A Multicentre, Retrospective Study to Evaluate the Outcome of HSCT Mismatch Unrelated Donors

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

61 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-07-07

Study Completion Date

2021-09-01

Brief Summary

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The primary endpoint of the study was the acute GvHD incidence, the secondary endpoints were chronic GvHD incidence, overall survival (OS), transplant related mortality (TRM) incidence, relapse incidence (RI) and neutrophil and platelets engraftment after GvHD prophylaxis with ATG-CSA-MTX or PTCy-MMF-FK506

Detailed Description

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Conditions

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Leukemia, Myeloid

Study Design

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Observational Model Type

OTHER

Study Time Perspective

RETROSPECTIVE

Interventions

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no intervention

no intervention, observational study

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* children and adults)
* HSCT from a one-antigen mismatch unrelated donors
* Treated at the Centro Trapianti Metropolitano di Torino between 2012 to 2017

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Prof. Franca Fagioli

Director

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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AOU Città della Salute e della Scienza di Torino - Presidio Infantile Regina Margherita

Turin, , Italy

Site Status

Countries

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Italy

References

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Berger M, Barone M, Spadea M, Saglio F, Pessolano R, Fagioli F. HSCT with mismatched unrelated donors: Bone marrow versus peripheral blood stem cells sources in pediatric patients. Pediatr Transplant. 2022 Jun;26(4):e14233. doi: 10.1111/petr.14233. Epub 2022 Jan 28.

Reference Type DERIVED

PMID: 35092128 (View on PubMed)

Other Identifiers

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Allo MM HSCT

Identifier Type: -

Identifier Source: org_study_id