A Study of Belzutifan (MK-6482) in Combination With Lenvatinib Versus Cabozantinib for Treatment of Renal Cell Carcinoma (MK-6482-011)

NCT ID: NCT04586231

Last Updated: 2025-04-02

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

ACTIVE_NOT_RECRUITING

Clinical Phase

PHASE3

Total Enrollment

708 participants

Study Classification

INTERVENTIONAL

Study Start Date

2021-02-25

Study Completion Date

2027-02-11

Brief Summary

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This study will compare the efficacy and safety of belzutifan + lenvatinib versus cabozantinib in participants with advanced renal cell carcinoma (RCC) with clear cell component after prior therapy.

The primary hypothesis is that belzutifan + lenvatinib is superior to cabozantinib in terms of progression-free survival or overall survival.

Detailed Description

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Conditions

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Carcinoma, Renal Cell

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Belzutifan + Lenvatinib

Belzutifan 120 mg and lenvatinib 20 mg orally once a day

Group Type EXPERIMENTAL

Belzutifan

Intervention Type DRUG

Immediate-release 40 mg tablet

Lenvatinib

Intervention Type DRUG

Capsule available in 4 mg and 10 mg dosages

Cabozantinib

Cabozantinib 60 mg orally once a day

Group Type ACTIVE_COMPARATOR

Cabozantinib

Intervention Type DRUG

Tablet available in 20 mg, 40 mg and 60 mg dosages

Interventions

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Belzutifan

Immediate-release 40 mg tablet

Intervention Type DRUG

Lenvatinib

Capsule available in 4 mg and 10 mg dosages

Intervention Type DRUG

Cabozantinib

Tablet available in 20 mg, 40 mg and 60 mg dosages

Intervention Type DRUG

Other Intervention Names

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PT2977 MK-6482 WELIREG™ Lenvima E7080 MK-7902 Cabometyx Cometriq XL184 BMS-907351

Eligibility Criteria

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Inclusion Criteria

* Unresectable, locally advanced or metastatic clear cell renal cell carcinoma (RCC).
* Disease progression on or after an anti-programmed cell death-1/ligand 1 (PD-1/L1) therapy as either first or second-line treatment for locally advanced/metastatic RCC or as adjuvant treatment or neoadjuvant/adjuvant with progression on or within 6 months of last dose.
* Measurable disease per RECIST 1.1 criteria as assessed by local study investigator.
* Karnofsky performance status (KPS) score of at least 70% assessed within 10 days before randomization.
* Received no more than 2 prior systemic regimens including: one anti-PD-1/L1 containing adjuvant or neoadjuvant/adjuvant regimens with progression on or within 6 months from the last dose of that regimen OR one or 2 regimens for locoregional/advanced disease
* Received only 1 prior antiPD-1/L1 therapy for adjuvant, neoadjuvant/adjuvant or locally advanced/metastatic RCC.
* A male participant is eligible to participate if he is abstinent from heterosexual intercourse or agrees to use contraception during the intervention period and for at least 7 days after the last dose of belzutifan or lenvatinib in the belzutifan+lenvatinib arm, whichever occurs last, and 23 days after the last dose of cabozantinib.
* A female participant is eligible to participate if they are not pregnant, not breastfeeding, and at least 1 of the following conditions applies: Not a woman of childbearing potential (WOCBP) or a WOCBP who agrees to follow the contraceptive guidance during the intervention period and for at least 30 days after the last dose of study intervention in the belzutifan+ lenvatinib arm, or 120 days after the last dose of study intervention in the cabozantinib arm.
* Adequately controlled blood pressure.
* Adequate organ function.

