Effect of Consuming a Combination of Probiotic Strains and a Combination of Plant Extracts and a Probiotic Strain on the Production and Nutritional Composition of Breast Milk

NCT ID: NCT04639232

Last Updated: 2025-02-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

58 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-01-30

Study Completion Date

2022-12-31

Brief Summary

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The objective of this trial is to evaluate the effect of the consumption of a combination of probiotic strains (Prob-milk) and of a combination of plant extracts plus an inactivated probiotic strain (VoluntasProb) on the production volume and the nutritional composition and the microbiota. of breast milk in lactating women.

Detailed Description

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Previous studies have shown the galactogogue effect of fenugreek, fennel, and milk thistle. However, to date no study has considered the evaluation of all three extracts. Additionally, certain probiotic strains of Lactobacillus and Bifidobacterium also appear to increase milk production in animal studies.

The objective of this trial is to evaluate the effect of the consumption of a combination of probiotic strains (Prob-milk) and of a combination of plant extracts plus an inactivated probiotic strain (VoluntasProb) on the production volume and the nutritional composition and the microbiota. of breast milk in lactating women. This is a preliminary study whose purpose is to gather information for future studies.

Conditions

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Breast Milk Expression

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

OTHER

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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Control group

Volunteers will take 6 capsules per day for 28 days a capsule containing maltodextrin.

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DIETARY_SUPPLEMENT

Each participant will consume 6 capsules daily, 2 in every meal, without any restriction in the diet nor in their habits of life.

Prob-milk

Volunteers will take 6 capsules per day for 28 days a capsule containing the probiotics combination.

Group Type EXPERIMENTAL

Prob-milk

Intervention Type DIETARY_SUPPLEMENT

Each participant will consume 6 capsules daily, 2 in every meal, without any restriction in the diet nor in their habits of life.

Voluntas-Prob

Volunteers will take 6 capsules per day for 28 days a capsule containing the combination of plant extracts and the inactivated probiotic strain

Group Type EXPERIMENTAL

Voluntas-Prob

Intervention Type DIETARY_SUPPLEMENT

Each participant will consume 6 capsules daily, 2 in every meal, without any restriction in the diet nor in their habits of life.

Interventions

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Placebo

Each participant will consume 6 capsules daily, 2 in every meal, without any restriction in the diet nor in their habits of life.

Intervention Type DIETARY_SUPPLEMENT

Prob-milk

Each participant will consume 6 capsules daily, 2 in every meal, without any restriction in the diet nor in their habits of life.

Intervention Type DIETARY_SUPPLEMENT

Voluntas-Prob

Each participant will consume 6 capsules daily, 2 in every meal, without any restriction in the diet nor in their habits of life.

Intervention Type DIETARY_SUPPLEMENT

Eligibility Criteria

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Inclusion Criteria

1. Lactating women between 18 and 45 years old, who have given birth to a healthy baby at term (born between 37 and 42 weeks).
2. Who have the perception of having little volume of milk or a nutritional composition of milk that is not adequate for their baby
3. That they are between week 2 and week 6 of breastfeeding, and that at the time of beginning the study they are not supplementing with formula milk the feeding of their baby.
4. That they have the firm intention of breastfeeding for 28 more days.
5. Women who agree to participate and have read, understood and signed the informed consent

Exclusion Criteria

1. Suffering from any disease that may hinder or prevent breastfeeding
2. Being currently consuming or having consumed in the two weeks prior to the study a probiotic or a supplement with plant extracts.
3. Being consuming any drug that can alter the volume or composition of breast milk.
4. Have an allergy to any antibiotics or peanuts
5. Have an allergy to any of the components of the products under study
Minimum Eligible Age

18 Years

Maximum Eligible Age

45 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

Yes

Sponsors

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Biosearch S.A.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ruth Blanco Rojo, PhD

Role: PRINCIPAL_INVESTIGATOR

Biosearch S.A.

Locations

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Centro de Salud de Maracena

Maracena, Granada, Spain

Site Status

Countries

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Spain

Other Identifiers

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P047

Identifier Type: -

Identifier Source: org_study_id

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