Sweet Taste Responsiveness in Relation to Insulin, Leptin and Adiposity Among Obese Treatment Seeking Children

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

Get a concise snapshot of the trial, including recruitment status, study phase, enrollment targets, and key timeline milestones.

Recruitment Status

WITHDRAWN

Clinical Phase

NA

Study Classification

INTERVENTIONAL

Study Start Date

2018-09-20

Study Completion Date

2019-08-02

Brief Summary

Review the sponsor-provided synopsis that highlights what the study is about and why it is being conducted.

This study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Related Clinical Trials

Explore similar clinical trials based on study characteristics and research focus.

Recording Facial Expressions to Assess Taste in Children and Teenagers

NCT02923908

Facial Expression

COMPLETED

Pancreatic Quantitative Sensory Testing (P-QST)

NCT06996535

Chronic Pancreatitis Chronic Pain Acute Recurrent Pancreatitis

ACTIVE_NOT_RECRUITING

Study to Characterize and Identify Bacteria Causing Acute Otitis Media in Young Egyptian Children

NCT01160055

Infections, Streptococcal

WITHDRAWN

The Effect of Osteopatic Cranial Techniques on the Audiometric and Tympanometric Values in Children Suffering From Otitis Media With Effusion.

NCT00547326

Otitis Media With Effusion

WITHDRAWN NA

Understanding Probability in Children

NCT00592800

Understanding Probability

TERMINATED

Detailed Description

Dive into the extended narrative that explains the scientific background, objectives, and procedures in greater depth.

Compared to healthy weight peers, some reports have shown that they are less sensitive to, or perceptive of, sucrose solutions and sweet foods, whereas others have observed the opposite pattern of findings or no difference at all. Among those seeking weight loss treatment, one investigation found perception and preferences for sweet taste remained unchanged after weight loss, and another observed a decreased ability to distinguish sweet taste from other taste solutions. Given these discrepancies in the literature, the proposed study will explore whether a relationship exists between insulin and leptin resistance, sweet taste responsiveness, and adiposity.

Conditions

See the medical conditions and disease areas that this research is targeting or investigating.

Pediatric Obesity

Study Design

Understand how the trial is structured, including allocation methods, masking strategies, primary purpose, and other design elements.

Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

Compare the level of insulin, leptin, and sweet taste sensitivity and perception before and after short term weight loss and bariatric surgery

Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

Review each arm or cohort in the study, along with the interventions and objectives associated with them.

Weight loss with bariatric surgery

Patients scheduled to undergo bariatric surgery will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI

Group Type ACTIVE_COMPARATOR

Serum insulin level

Intervention Type DIAGNOSTIC_TEST

Measure levels before and after weight loss related to bariatric surgery

Weight Loss

Patients to receive lifestyle weight loss treatment will be tested pre and post bariatric surgery. Interventions to be measured are serum Insulin and leptin levels, sweet taste responsiveness, body fat percentage, and z-BMI

Group Type ACTIVE_COMPARATOR

Serum Leptin test

Intervention Type DIAGNOSTIC_TEST

Measure levels before and after weight loss related to lifestyle change weight loss

Interventions

Learn about the drugs, procedures, or behavioral strategies being tested and how they are applied within this trial.

Serum insulin level

Measure levels before and after weight loss related to bariatric surgery

Intervention Type DIAGNOSTIC_TEST

Serum Leptin test

Measure levels before and after weight loss related to lifestyle change weight loss

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

Check the participation requirements, including inclusion and exclusion rules, age limits, and whether healthy volunteers are accepted.

Inclusion Criteria

* Patient of Children's Healthy Weigh of Buffalo
* ages of 8-14

If enrolled in the bariatric arm:

• must be scheduled for bariatric surgery prior to enrollment

Exclusion Criteria

* Patients unable to get labs drawn at a Kaleida facility
* Severe hay fever or seasonal allergies within 2 weeks of enrollment
* smoker or are exposed to second-hand smoke at home,
* has been dieting to lose weight within the past 6 months of enrollment
* currently taking any prescription medications that can influence taste or small functions or are pregnant.
* pregnancy
* Bariatric arm patients will be excluded if they fail to have the surgery.

Minimum Eligible Age

8 Years

Maximum Eligible Age

14 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No