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Application of VR-based Working Memory Screening Test

NCT ID: NCT04600726

Last Updated: 2020-10-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

160 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-02-01

Study Completion Date

2022-12-31

Brief Summary

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We propose to validate an interactive, immersive spatial memory test from the laboratory test. This VR-based working memory test (VRWMT) is a first-person, self-pacing game embedded within a virtual reality environment, the program is easily implemented with minimal instructions and no supervision that can be community-users friendly. It is specifically designed to assess rapid spatial working memory - a common deficit in all NCD subtypes. Its ability to detect pathological models of dementia, age-related deterioration, and hippocampal dysfunction are well established in literature

Detailed Description

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The proposed research aims to study the ability of VRWMT to discriminate between older adults with known mild NCD, healthy age-matched older adults and participants with non-communicable diseases and to predict their deterioration in cognitive function over a period of 12 months. Moreover, this study is to characterize and evaluate any concurrent validity between emergence of deterioration in the VRWMT and clinical tools of functional performance in older adults. Additionally, the potential of inflammatory and metabolic dysregulation biomarkers to increase our ability to detect early NCD risk over and above the predictive validity of the VRWMT. The study findings will bring both social and clinical significance to ageing and NCD research. The combination of behavioural and biomarkers of pathological significance offers an innovative approach that potentially addresses the limitations intrinsic to either measure alone.

Conditions

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Older Adults With Mild Neurocognitive Disorders Older Adults With Non-communicable Diseases Healthy Age-matched Older Adults

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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older adults with known mild NCD

Older adults with known mild neuro-cognitive disorders

no intervention

Intervention Type OTHER

no interventioni

older adults with non-communicable diseases

older adults with non-communicable diseases such as diabetics, hypertension and chronic obstructive airway diseases

no intervention

Intervention Type OTHER

no interventioni

Older adults with healthy condition

Older adults who are free from neuro-cognitive disorders and non-communicable diseases

no intervention

Intervention Type OTHER

no interventioni

Interventions

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no intervention

no interventioni

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* the ability to understand verbal and written Chinese instructions
* the ability and willingness to provide informed consent and sign the relevant document.

Exclusion Criteria

* a history of substance abuse including alcohol, drugs, or any medication/substances indicative of chronic abuse;
* participants with major NCD.
Minimum Eligible Age

65 Years

Maximum Eligible Age

80 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Department of Neuroscience, Psychology and Behavior. The University of Leicester

UNKNOWN

Sponsor Role collaborator

School of Psychology, The University of Nottingham

UNKNOWN

Sponsor Role collaborator

The Alice Ho Miu Ning Nethersole Hospital

UNKNOWN

Sponsor Role collaborator

The Hong Kong Polytechnic University

OTHER

Sponsor Role lead

Responsible Party

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Dr Frank LAI

Assistant Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Central Contacts

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Frank HY Lai, Phd

Role: CONTACT

[email protected]
91448014

References

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Daugherty AM, Raz N. A virtual water maze revisited: Two-year changes in navigation performance and their neural correlates in healthy adults. Neuroimage. 2017 Feb 1;146:492-506. doi: 10.1016/j.neuroimage.2016.09.044. Epub 2016 Sep 19.

Reference Type BACKGROUND
PMID: 27659539 (View on PubMed)

Daugherty AM, Bender AR, Yuan P, Raz N. Changes in Search Path Complexity and Length During Learning of a Virtual Water Maze: Age Differences and Differential Associations with Hippocampal Subfield Volumes. Cereb Cortex. 2016 Jun;26(6):2391-401. doi: 10.1093/cercor/bhv061. Epub 2015 Apr 1.

Reference Type BACKGROUND
PMID: 25838036 (View on PubMed)

Folley BS, Astur R, Jagannathan K, Calhoun VD, Pearlson GD. Anomalous neural circuit function in schizophrenia during a virtual Morris water task. Neuroimage. 2010 Feb 15;49(4):3373-84. doi: 10.1016/j.neuroimage.2009.11.034. Epub 2009 Dec 4.

Reference Type BACKGROUND
PMID: 19948225 (View on PubMed)

Daugherty AM, Yuan P, Dahle CL, Bender AR, Yang Y, Raz N. Path Complexity in Virtual Water Maze Navigation: Differential Associations with Age, Sex, and Regional Brain Volume. Cereb Cortex. 2015 Sep;25(9):3122-31. doi: 10.1093/cercor/bhu107. Epub 2014 May 23.

Reference Type RESULT
PMID: 24860019 (View on PubMed)

Other Identifiers

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VR_Clinical Trial

Identifier Type: -

Identifier Source: org_study_id