Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
PHASE1
46 participants
INTERVENTIONAL
2020-10-12
2020-12-30
Brief Summary
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Detailed Description
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I. On day one and day seven a blood sample will be drawn to assess chemistry (including liver function tests), C reactive protein, IgG, IgM, IL-6, erythrocyte sedimentation rates like procalcitonin, ferritin levels, and the D dimer II. Daily PCR Swabs measuring cycle threshold (CT) will be collected (days 1 - 7) III. Daily 1ml Prexablu will be placed sublingual
1. Prexablu activated for 10 minutes with Low Level Light Therapy (670 nm light) before being placed sublingually.
2. Low Level Light Therapy (NocUlite device) will be placed on wrist for 50 minutes.
Conditions
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Keywords
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Methylene blue treated group
Patients will be included in this group with the following symptoms: with at least one of the following symptoms: headache, nausea, dyspnea, myalgia, vomiting. Also that they meet the inclusion criteria
Sublingual Methylene blue
Patients will be received the treatment as follow: it will be placed Low Level Light Therapy (LLLT) NocUlite on the ventral side of the wrist on full power. Draw out 1ml of diluted Prexablu into a syringe. Activate this syringe LLLT device for 10 minutes. Then place 1ml of this activated solution of Prexablu sublingually. Patients must keep the solution under the tongue for 10 minutes before swallowing. Keep wrist pads on patients for 50 minutes.
Conventionally treated group
Patients will be included in this group with the following symptoms: with at least one of the following symptoms: headache, nausea, dyspnea, myalgia, vomiting. Also that they meet the inclusion criteria
Control patients
Control patients will be received the conventional treatment that may include analgesic, anti-inflammatory, antibiotic, steroid, antiplatelet, and anticoagulant.
Interventions
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Sublingual Methylene blue
Patients will be received the treatment as follow: it will be placed Low Level Light Therapy (LLLT) NocUlite on the ventral side of the wrist on full power. Draw out 1ml of diluted Prexablu into a syringe. Activate this syringe LLLT device for 10 minutes. Then place 1ml of this activated solution of Prexablu sublingually. Patients must keep the solution under the tongue for 10 minutes before swallowing. Keep wrist pads on patients for 50 minutes.
Control patients
Control patients will be received the conventional treatment that may include analgesic, anti-inflammatory, antibiotic, steroid, antiplatelet, and anticoagulant.
Eligibility Criteria
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Inclusion Criteria
* Of both sexes
* Confirmed case of Covid-19 (by RT-PCR) and CT less than 32 in the E
* That they go to the ER service due to COVID symptoms, and that they voluntarily agree to participate in the study by written the informed consent
* With at least 1 of the following symptoms: fever, headache, nausea, dyspnea, myalgia, vomiting, or diarrhea
* With chest X-ray without pneumonia criteria
* With SO2\> 90
* No history of allergic reaction to methylene blue
* No history of treatment with medication with methylene blue negative interaction
Exclusion Criteria
* Preadmission anticoagulation
* Severe renal insufficiency (glomerular filtration rate \<30 mL/min/1.73m2)
* Active chronic hepatitis
* Patients with history of allergic reaction or significant sensitivity to methylene blue
* Treatment with immunosuppressive agents
* Diagnosis of cancer at any stage and of any type.
* Pregnancy and breastfeeding
* Patients who plan to become pregnant during the study period or within 6 months after the end of the study period.
* Participation in another clinical trial with an experimental drug in the last 30 days.
* Other pathologies that, in the medical opinion, contraindicate participation in the study.
* Uncompensated comorbidities
18 Years
ALL
No
Sponsors
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Hospital Reg. Lic. Adolfo Lopez Mateos
OTHER_GOV
Responsible Party
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M. Eunice Rodríguez Arellano
Principal Investigator
Locations
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Hospital Regional Lic Adolfo Lopez Mateos
Mexico City, Ciudad de Mexico CDMX (Mexico City), Mexico
Countries
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Central Contacts
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Facility Contacts
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Martha E. Rodríguez Arellano, MD
Role: primary
Paula Costa Urrutia, PhD
Role: backup
References
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Wu Z, McGoogan JM. Characteristics of and Important Lessons From the Coronavirus Disease 2019 (COVID-19) Outbreak in China: Summary of a Report of 72 314 Cases From the Chinese Center for Disease Control and Prevention. JAMA. 2020 Apr 7;323(13):1239-1242. doi: 10.1001/jama.2020.2648. No abstract available.
