Efficacy and Safety of a New Compression System URGO BD001 in the Treatment of VLU (FREEDOM)

NCT ID: NCT04613687

Last Updated: 2020-11-03

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

52 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-30

Study Completion Date

2021-09-30

Brief Summary

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The aim of this study is to evaluate the therapeutic efficacy and the safety of the new compression system URGO BD001 in the management of venous or mixed predominantly venous leg ulcers. The therapeutic efficacy will be the reduction in wound surface area during a six weeks study treatment period.

Detailed Description

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The compression bandage URGO BD001 is indicated for the management of venous leg ulcers with ABPI (Ankle Brachial Pressure Index) ≥ 0.8, venous oedema and lymphedema justifying strong compression.

The pressure applied with the compression system URGO BD001 help to improve venous return and to reduce venous oedema. The expected clinical benefits from the compression system URGO BD001 in patient with a VLU are to increase healing rate and time to healing, and to improve patient quality of life.

Conditions

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Venous Leg Ulcer

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Prospective, multi centre, non-comparative study
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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URGOBD001

Compression bandage

Group Type EXPERIMENTAL

Compression bandage

Intervention Type DEVICE

Compression bandage URGO BD001 for the management of venous leg ulcers with ABPI (Ankle Brachial Pressure Index) ≥ 0.8, venous

Interventions

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Compression bandage

Compression bandage URGO BD001 for the management of venous leg ulcers with ABPI (Ankle Brachial Pressure Index) ≥ 0.8, venous

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Patient affected by VLU or mixed ulcer of predominantly venous origin (ankle brachial pressure index (ABPI) ≥ 0.8 and ≤ 1.3),
* Wound in granulation phase (granulation tissue ≥50%),
* Wound at least 3 cm away from any edge of another wound,
* VLU between 2 and 20 cm2 in surface area,
* VLU duration between 1 to 24 months.

Exclusion Criteria

* Patient under guardianship or protection of vulnerable adult,
* Patient with known allergy to any components of the tested compression system,
* Patient with a severe illness that might lead to premature discontinuation of the trial before the end of treatment period,
* Patient with progressive neoplastic lesions treated by radiotherapy, chemotherapy, hormone therapy or immune suppressor,
* Patient with non-controlled systemic infection by a suitable antibiotic therapy,
* Patient who had a deep vein thrombosis within 3 months prior to the inclusion,
* Patient with a lymphedema due to lymphatic obstruction,
* Diabetic patient with advanced diagnosed microangiopathy,
* Bedridden patient, or those spending less than one hour per day on their feet,
* Wound covered partially or totally with necrotic tissue,
* Clinically infected wound,
* Wound requiring surgical treatment or for which a surgery is scheduled during the study period,
* Cancerous lesions.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Laboratoires URGO

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Senet Patricia, MD

Role: PRINCIPAL_INVESTIGATOR

Vascular dermatologist, APHP, Paris, France

Dissemond Joachim, MD

Role: PRINCIPAL_INVESTIGATOR

Clinic for dermatology, Essen- Germany

Central Contacts

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Batot Géraldine, PhD

Role: CONTACT

+33 3 80 44 28 46

Tacca Olivier, PhD

Role: CONTACT

+33 3 80 44 74 22

Other Identifiers

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FI-19-09-BD001

Identifier Type: -

Identifier Source: org_study_id