Kagocel® for the Prevention of ARVI and Influenza in Young People

NCT ID: NCT04626622

Last Updated: 2020-11-12

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

75 participants

Study Classification

OBSERVATIONAL

Study Start Date

2018-02-15

Study Completion Date

2018-06-30

Brief Summary

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This study evaluates the use of Kagocel for the prevention of acute respiratory viral infections (ARVI) and influenza during the epidemic rise in the incidence of diseases in Russia in 2018 (epidemiology: the number of cases during the period of Kagocel administration and follow-up, bacterial exacerbations, the number of repeated episodes (reinfection), demographics of patients, safety, adherence to treatment) in students at risk due to stress, lack of sleep and fatigue.

Detailed Description

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This non-interventional prospective study included 75 health students over the age of 18 who had no symptoms of acute respiratory viral infections (ARVI) and influenza at the time of inclusion and had not taken any antiviral medications to prevent ARVI and influenza for 30 days before.

The total duration of the study was 2 months: the first month participants took either Kagocel (the main group), or did not take anything at all (the control group), during the next 1 month all participants were monitored.

The diagnosis of influenza and ARVI has been confirmed in accordance with the world health organization (WHO) guidelines for the pharmacological treatment of pandemic influenza A (H1N1) 2009 and other influenza viruses. All patient examinations are conducted in accordance with local routine clinical practice and local and international standards of care.

By the study were analysed and compared those data between groups:

* demography
* anamnesis data (the incidence of ARVI and flu for previous year, the date of the lastest episode of the disease, the presence of concomitant diseases, including ENT-organs, the date of the lastest influenza vaccination).
* timelines: start of Kagocel's prevention - only for the group receiving Kagocel's prevention; start of the disease; duration of ARVI and influenza symptoms (fever, headache, runny nose, sore throat, cough); start of treatment
* symptomatic therapy (Yes/no, drug name)
* bacterial exacerbations (Yes/no)
* treatment of bacterial exacerbations (Yes/no)
* adverse events

Conditions

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Acute Upper Respiratory Tract Infection Influenza Respiratory Viral Infection

Keywords

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Influenza Acute Upper Respiratory Tract Infection acute respiratory viral infection ARVI flu cold AURI

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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ARVI and influenza prophylaxis with Kagocel (n=50)

Prophylaxis according to routine practice and instructions for medical use of Kagocel.

Group of patients receiving Kagocel for prevention of ARVI and influenza

Kagocel

Intervention Type DRUG

Investigators could prescribe other drugs in frame of routine clinical practice

ARVI and influenza prophylaxis without any antiviral medicines (n=25)

Group of patients receiving no any antiviral medicines for prevention of ARVI and influenza

No one

Intervention Type DRUG

Investigators don't prescribe any antiviral drugs in frame of routine clinical practice

Interventions

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Kagocel

Investigators could prescribe other drugs in frame of routine clinical practice

Intervention Type DRUG

No one

Investigators don't prescribe any antiviral drugs in frame of routine clinical practice

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* signed informed consent to participate in the study.
* age from 18 to 30 years.
* the subject of the study does not have symptoms of ARVI and influenza at the time of inclusion in the study.
* there are no contraindications to the use of Kagocel: pregnancy and lactation, hypersensitivity to the components of the drug, lactase deficiency, lactose intolerance, glucose-galactose malabsorption (only for the group receiving kagocel prevention).
* the subject of the study should not to take other medications to prevent colds and flu while participating in the study.
* no history of participation in a clinical trial of any drug less than 30 days prior to inclusion in this study.
* no history of treatment by interferon or interferon inducers less than 30 days prior to inclusion in this study.
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Nearmedic Plus LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Elena Tikhonova, Dr. habilitated, Professor

Role: PRINCIPAL_INVESTIGATOR

Department of infectious diseases and epidemiology of Krasnoyarsk State Medical University named after Prof. V.F.Voino-Yasenetsky

Locations

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Krasnoyarsk State Medical University

Krasnoyarsk, Krasnoyarsk Region, Russia

Site Status

Countries

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Russia

Related Links

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https://www.lvrach.ru/2018/10/15437102

Currently, great attention is paid to prevention of influenza and acute respiratory viral infections (ARVI). This article considers results of prospective observational study in prevention of influenza and ARVI among physicians \[Publication on russian\]

Other Identifiers

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version 1.0 from 21.11.2017

Identifier Type: -

Identifier Source: org_study_id