Ji W, Wang W, Zhao X, Zai J, Li X. Cross-species transmission of the newly identified coronavirus 2019-nCoV. J Med Virol. 2020 Apr;92(4):433-440. doi: 10.1002/jmv.25682.
Baud D, Qi X, Nielsen-Saines K, Musso D, Pomar L, Favre G. Real estimates of mortality following COVID-19 infection. Lancet Infect Dis. 2020 Jul;20(7):773. doi: 10.1016/S1473-3099(20)30195-X. Epub 2020 Mar 12. No abstract available.
Backer JA, Klinkenberg D, Wallinga J. Incubation period of 2019 novel coronavirus (2019-nCoV) infections among travellers from Wuhan, China, 20-28 January 2020. Euro Surveill. 2020 Feb;25(5):2000062. doi: 10.2807/1560-7917.ES.2020.25.5.2000062.
Wang W, Xu Y, Gao R, Lu R, Han K, Wu G, Tan W. Detection of SARS-CoV-2 in Different Types of Clinical Specimens. JAMA. 2020 May 12;323(18):1843-1844. doi: 10.1001/jama.2020.3786.
Oz M, Lorke DE, Hasan M, Petroianu GA. Cellular and molecular actions of Methylene Blue in the nervous system. Med Res Rev. 2011 Jan;31(1):93-117. doi: 10.1002/med.20177.
Bradberry SM. Occupational methaemoglobinaemia. Mechanisms of production, features, diagnosis and management including the use of methylene blue. Toxicol Rev. 2003;22(1):13-27. doi: 10.2165/00139709-200322010-00003.
Barbosa P, Peters TM. The effects of vital dyes on living organisms with special reference to methylene blue and neutral red. Histochem J. 1971 Jan;3(1):71-93. doi: 10.1007/BF01686508. No abstract available.
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Lee SK, Mills A. Novel photochemistry of leuco-Methylene Blue. Chem Commun (Camb). 2003 Sep 21;(18):2366-7. doi: 10.1039/b307228b.
Khan S, Alam F, Azam A, Khan AU. Gold nanoparticles enhance methylene blue-induced photodynamic therapy: a novel therapeutic approach to inhibit Candida albicans biofilm. Int J Nanomedicine. 2012;7:3245-57. doi: 10.2147/IJN.S31219. Epub 2012 Jun 29.
Wainwright M. Methylene blue derivatives--suitable photoantimicrobials for blood product disinfection? Int J Antimicrob Agents. 2000 Dec;16(4):381-94. doi: 10.1016/s0924-8579(00)00207-7.
Tardivo JP, Del Giglio A, de Oliveira CS, Gabrielli DS, Junqueira HC, Tada DB, Severino D, de Fatima Turchiello R, Baptista MS. Methylene blue in photodynamic therapy: From basic mechanisms to clinical applications. Photodiagnosis Photodyn Ther. 2005 Sep;2(3):175-91. doi: 10.1016/S1572-1000(05)00097-9. Epub 2005 Nov 21.
Tuite EM, Kelly JM. Photochemical interactions of methylene blue and analogues with DNA and other biological substrates. J Photochem Photobiol B. 1993 Dec;21(2-3):103-24. doi: 10.1016/1011-1344(93)80173-7.
Eickmann M, Gravemann U, Handke W, Tolksdorf F, Reichenberg S, Muller TH, Seltsam A. Inactivation of Ebola virus and Middle East respiratory syndrome coronavirus in platelet concentrates and plasma by ultraviolet C light and methylene blue plus visible light, respectively. Transfusion. 2018 Sep;58(9):2202-2207. doi: 10.1111/trf.14652. Epub 2018 May 6.
