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The Effects of Losartan on Reward Reinforcement Learning

NCT ID: NCT04604938

Last Updated: 2020-10-27

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

60 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-10

Study Completion Date

2022-03-31

Brief Summary

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This study aims to investigate whether a single dose of losartan (50 mg) can affect learning from positive and negative outcomes and its related neural mechanisms.

Detailed Description

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Emerging evidence suggests that the renin-angiotensin system can impact dopamine (DA) transmission and its modulatory role in reward processing. For instance, recent animal models have found that the angiotensin antagonist losartan reduces rewarding effects of methamphetamine and nicotine by modulating DA release in the striatum.The present study thus will investigate losartan effects on reward reinforcement learning and the underlying neural mechanisms. In a double-blind, between-subject, placebo-controlled design, 60 healthy male subjects will be randomly assigned to receive single-dose losartan (50 mg) or placebo, 90 minutes before performing a probabilistic reinforcement learning task during fMRI.

Conditions

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Healthy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

DOUBLE

Participants Investigators

Study Groups

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Losartan group

Drug: Losartan

Group Type EXPERIMENTAL

Losartan

Intervention Type DRUG

administration of losartan (50 mg) (oral)

Placebo group

Drug: Placebo Oral Tablet

Group Type PLACEBO_COMPARATOR

Placebo oral tablet

Intervention Type DRUG

administration of placebo (oral)

Interventions

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Losartan

administration of losartan (50 mg) (oral)

Intervention Type DRUG

Placebo oral tablet

administration of placebo (oral)

Intervention Type DRUG

Other Intervention Names

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Cozaar Oral Tablet

Eligibility Criteria

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Inclusion Criteria

* Healthy subjects without past or current psychiatric or neurological disorders
* Right-handedness
* Normal or corrected-normal version

Exclusion Criteria

* History of head injury
* Medical or psychiatric illness
* Hypertension
* General cardio-vascular alteration or diseases
* Allergy against medications
* Visual or motor impairments
* Claustrophobia
* Drug addiction
* Nicotine dependence
* FMRI contradictions
Minimum Eligible Age

18 Years

Maximum Eligible Age

30 Years

Eligible Sex

MALE

Accepts Healthy Volunteers

Yes

Sponsors

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University of Electronic Science and Technology of China

OTHER

Sponsor Role lead

Responsible Party

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Benjamin Becker

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Benjamin Becker, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Electronic Science and Technology of China

Locations

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University of Electronic Science and Technology of China

Chengdu, Sichuan, China

Site Status RECRUITING

Countries

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China

Central Contacts

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Weihua Zhao, PhD

Role: CONTACT

[email protected]
86-28-61830811

Facility Contacts

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Weihua Zhao, PhD

Role: primary

[email protected]

References

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Xu T, Zhou X, Kanen JW, Wang L, Li J, Chen Z, Zhang R, Jiao G, Zhou F, Zhao W, Yao S, Becker B. Angiotensin blockade enhances motivational reward learning via enhancing striatal prediction error signaling and frontostriatal communication. Mol Psychiatry. 2023 Apr;28(4):1692-1702. doi: 10.1038/s41380-023-02001-6. Epub 2023 Feb 21.

Reference Type DERIVED
PMID: 36810437 (View on PubMed)

Other Identifiers

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UESTC-neuSCAN-75

Identifier Type: -

Identifier Source: org_study_id