Injection of Hyaluronic Acid Versus Corticosteroid for Treatment of Trigger Finger

NCT ID: NCT04645303

Last Updated: 2020-11-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

EARLY_PHASE1

Total Enrollment

100 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-11-06

Study Completion Date

2021-06-04

Brief Summary

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The aim of the study is to compare the therapeutic effects of hyaluronic acid versus steroid injections in treating trigger fingers using ultrasound guidance

Detailed Description

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A prospective randomized controlled study designed to compare the outcomes of injecting patients with trigger finger with hyaluronic acid versus corticosteroid under ultrasound guidance

Conditions

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Trigger Finger

Keywords

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Trigger finger Hyaluronic Acid Corticosteroid Ultrasound-guided injection

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Investigators Outcome Assessors

Study Groups

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Hyaluronic acid

1mL of hyaluronic acid (20 mg/2 mL; Hyalgan, Fidia, Abano Terme, Italy) infiltration at A1-Pulley under ultrasound guidance after subcutaneous 2% lidocaine without epinephrine infiltration of the skin overlying the A1-pulley.

Group Type EXPERIMENTAL

hyaluronic acid (20 mg/2 mL)

Intervention Type DRUG

A1-Pulley infiltration for trigger finger

Triamcinolone acetonide

1 mL of Triamcinolone acetonide 10mg/ml infiltration at A1-Pulley under ultrasound guidance after subcutaneous 2% lidocaine without epinephrine infiltration of the skin overlying the A1 pulley.

Group Type ACTIVE_COMPARATOR

Triamcinolone acetonide 10mg/ml

Intervention Type DRUG

A1-Pulley infiltration for trigger finger

Interventions

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hyaluronic acid (20 mg/2 mL)

A1-Pulley infiltration for trigger finger

Intervention Type DRUG

Triamcinolone acetonide 10mg/ml

A1-Pulley infiltration for trigger finger

Intervention Type DRUG

Other Intervention Names

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Hyalgan 20 mg in 2 ML Prefilled Syringe Kenalog 10 mg/ml

Eligibility Criteria

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Inclusion Criteria

* Adult (\>18 years)
* Patients with a clinical diagnosis of trigger finger grade 1-3 on the Quinnell grading scale and confirmed diagnosis by ultrasound.

Exclusion Criteria

* Quinnell's classification grade IV (contracture)
* Prior injection within 6 months
* Prior operation of the affected finger
* Presence of any contracture in the proximal interphalangeal or metacarpophalangeal joint, and
* History of diabetes, hypothyroidism, and
* Rheumatic or connective tissue disease
* Allergy to triamcinolone or hyaluronic acid
* Pregnancy
* Secondary triggering e.g. Trauma, infection
* Trigger finger symptoms duration \>6 months
Minimum Eligible Age

19 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Dubai Health Authority

OTHER_GOV

Sponsor Role lead

Responsible Party

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Sahar Said Khalil

Specialist Senior Registrar- Physical Medicine and Rehabilitation Department- Dubai Hospital- UAE( co-affiliation: Assistant Professor Rheumatology, physical Medicine and rehabilitation- Zagazig University- Egypt)

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Sahar S Khalil, SSR

Role: PRINCIPAL_INVESTIGATOR

Specialist Senior Registrar- Physical Medicine and rehabilitation Department- Dubai hospital

Mohamed M Abdulla, Consultant

Role: STUDY_CHAIR

Consultant and Head of Physical Medicine and rehabilitation Department- Dubai hospital

Locations

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Dubai Hospital- Dubai Health Authority

Dubai, , United Arab Emirates

Site Status RECRUITING

Countries

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United Arab Emirates

Central Contacts

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Sahar S Khalil, SSR

Role: CONTACT

Phone: 00971557557453

Email: [email protected]

Mohamed M Abdulla, Consultant

Role: CONTACT

Phone: 00971506584352

Email: [email protected]

Facility Contacts

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Role: primary

References

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Liu DH, Tsai MW, Lin SH, Chou CL, Chiu JW, Chiang CC, Kao CL. Ultrasound-Guided Hyaluronic Acid Injections for Trigger Finger: A Double-Blinded, Randomized Controlled Trial. Arch Phys Med Rehabil. 2015 Dec;96(12):2120-7. doi: 10.1016/j.apmr.2015.08.421. Epub 2015 Sep 1.

Reference Type BACKGROUND
PMID: 26340807 (View on PubMed)

Callegari L, Spano E, Bini A, Valli F, Genovese E, Fugazzola C. Ultrasound-guided injection of a corticosteroid and hyaluronic acid: a potential new approach to the treatment of trigger finger. Drugs R D. 2011;11(2):137-45. doi: 10.2165/11591220-000000000-00000.

Reference Type BACKGROUND
PMID: 21545190 (View on PubMed)

Abate M, Schiavone C, Salini V. The use of hyaluronic acid after tendon surgery and in tendinopathies. Biomed Res Int. 2014;2014:783632. doi: 10.1155/2014/783632. Epub 2014 May 8.

Reference Type BACKGROUND
PMID: 24895610 (View on PubMed)

Other Identifiers

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DSREC-12/2019_03

Identifier Type: -

Identifier Source: org_study_id