Chatterjee GC, Noltmann EA. Dye-sensitized photooxidation as a tool for the elucidation of critical amino acid residues in phosphoglucose isomerase. Eur J Biochem. 1967 Jul;2(1):9-18. doi: 10.1111/j.1432-1033.1967.tb00098.x. No abstract available.
Triesscheijn M, Baas P, Schellens JH, Stewart FA. Photodynamic therapy in oncology. Oncologist. 2006 Oct;11(9):1034-44. doi: 10.1634/theoncologist.11-9-1034.
Faddy HM, Fryk JJ, Hall RA, Young PR, Reichenberg S, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Marks DC. Inactivation of yellow fever virus in plasma after treatment with methylene blue and visible light and in platelet concentrates following treatment with ultraviolet C light. Transfusion. 2019 Jul;59(7):2223-2227. doi: 10.1111/trf.15332. Epub 2019 May 3.
Fryk JJ, Marks DC, Hobson-Peters J, Watterson D, Hall RA, Young PR, Reichenberg S, Tolksdorf F, Sumian C, Gravemann U, Seltsam A, Faddy HM. Reduction of Zika virus infectivity in platelet concentrates after treatment with ultraviolet C light and in plasma after treatment with methylene blue and visible light. Transfusion. 2017 Nov;57(11):2677-2682. doi: 10.1111/trf.14256. Epub 2017 Jul 17.
Eickmann M, Gravemann U, Handke W, Tolksdorf F, Reichenberg S, Muller TH, Seltsam A. Inactivation of three emerging viruses - severe acute respiratory syndrome coronavirus, Crimean-Congo haemorrhagic fever virus and Nipah virus - in platelet concentrates by ultraviolet C light and in plasma by methylene blue plus visible light. Vox Sang. 2020 Apr;115(3):146-151. doi: 10.1111/vox.12888. Epub 2020 Jan 12.
Ziv G, Heavner JE. Permeability of the blood-milk barrier to methylene blue in cows and goats. J Vet Pharmacol Ther. 1984 Mar;7(1):55-9. doi: 10.1111/j.1365-2885.1984.tb00879.x.
Albert M, Lessin MS, Gilchrist BF. Methylene blue: dangerous dye for neonates. J Pediatr Surg. 2003 Aug;38(8):1244-5. doi: 10.1016/s0022-3468(03)00278-1.
Sills MR, Zinkham WH. Methylene blue-induced Heinz body hemolytic anemia. Arch Pediatr Adolesc Med. 1994 Mar;148(3):306-10. doi: 10.1001/archpedi.1994.02170030076017.
McFadyen I. The dangers of intra-amniotic methylene blue. Br J Obstet Gynaecol. 1992 Feb;99(2):89-90. doi: 10.1111/j.1471-0528.1992.tb14458.x. No abstract available.
Dolk H. Methylene blue and atresia or stenosis of ileum and jejunum. EUROCAT Working Group. Lancet. 1991 Oct 19;338(8773):1021-2. doi: 10.1016/0140-6736(91)91885-x. No abstract available.
van der Pol JG, Wolf H, Boer K, Treffers PE, Leschot NJ, Hey HA, Vos A. Jejunal atresia related to the use of methylene blue in genetic amniocentesis in twins. Br J Obstet Gynaecol. 1992 Feb;99(2):141-3. doi: 10.1111/j.1471-0528.1992.tb14473.x.
Iyengar B, Lal SK. Methylene blue and organised differentiation in the chick embryo. Acta Anat (Basel). 1985;123(4):220-3. doi: 10.1159/000146005.
Tiboni GM, Lamonaca D. Transplacental exposure to methylene blue initiates teratogenesis in the mouse: preliminary evidence for a mechanistic implication of cyclic GMP pathway disruption. Teratology. 2001 Oct;64(4):213-20. doi: 10.1002/tera.1066.
Other Identifiers
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064.I.2020
Identifier Type: -
Identifier Source: org_study_id