Collaborative Care Model for Allergic Rhinitis With Obstructive Sleep Apnea From Prevention to Treatment.

NCT ID: NCT04621513

Last Updated: 2020-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-07-29

Study Completion Date

2022-12-31

Brief Summary

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In this project,the investigators aim to establish a Collaborative Care Model of TCM and Western Medicine to improve the quality of life and symptoms of AR with OSA children and educate care-givers diet and massage information to improve self-care ability and alleviate anxiety for parents. In addition, the investigators will use portable oxymeter to detect the change of SpO2 and respiratory arousal index daily at home and evaluate sensitivity and specificity of portable oxymeter device applied in OSA. The investigators want to give holistic health care for participants and care-givers by this project. In addition, the investigators will build a training environment to provide medical education and training opportunity to teach medical students and clinician the knowledge of pediatric allergic rhinitis and obstructive sleep apnea by caring patients and learning from clinical cases.

Detailed Description

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Obstructive sleep apnea (OSA) affects 1-6% among children and has negative influence on day-time school performance and quality of sleep. It also cause failure to thrive,cardiovascular disease,and metabolic disease, which need early intervention. About 6% allergic rhinitis (AR) children would combine with OSA and refractory to treatment and need long-term intra-nasal corticosteroid or surgery if have moderate-severe OSA with adenoid-tonsillar hypertrophy. Some parents considering the side effect of steroid and risk of surgery will search Traditional Chinese Medicine (TCM) for help.

TCM is one kind of preventive medicine by educating people how to keep health by diet and massage. The breathing technique and "Teeth-Buckling and Salivary-Swallowing motion" noted in Inner Canon of the Yellow Emperor, one of the most important ancient Chinese medical text are compatible with myofunctional therapy for OSA. There are several studies revealed improve immune response in allergic rhinitis by TCM and severity of OSA by acupuncture.

In this project, the investigators aim to establish a Collaborative Care Model of TCM and Western Medicine to improve the quality of life and symptoms of AR with OSA children and educate care-givers diet and massage information to improve self-care ability and alleviate anxiety for parents. In addition, the investigators will use portable oxymeter to detect the change of SpO2 and respiratory arousal index daily at home and evaluate sensitivity and specificity of portable oxymeter device applied in OSA. The investigators want to give holistic health care for patients and care-givers by this project. In addition, the investigators will build a training environment to provide medical education and training opportunity to teach medical students and clinician the knowledge of pediatric allergic rhinitis and obstructive sleep apnea by caring patients and learning from clinical cases.

Conditions

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Pediatric Sleep Apnea

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Parallel Randomized controlled trial
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Collaborative Care Model of TCM and WM

Traditional Chinese Medicine(TCM):laser acupuncture and massage education. Western Medicine (WM):intra-nasal corticosteroid with singulair

Group Type EXPERIMENTAL

laser acupuncture (RJ laser S/N 1813458)

Intervention Type DEVICE

use a low-level-laser acupuncture on acupoint

western medicine

Intervention Type DRUG

Montelukast 4mg 1 tablet HS AVAMYS nasal spray 27.5μg QD

Western medicine

Western Medicine (WM):intra-nasal corticosteroid with singulair

Group Type ACTIVE_COMPARATOR

western medicine

Intervention Type DRUG

Montelukast 4mg 1 tablet HS AVAMYS nasal spray 27.5μg QD

Interventions

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laser acupuncture (RJ laser S/N 1813458)

use a low-level-laser acupuncture on acupoint

Intervention Type DEVICE

western medicine

Montelukast 4mg 1 tablet HS AVAMYS nasal spray 27.5μg QD

Intervention Type DRUG

Other Intervention Names

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intra-nasal corticosteroid(AVAMYS) with Montelukast (singulair)

Eligibility Criteria

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Inclusion Criteria

1. Age less than 18 years old
2. Patients with persistent, moderate to severe allergic rhinitis who have been diagnosed by ARIA (2014) diagnostic criteria
3. AHI by polysomnography is \>1 and diagnosis with obstructive sleep apnea.

Exclusion Criteria

1. Abnormal craniofacial structure and require surgery.
2. Patients with sleep apnea caused by muscular dysplasia of the upper respiratory tract ( eg. cerebral palsy, Down syndrome, and other congenital muscular hypoplasia).
3. Mental or behavioral abnormalities that cannot cooperate with the researcher, such as schizophrenia, depression, suicidal ideation, etc.
4. Allergy to the treatment previously
5. Any disease or organ system dysfunction that may be life-threatening
Minimum Eligible Age

6 Months

Maximum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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China Medical University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Wan-Yu Lai

Director, Division of Chinese Medicine Pediatrics

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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China Medical University & Hospital

Taichung, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Wan-Yu Lai

Role: CONTACT

Phone: 886-4-22052121

Email: [email protected]

Chang-Ching Wei

Role: CONTACT

Phone: 886-4-22052121

Email: [email protected]

Facility Contacts

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Wan-Yu Lai, MD

Role: primary

Other Identifiers

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CMUH109-REC1-089

Identifier Type: -

Identifier Source: org_study_id