The Use of Direct Puncture Technique With Mini-PCNL

NCT ID: NCT04610840

Last Updated: 2021-11-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-07-01

Study Completion Date

2022-04-01

Brief Summary

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* A single-center randomized study to evaluate the safety and effectiveness of direct puncture of the caliceal system in mini-percutaneous nephrolithotripsy.
* 60 patients
* Inclusion criteria:

1. all patients aged 18 to 70 years who are planning mini-PCNL, ready to consent to the study
2. ASA scale 1-3
3. Solitary stone up to 2.5 cm
4. Single access to the caliceal system
* Exclusion criteria:

1. Active infectious process
2. Coagulopathies
3. Abnormalities of the urinary system

Detailed Description

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All patients will be randomized into 2 groups:

Direct puncture - patients who underwent directive puncture under ultrasound or Rg control. The number of patients is 30 people.

Non-direct puncture - patients who underwent a PCS puncture with retrograde contrast. The number of patients is 30 people.

Patients will be assigned a randomization number that matches their treatment. Block randomization using 10 blocks will be performed by a central randomization organization (www.randomize.net) using a computerized algorithm.

Primary assessed indicators:

1. Gender
2. Age
3. Body mass index
4. Localization of the stone (side, pelvis, upper anterior cup, upper posterior cup, middle anterior cup, middle posterior cup, lower anterior cup, lower posterior cup)
5. Density of the stone
6. The presence of hydronephrosis

Indicators assessed during the operation - will be assessed by the physician-researcher:

1. Installation of the ureteral catheter
2. Duration of puncture
3. Puncture method (ultrasound, X-ray)
4. The success of the insertion of a flexible guidewire into the calyceal system
5. Problems during dilation of the puncture course
6. Visualization (Excellent, Moderate, Poor)
7. Type of drainage (stent, nephrostomic tube) at the end of the operation Using the Visual Analogue Pain Scale (VAS), pain assessment is planned at 2 hours, 6 hours, 12 hours and 24 hours after surgery.

In the postoperative period, the patient independently controls the intake of analgesics from the NSAID group (ketorolac 100 mg) (Patient-controlled analgesia). If the patient requires analgesics, the time of taking the drug will be recorded (pain relief on demand).

Secondary Assessment: Postoperative Assessment

1. Complications (Clavien)
2. Hemoglobin level 24 hours after surgery
3. Creatinine level 24 hours after surgery
4. Assessment of Stone-Free status after surgery by performing multislice computed tomography of the kidneys and urinary tract without intravenous contrast

Conditions

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Urolithiasis

Keywords

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urolithiasis PCNL direct puncture

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

SINGLE

Investigators

Study Groups

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Direct puncture

Direct puncture of the caliceal system performed under ultrasound or Xray control

Group Type ACTIVE_COMPARATOR

Puncture of the caliceal system

Intervention Type PROCEDURE

Puncture of the caliceal system under ultrasound/Xray control

Non-direct puncture

Puncture of the caliceal system performed under ultrasound or Xray control and retrograde contrast

Group Type ACTIVE_COMPARATOR

Puncture of the caliceal system

Intervention Type PROCEDURE

Puncture of the caliceal system under ultrasound/Xray control

Interventions

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Puncture of the caliceal system

Puncture of the caliceal system under ultrasound/Xray control

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* Patients aged 18 to 70 years who are scheduled for mini-PCNL, ready to consent to the study
* ASA scale 1-3
* Solitary kidney stone up to 2.5 cm
* One access to the caliceal system

Exclusion Criteria

* Active infectious process
* Coagulopathies
* Abnormalities of the urinary system
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Petersburg State Pavlov Medical University

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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First Pavlov Saint Petersburg University

Saint Petersburg, , Russia

Site Status RECRUITING

Countries

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Russia

Central Contacts

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Dmitry S Gorelov

Role: CONTACT

Phone: +79217964892

Email: [email protected]

Vladimir M Obidniak

Role: CONTACT

Phone: +79218944746

Email: [email protected]

Facility Contacts

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Dmitriy Gorelov, MD

Role: primary

Other Identifiers

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03/20-н

Identifier Type: -

Identifier Source: org_study_id