Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
NA
100 participants
INTERVENTIONAL
2020-10-15
2021-10-15
Brief Summary
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Medical expulsive therapy (MET) is recommended by the European Association of Urology (EAU) (2013) for 5-10 mm ureteric stones to facilitate stone passage. For MET, alpha blockers, mainly tamsulosin, have shown efficacy in several randomized controlled trials. The underlying pathophysiology of this therapy is supported by the presence and distribution of adrenoreceptors in the ureter. Blocking the action of alpha-1 receptors by pharmacological agents (alpha blockers), such as alfuzosin, terazosin, doxazosin, and, most typically, tamsulosin, results in the relaxation of the ureteric smooth muscle.
Ureteroscopy (URS) is the most commonly performed procedure for the treatment of ureteral calculi, with a high (\>90%) stone-free rate after a single treatment. Advancing a rigid ureteroscope into a non-dilated ureter may be difficult and cause complications. Ureteric dilatation may provide access to stones, but not in all cases, and ureteral mucosal injury up to perforation might occur.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
OTHER
SINGLE
Study Groups
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placebo group
people who given placebo to become agroup of comparison with the other group
rigid ureteroscopy
endoscopic treatment of ureteric stones by extraction or peumatic desintegration or laser
tamsulosin group
people who given tamsulosin to know the effect on ureteroscopy and compare with the control group
rigid ureteroscopy
endoscopic treatment of ureteric stones by extraction or peumatic desintegration or laser
Interventions
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rigid ureteroscopy
endoscopic treatment of ureteric stones by extraction or peumatic desintegration or laser
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Age: 18 - 75 years.
* normal renal function.
* single sided ureteral stone with normal other kideny.
* sign the informed consent.
* Be willing/able to adhere to follow up visits.
Exclusion Criteria
* renal impairment.
* Age \< 18 years or 75 \< years.
* female who were pregnant
* bilateral ureteric stone or solitary kidney.
* urinary tract infection need drainage.
18 Years
75 Years
ALL
No
Sponsors
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Assiut University
OTHER
Responsible Party
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Mahmoud Ahmed Gaber
Assistant Lecturer
Principal Investigators
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ahmed m abdel hamed
Role: STUDY_DIRECTOR
Assiut University
Locations
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Mahmoud Ahmed Gaber
Asyut, Asyut Governorate, Egypt
Countries
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Central Contacts
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Facility Contacts
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Other Identifiers
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tamsulosin and uretroscopy
Identifier Type: -
Identifier Source: org_study_id