Analysis of Retinochoroidal Vasculature in Underweight Women Using Optical Coherence Tomography Angiography
NCT ID: NCT04631978
Last Updated: 2020-11-18
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
48 participants
OBSERVATIONAL
2020-06-01
2020-08-30
Brief Summary
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Detailed Description
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According to the national guidelines, the patients are classified into two underweight groups: Group 1 consisting of those with a BMI of \<17.00 kg/m2 and Group 2 comprising those with a BMI of 17.00 to 18.49 kg/m2. The control group is formed with individuals with a normal BMI (18.50 to 24.99 kg/m2).
The right eye of each participant is included in the study. If the right eye meets any of the exclusion criteria, then the left eye is selected for the sample. The inclusion criteria for the patient group is being underweight (BMI \< 18.50 kg/m2). The exclusion criteria for all groups are as follows: refractive error \>+3.0 diopters (D) or \<-3.0 D spherical equivalent; poor image quality \<60 due to unstable fixation; IOP \> 21 mm Hg; longer AL (\>25 mm); pre-existing ophthalmic pathologies; prior ocular surgery; and a systemic chronic disease that can cause underweight or retinopathy, such as cancer, malnutrition, and diabetes mellitus.
OCTA
The imaging of all subjects is undertaken using a commercial OCTA device with a scan rate of 70,000 A-scans/s, scan beam wavelength of 840 ± 10 nm and bandwidth of 45 nm. This device can perform 70 000 A-scans/s per second to acquire volumes of 304 × 304 A-scans. All measurements are performed between 10:00 and 12:00 on the same day.
To evaluate the vascular structures, 6×6 mm OCTA software is used. The split-spectrum amplitude decorrelation angiography (SSADA) algorithm is performed in all participants. The images of poor quality (signal strength index (SSI) \< 8) with either significant motion artifact or incorrect segmentation are excluded. The OCTA images are independently graded and assessed by two retinal specialists. The software automatically segmented these full-thickness retinal scans into the superficial and deep inner retinal vascular plexuses, outer retina, and choriocapillaris (CC). The vascular density in the superficial and deep retinal vascular zones is calculated automatically by the software, and the foveal avascular zone (FAZ) and foveal density (FD) are also automatically determined. The same software also calculates the flow index rates in a central circular zone of 3.144 mm² in the outer retina and CC segments. Choroidal thickness is calculated manually by two retinal specialists, and the average value was used.
Conditions
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Study Design
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CASE_CONTROL
PROSPECTIVE
Study Groups
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Underweight
Comprehensive ophthalmologic examination
Comprehensive ophthalmologic examination
Measurements of best-corrected visual acuity, refractive error, intraocular pressure, axial length, slit lamp examination of the anterior segment, dilated fundus examination, and optical coherence tomography angiography imaging.
Control
Comprehensive ophthalmologic examination
Comprehensive ophthalmologic examination
Measurements of best-corrected visual acuity, refractive error, intraocular pressure, axial length, slit lamp examination of the anterior segment, dilated fundus examination, and optical coherence tomography angiography imaging.
Interventions
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Comprehensive ophthalmologic examination
Measurements of best-corrected visual acuity, refractive error, intraocular pressure, axial length, slit lamp examination of the anterior segment, dilated fundus examination, and optical coherence tomography angiography imaging.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* poor image quality \<60 due to unstable fixation
* IOP \> 21 mm Hg
* longer AL (\>25 mm)
* pre-existing ophthalmic pathologies
* prior ocular surgery
* a systemic chronic disease that can cause underweight or retinopathy, such as cancer, malnutrition, and diabetes mellitus.
18 Years
40 Years
ALL
Yes
Sponsors
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Akdeniz University
OTHER
Responsible Party
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Aslı Çetinkaya Yaprak
Principal Investigator
Locations
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Aslı Çentinkaya Yaprak
Antalya, , Turkey (Türkiye)
Countries
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Other Identifiers
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19102017-15/4-184
Identifier Type: -
Identifier Source: org_study_id