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A Comparative Study of GPI's DBS and Pallidotomy in the Treatment of Meige Syndrome

NCT ID: NCT04618887

Last Updated: 2020-11-06

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

100 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-01-01

Study Completion Date

2023-12-31

Brief Summary

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In this study, we will compare the degree of postoperative symptom improvement, postoperative complication rate, postoperative quality of life improvement degree of patients with Meige syndrome undergoing pallidotomy (unilateral globus palliotomy) and deep brain stimulation (unilateral globus pallidus) ,in order to get the conclusion of the comparison of the clinical efficacy of the two surgical plans. In addition, possible predictive factors such as age, gender, age of onset, length of disease course, scale baseline score, preoperative brain PET-CT function analysis and other possible predictive factors are added for analysis, in order to find predictive factors that can guide the choice of surgical options.

Detailed Description

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Conditions

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Meige Syndrome Meigs Syndrome Meige Disease Meig Syndrome Blepharospasm Blepharospasm of Left Eyelid Blepharospasm of Right Eyelid Blepharospasm of Both Eyelids Blepharospasm Oromandibular Dystonia

Keywords

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deep brain stimulation DBS DBNL GPi pallidotomy

Study Design

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Observational Model Type

CASE_ONLY

Study Time Perspective

RETROSPECTIVE

Study Groups

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Meige sydrome patients

pallidotomy

Intervention Type PROCEDURE

deep brain nuclei lesion of GPi

deep brain stimulation

Intervention Type PROCEDURE

deep brain stimulation of GPi

Interventions

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pallidotomy

deep brain nuclei lesion of GPi

Intervention Type PROCEDURE

deep brain stimulation

deep brain stimulation of GPi

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients confirmed Meige sydrome

Exclusion Criteria

* Patients who cannot finish the neurosurgery or the postoperative evaluation
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Peking University People's Hospital

OTHER

Sponsor Role lead

Responsible Party

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Liu Ruen

PekingUPH

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Peking University People's Hospital

Beijing, , China

Site Status

Countries

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China

Other Identifiers

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MeigeSyndrome

Identifier Type: -

Identifier Source: org_study_id