Exclusion Criteria

* A pulse oximeter reading \<92% at rest, requires intermittent supplemental oxygen, or requires chronic supplemental oxygen.
* Known additional malignancy that is progressing or has required active treatment within the past 3 years except for basal cell carcinoma of the skin, squamous cell carcinoma of the skin, or carcinoma in situ (eg, breast carcinoma, cervical cancer in situ) that have undergone potentially curative therapy.
* Known central nervous system (CNS) metastases and/or carcinomatous meningitis.
* Clinically significant cardiac disease within 6 months of first dose of study intervention.
* Prolongation of QTc interval to \>480 ms.
* Symptomatic pleural effusion (e.g.,cough, dyspnea, pleuritic chest pain) that is not clinically stable.
* Pre-existing ≥Grade 3 gastrointestinal or nongastrointestinal fistula.
* Moderate to severe hepatic impairment.
* History of significant bleeding within 3 months before randomization.
* History of solid organ transplantation.
* Known psychiatric or substance abuse disorder that would interfere with cooperation with the requirements of the study.
* Unable to swallow orally administered medication or has a gastrointestinal disorder affecting absorption (e.g., gastrectomy, partial bowel obstruction, malabsorption).
* Known hypersensitivity or allergy to the active pharmaceutical ingredients or any component of the study intervention formulations.
* Received colony-stimulating factors \[eg, granulocyte colony-stimulating factor (G-CSF), granulocyte macrophage colony-stimulating factor (GMCSF) or recombinant erythropoietin (EPO)\] within 28 days before randomization.
* Prior treatment with belzutifan or another hypoxia-inducible factor (HIF)-2α inhibitor.
* Prior treatment with lenvatinib.
* Prior treatment with cabozantinib.
* Currently participating in a study of an investigational agent or using an investigational device.
* Active infection requiring systemic therapy.
* History of human immunodeficiency virus (HIV) infection.
* History of hepatitis B or known active hepatitis C infection.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Eisai Inc.

INDUSTRY

Sponsor Role collaborator

Merck Sharp & Dohme LLC

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Medical Director

Role: STUDY_DIRECTOR

Merck Sharp & Dohme LLC

Locations

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Ironwood Cancer & Research Centers ( Site 0077)

Chandler, Arizona, United States

Site Status

Cedars Sinai Medical Center ( Site 0027)

Los Angeles, California, United States

Site Status

UCLA Hematology/Oncology - Santa Monica ( Site 0048)

Los Angeles, California, United States

Site Status

St. Joseph Hospital-The Center for Cancer Prevention and Treatment ( Site 0095)

Orange, California, United States

Site Status

UC Irvine Health ( Site 0029)

Orange, California, United States

Site Status

Providence Saint John's Health Center ( Site 0083)

Santa Monica, California, United States

Site Status

Georgetown University Medical Center ( Site 0006)

Washington D.C., District of Columbia, United States

Site Status

AdventHealth Orlando-AdventHealth Medical Group Hematology & Oncology at Orlando ( Site 0003)

Orlando, Florida, United States

Site Status

Orlando Health, Inc. ( Site 0035)

Orlando, Florida, United States

Site Status

University Cancer & Blood Center, LLC ( Site 0057)

Athens, Georgia, United States

Site Status

Emory University Hospital ( Site 0012)

Atlanta, Georgia, United States

Site Status

Rush University Medical Center ( Site 0040)

Chicago, Illinois, United States

Site Status

Illinois Cancer Care, PC ( Site 0008)

Peoria, Illinois, United States

Site Status

Parkview Cancer Institute ( Site 0088)

Fort Wayne, Indiana, United States

Site Status

Norton Cancer Institute - St. Matthews ( Site 0065)

Louisville, Kentucky, United States

Site Status

Tulane University School of Medicine ( Site 0098)

New Orleans, Louisiana, United States

Site Status

Lahey Hospital & Medical Center ( Site 0090)

Burlington, Massachusetts, United States

Site Status

Cancer & Hematology Centers of Western Michigan ( Site 0018)

Grand Rapids, Michigan, United States

Site Status

HealthPartners Cancer Research Center-HealthPartners Frauenshuh Cancer Center ( Site 0005)

Saint Louis Park, Minnesota, United States

Site Status

University of Mississippi Medical Ctr ( Site 0037)

