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The Effects of Losartan on Emotion Processing

NCT ID: NCT04606212

Last Updated: 2020-10-28

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

90 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-10

Study Completion Date

2022-03-31

Brief Summary

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The aim of the study is to investigate the effect of losartan (50mg, single dose) on salience processing

Detailed Description

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In a double-blind, between-subject, placebo-controlled design the effects of a single dose of losartan (50mg) on salience processing in healthy participants will be examined. The study will adopt a previously validated visual Oddball fMRI paradigm, starting 90 minutes after subjects receive 50mg losartan or placebo. The task requires participants to respond to emotional and novelty oddballs. Neural activity will be assessed by the acquisition of functional magnetic resonance imaging (fMRI) data.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Losartan group

Group Type EXPERIMENTAL

Losartan

Intervention Type DRUG

administration of losartan (50 mg) (oral)

Placebo group

Group Type PLACEBO_COMPARATOR

Placebo Oral Tablet

Intervention Type DRUG

administration of placebo (oral)

Interventions

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Losartan

administration of losartan (50 mg) (oral)

Intervention Type DRUG

Placebo Oral Tablet

administration of placebo (oral)

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects without past or current psychiatric or neurological disorders

Exclusion Criteria

* history of head injury
* medical or psychiatric illness
* hypertension
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Electronic Science and Technology of China

OTHER

Sponsor Role lead

Responsible Party

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Benjamin Becker

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Benjamin Becker, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Electronic Science and Technology of China

Locations

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University of Electronic Science and Technology of China

Chengdu, Sichuan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Weihua Zhao, PhD

Role: CONTACT

[email protected]
86-28-61830811

Facility Contacts

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Weihua Zhao, PhD

Role: primary

[email protected]

Other Identifiers

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UESTC-neuSCAN-73

Identifier Type: -

Identifier Source: org_study_id