Oncological Benefits of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients With T3-4 Gastric Cancer Cyt-

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

304 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-02-10

Study Completion Date

2029-01-10

Brief Summary

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Stomach cancer is recognized as the third leading cause of death of cancer patients worldwide. Despite the radical treatment carried out, the progression of gastric cancer occurs in 30-40% of patients. The most common type of tumor progression of this localization is peritoneal carcinomatosis. When peritoneal carcinomatosis occurs, the median survival of patients does not exceed 3 months, the overall survival is no more than 6 months. Unfortunately, when peritoneal carcinomatosis occurs, palliative chemotherapy remains the only treatment option. The modern strategy for the prevention and treatment of peritoneal carcinomatosis is based on the concept of regional chemotherapy. The main methods of regional chemotherapy are hyperthermic intraperitoneal chemotherapy (HIPEC) and Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC). PIPAC is a new technology for delivering chemotherapy drugs to tumor nodes on the surface of the peritoneum and allows the cytostatic to be evenly distributed over the abdominal cavity, increasing the depth of its penetration into tumor nodes due to the properties of aerosol and gradients of intra-abdominal and interstitial pressure. The method has a number of advantages over the HIPEC method: a large penetration depth of drugs, low trauma, the possibility of repeated use. We offer PIPAC for patients with locally advanced gastric cancer and a high risk of developing peritoneal carcinomatosis in an adjuvant mode in addition to standard treatment to prevent the development of carcinomatosis.

Detailed Description

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The study is interventional: patients over 18 years of age with an established diagnosis of stomach cancer (c)T3-4N0-3M0 CYT- will be randomized into 2 groups using the envelope method. The control group will receive only neoadjuvant chemotherapy + gastrectomy/ distal subtotal resection with D2 lymph node dissection, the active comparison group - neoadjuvant chemotherapy + gastrectomy with D2 lymph node dissection + PIPAC (Cisplatin (7.5 mg / m²) + Doxirubicin 1.5 mg / m2)). Will be assessed: overall survival, median survival, disease-free survival, quality of life of patients.

Conditions

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Peritoneal Carcinomatosis Gastric Cancer

Keywords

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Gastric cancer Aerosol Chemotherapy Regional Chemotherapy Peritoneal Carcinomatosis Peritoneal washings Intraperitoneal chemotherapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

DOUBLE

Participants Investigators

Inclusion Criteria

* Histologically confirmed, medically operable, resectable stomach adenocarcinoma (cT3-4, any N category, M0).
* No preceding cytotoxic or targeted therapy.
* No prior partial or complete tumor resection.
* Female and male patient ≥ 18 and ≤ 75 years. Female patient with childbearing potential needs to have a negative pregnancy test within 7 days prior to study start. Males and females of reproductive potential must agree to practice highly effective contraceptive measures\* during the study. Male patients must also agree to refrain from father a child during treatment and additionally to use a condom during treatment period. Their female partner of childbearing potential must also agree to use an adequate contraceptive measure.

\*highly effective (i.e. failure rate of \<1% per year when used consistently and correctly) methods: intravaginal and transdermal combined (estrogen and progestogen containing) hormonal contraception; injectable and implantable progestogen-only hormonal contraception; intrauterine device (IUD); intrauterine hormone-releasing system (IUS); bilateral tubal occlusion; vasectomised partner; sexual abstinence (complete abstinence is defined as refraining from heterosexual intercourse during the entire period of risk associated with the study treatments).
* ECOG = 0-2.
* Exclusion of distant metastases by CT or MRI of abdomen, pelvis, and thorax, bone scan or MRI (if bone metastases are suspected due to clinical signs). Exclusion of the infiltration of any adjacent organs or structures by CT or MRI.
* Laparoscopic exclusion of peritoneal carcinomatosis at initial staging, before start of FLOT chemotherapy
* Adequate hematological, hepatic and renal function parameters:

Leukocytes ≥ 3000/mm³, platelets ≥ 100,000/mm³, neutrophil count (ANC) ≥1000/µL Serum creatinine ≤ 1.5 x upper limit of normal Bilirubin ≤ 1.5 x upper limit of normal, AST and ALT ≤ 3.0 x upper limit of normal, alkaline phosphatase ≤ 6 x upper limit of normal For patients not receiving therapeutic anticoagulation: INR or aPTT ≤ 1.5 x ULN; for patients receiving therapeutic anticoagulation: stable anticoagulant regimen.

