion Criteria
* Pregnancy
* Previous thyroid surgery (e.g. nodule removal surgery)
18 Years
ALL
No
Sponsors
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Medical University of Vienna
OTHER
Responsible Party
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Carola Deischinger
Principal investigator
Principal Investigators
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Lana Kosi-Trebotic
Role: PRINCIPAL_INVESTIGATOR
Medical University of Vienna
Locations
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Medical University of Vienna
Vienna, , Austria
Countries
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Provided Documents
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Document Type: Study Protocol and Statistical Analysis Plan
Other Identifiers
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Hemithyreoidectomy
Identifier Type: -
Identifier Source: org_study_id