Emollient Therapy In Preterm & Low Birth Weight Neonates: A Randomized Clinical Trial

NCT ID: NCT04619758

Last Updated: 2020-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

140 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-01-01

Study Completion Date

2018-06-30

Brief Summary

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The objective of this study is to assess the impact of emollient therapy on gain in weight and length among preterm and low birth weight babies.

Detailed Description

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The study will be conducted at the Department of Pediatric Medicine unit 1, KEMU / Mayo Hospital Lahore. Total of 140 neonates fulfilling the eligibility criteria will be enrolled. They will be randomly divided into two groups - A and B. Mothers of the neonates in group A will be advised massage with sunflower oil while mothers of the neonates in group B will be advised massage without any emollient. Babies will closely be followed up and their weight and length will be measured at six months of age and will be analyzed using SPSS v 23.0.

Conditions

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Weight Gain

Keywords

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Emollient Low birth weight Preterm Weight Length.

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

SUPPORTIVE_CARE

Blinding Strategy

NONE

Study Groups

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Emollient Group

Mothers of the neonates in group A will be advised massage with sunflower oil.

Group Type EXPERIMENTAL

Emollient (sunflower oil)

Intervention Type OTHER

In group A, mothers will be advised to massage their babies with sunflower oil at a dose of 10 mL/kg/day twice a day in equally divided amounts. They will be called for follow up after six months of application of sunflower oil.

Non-Emollient Group

Mothers of the neonates in group B will be advised massage without any emollient.

Group Type NO_INTERVENTION

No interventions assigned to this group

Interventions

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Emollient (sunflower oil)

In group A, mothers will be advised to massage their babies with sunflower oil at a dose of 10 mL/kg/day twice a day in equally divided amounts. They will be called for follow up after six months of application of sunflower oil.

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* Neonates of both genders
* Both breast fed and non-breast fed infants
* Neonates with birth weight between 1.5 and 2.5 kg
* Preterm neonates born between 28 and 37 completed weeks of gestation

Exclusion Criteria

* Neonates with genetic syndrome, infection or with a history of admission in NICU due to any reason will be excluded.
Minimum Eligible Age

1 Day

Maximum Eligible Age

28 Days

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Dr. Abdul Ahad Jamshaid

OTHER

Sponsor Role lead

Responsible Party

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Dr. Abdul Ahad Jamshaid

Senior Registrar

Responsibility Role SPONSOR_INVESTIGATOR

Principal Investigators

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Abdul Ahad Jamshaid, FCPS MRCPCH

Role: PRINCIPAL_INVESTIGATOR

King Edward Medical University, Lahore, Pakistan.

Locations

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King Edward Medical University

Lahore, Punjab Province, Pakistan

Site Status

Countries

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Pakistan

References

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Salam RA, Darmstadt GL, Bhutta ZA. Effect of emollient therapy on clinical outcomes in preterm neonates in Pakistan: a randomised controlled trial. Arch Dis Child Fetal Neonatal Ed. 2015 May;100(3):F210-5. doi: 10.1136/archdischild-2014-307157. Epub 2015 Jan 30.

Reference Type BACKGROUND
PMID: 25637007 (View on PubMed)

Jabraeile M, Rasooly AS, Farshi MR, Malakouti J. Effect of olive oil massage on weight gain in preterm infants: A randomized controlled clinical trial. Niger Med J. 2016 May-Jun;57(3):160-3. doi: 10.4103/0300-1652.184060.

Reference Type BACKGROUND
PMID: 27397955 (View on PubMed)

Akhavan Karbasi S, Golestan M, Fallah R, Golshan M, Dehghan Z. Effect of body massage on increase of low birth weight neonates growth parameters: A randomized clinical trial. Iran J Reprod Med. 2013 Jul;11(7):583-8.

Reference Type BACKGROUND
PMID: 24639794 (View on PubMed)

Kumar J, Upadhyay A, Dwivedi AK, Gothwal S, Jaiswal V, Aggarwal S. Effect of oil massage on growth in preterm neonates less than 1800 g: a randomized control trial. Indian J Pediatr. 2013 Jun;80(6):465-9. doi: 10.1007/s12098-012-0869-7. Epub 2012 Oct 4.

Reference Type BACKGROUND
PMID: 23054851 (View on PubMed)

Salam RA, Das JK, Darmstadt GL, Bhutta ZA. Emollient therapy for preterm newborn infants--evidence from the developing world. BMC Public Health. 2013;13 Suppl 3(Suppl 3):S31. doi: 10.1186/1471-2458-13-S3-S31. Epub 2013 Dec 20.

Reference Type BACKGROUND
PMID: 24564550 (View on PubMed)

Other Identifiers

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819/RC/KEMU

Identifier Type: -

Identifier Source: org_study_id