Effect of Oral Isotretinoin on Muscle Strength in Patients With Acne Vulgaris: A Prospective Controlled Study
NCT ID: NCT04626817
Last Updated: 2020-11-13
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
60 participants
INTERVENTIONAL
2018-09-01
2019-10-01
Brief Summary
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METHODS: This study included 30 patients who presented to our hospital and were started on oral isotretinoin treatment for acne vulgaris and 30 patients in the control group who were given local treatment. Age, gender, height and weight of the patients were recorded, and the body mass index (BMI) was calculated. The hamstring and quadriceps muscle strengths of the non-dominant side were evaluated in all patients using an isokinetic dynamometer, and the peak torque (PT) values were recorded. In the isotretinoin group, isokinetic measurements were performed again in those that completed six-month drug treatment and compared with the initial PT values.
Detailed Description
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METHODS: This study included 30 patients who presented to our hospital and were started on oral isotretinoin treatment for acne vulgaris and 30 patients in the control group who were given local treatment. Age, gender, height and weight of the patients were recorded, and the body mass index (BMI) was calculated. The hamstring and quadriceps muscle strengths of the non-dominant side were evaluated in all patients using an isokinetic dynamometer, and the peak torque (PT) values were recorded. In the isotretinoin group, isokinetic measurements were performed again in those that completed six-month drug treatment and compared with the initial PT values.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
SCREENING
NONE
Study Groups
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Isotretinoin receiving group
Isotretinoin receiving group for acne vulgaris
Isokinetic device (Biodex System 4)
The measurement of muscle strength with isokinetic device
Local treatment receiving group
Local treatment receiving group for acne vulgaris
Isokinetic device (Biodex System 4)
The measurement of muscle strength with isokinetic device
Interventions
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Isokinetic device (Biodex System 4)
The measurement of muscle strength with isokinetic device
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* receiving isotretinoin treatment for the isotretinoin group
* not having used isotretinoin within the last year for the control group
Exclusion Criteria
* uncontrolled hypertension, heart failure,
* malignancy,
* thyroid and bone diseases (e.g., hyperparathyroidism and osteomalacia),
* use of drugs that may affect skeletal metabolism (e.g., corticosteroids, heparin, and anticonvulsants),
* a history of trauma and/or surgery in the lower extremities.
* Patients who discontinued or terminated their isotretinoin treatment were not included in the study.
18 Years
45 Years
ALL
No
Sponsors
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Cevriye Mülkoğlu
OTHER
Responsible Party
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Cevriye Mülkoğlu
Medical Doctor in Department of Physical Medicine and Rehabilitation
Principal Investigators
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Cevriye Mülkoglu
Role: PRINCIPAL_INVESTIGATOR
Saglik Bakanligi Ankara Egitim ve Arastirma Hastanesi
Locations
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Ankara Training and Research Hospital
Ankara, , Turkey (Türkiye)
Countries
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References
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Mulkoglu C, Karaosmanoglu N. Effect of oral isotretinoin on muscle strength in patients with acne vulgaris: a prospective controlled study. BMC Pharmacol Toxicol. 2021 Mar 20;22(1):17. doi: 10.1186/s40360-021-00483-0.
Other Identifiers
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Ankara TRH
Identifier Type: -
Identifier Source: org_study_id