* Patient able and willing to provide written informed consent and to comply with the study protocol and with the planned surgical procedures.

Exclusion Criteria

* Patient without neoadjuvant therapy or those who received a neoadjuvant therapy other than FLOT.
* Known hypersensitivity against 5-FU, leucovorin, oxaliplatin, or docetaxel.
* Other known contraindications against, 5-FU, leucovorin, oxaliplatin, or docetaxel.
* Clinically significant active coronary heart disease, cardiomyopathy or congestive heart failure, NYHA III-IV.
* Clinically significant valvular defect.
* Criteria of primary unresectability, e.g.:

Radiologically documented evidence of major blood vessel invasion or invasion of adjacent organs (T4b).

Patients with involved retroperitoneal (e.g. para-aortal, paracaval or interaortocaval lymph nodes) or mesenterial lymph nodes (distant metastases!).

* Other severe internal disease or acute infection.
* Peripheral polyneuropathy ≥ NCI Grade II.
* Patient has undergone major surgery within 28 days prior to enrollment except staging laparoscopy.
* Cirrhosis at a level of Child-Pugh B (or worse) or cirrhosis (any degree) and a history of hepatic encephalopathy or ascites.
* On-treatment participation in another interventional clinical study in the period 30 days prior to inclusion and during the study.
* Patient pregnant or breast feeding, or planning to become pregnant.
* Any other concurrent antineoplastic treatment including irradiation.

Minimum Eligible Age

18 Years

Maximum Eligible Age

65 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Alexander Zakharenko, PhD

Role: PRINCIPAL_INVESTIGATOR

First Pavlov State Medical University of St. Petersburg

Ilya Vervekin

Role: STUDY_CHAIR

First Pavlov State Medical University of St. Petersburg

Locations

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First Pavlov State Medical University of St. Petersburg

Saint Petersburg, , Russia

Site Status RECRUITING

Countries

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Russia

Central Contacts

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Alexander Zakharenko, PhD

Role: CONTACT

Phone: 9219516183

Email: [email protected]

Michael Belyaev, PhD

Role: CONTACT

Phone: 89218628926

Email: [email protected]

Facility Contacts

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Ilya Vervekin

Role: primary

Other Identifiers

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1-AbOn-2020

Identifier Type: -

Identifier Source: org_study_id

Oncological Benefits of Pressured Intraperitoneal Aerosol Chemotherapy (PIPAC) in Patients With T3-4 Gastric Cancer Cyt-

Study Results

Basic Information

Brief Summary

Detailed Description

Conditions

Keywords

Study Design

Study Groups

PIPAC group

Staging laparoscopy

5-Fluorouracil

Leucovorin

Oxaliplatin

Docetaxel

Radical surgery

PIPAC

Adjuvant chemotherapy

Control group

Staging laparoscopy

5-Fluorouracil

Leucovorin

Oxaliplatin

Docetaxel

Radical surgery

Adjuvant chemotherapy

Interventions

Staging laparoscopy

5-Fluorouracil

Leucovorin

Oxaliplatin

Docetaxel

Radical surgery

PIPAC

Adjuvant chemotherapy

Other Intervention Names

Eligibility Criteria

Inclusion Criteria

Exclusion Criteria

Sponsors

St. Petersburg State Pavlov Medical University

Responsible Party

Principal Investigators

Alexander Zakharenko, PhD

Ilya Vervekin

Locations

First Pavlov State Medical University of St. Petersburg

Countries

Central Contacts

Alexander Zakharenko, PhD

Michael Belyaev, PhD

Facility Contacts

Ilya Vervekin

Other Identifiers

1-AbOn-2020