Jackson, Mississippi, United States

Site Status

Cancer Partners of Nebraska ( Site 0086)

Lincoln, Nebraska, United States

Site Status

Rutgers Cancer Institute of New Jersey ( Site 0078)

New Brunswick, New Jersey, United States

Site Status

R.J. Zuckerberg Cancer Center-Medical Oncology ( Site 0013)

Lake Success, New York, United States

Site Status

Memorial Sloan Kettering Cancer Center ( Site 0055)

New York, New York, United States

Site Status

Levine Cancer Institute ( Site 0004)

Charlotte, North Carolina, United States

Site Status

Duke Cancer Institute ( Site 0096)

Durham, North Carolina, United States

Site Status

Lehigh Valley Hospital- Cedar Crest-Oncology Clinical Trials ( Site 0056)

Allentown, Pennsylvania, United States

Site Status

University of Texas, Southwestern Medical Center ( Site 0015)

Dallas, Texas, United States

Site Status

Huntsman Cancer Institute-HCI Clinical Trials Office ( Site 7001)

Salt Lake City, Utah, United States

Site Status

University of Vermont Medical Center ( Site 0001)

Burlington, Vermont, United States

Site Status

Blue Ridge Cancer Care - Roanoke ( Site 0043)

Roanoke, Virginia, United States

Site Status

Seattle Cancer Care Alliance-Renal/Melanoma/MCC ( Site 0093)

Seattle, Washington, United States

Site Status

Confluence Health | Wenatchee Valley Hospital & Clinics ( Site 0061)

Wenatchee, Washington, United States

Site Status

Centro de Urología (CDU) ( Site 0803)

CABA, Buenos Aires, Argentina

Site Status

Hospital Británico de Buenos Aires-Oncology ( Site 0801)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Site Status

Instituto Alexander Fleming ( Site 0800)

Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Site Status

Sanatorio Británico-Clinical Oncology Department ( Site 0802)

Rosario, Santa Fe Province, Argentina

Site Status

Sanatorio Parque ( Site 0806)

Rosario, Santa Fe Province, Argentina

Site Status

Asociación de Beneficencia Hospital Sirio Libanés ( Site 0804)

Buenos Aires, , Argentina

Site Status

GenesisCare North Shore ( Site 4011)

St Leonards, New South Wales, Australia

Site Status

Lyell McEwin Hospital ( Site 4004)

Elizabeth Vale, South Australia, Australia

Site Status

Peninsula Health Frankston Hospital ( Site 4001)

Frankston, Victoria, Australia

Site Status

Peter MacCallum Cancer Centre-Parkville Cancer Clinical Trials Unit (PCCTU) ( Site 4010)

Melbourne, Victoria, Australia

Site Status

Medizinische Universitätsklinik Graz ( Site 1051)

Graz, Styria, Austria

Site Status

Ordensklinikum Linz GmbH Elisabethinen-Urologie ( Site 1001)

Linz, Upper Austria, Austria

Site Status

Klinik Ottakring-1.Medizinische Abteilung - Zentrum für Onkologie und Hämatologie ( Site 1031)

Vienna, Vienna, Austria

Site Status

Krankenhaus der Barmherzigen Brüder Wien ( Site 1041)

Vienna, , Austria

Site Status

Medizinische Universität Wien ( Site 1021)

Vienna, , Austria

Site Status

Institut Jules Bordet ( Site 1103)

Anderlecht, Bruxelles-Capitale, Region de, Belgium

Site Status

Cliniques Universitaires Saint Luc - Bruxelles ( Site 1105)

Brussels, Bruxelles-Capitale, Region de, Belgium

Site Status

Grand Hopital de Charleroi ( Site 1104)

Charleroi, Hainaut, Belgium

Site Status

UZ Gent ( Site 1100)

Ghent, Oost-Vlaanderen, Belgium

Site Status

UZ Leuven ( Site 1101)

Leuven, Vlaams-Brabant, Belgium

Site Status

CHU de Liege ( Site 1102)

Liège, , Belgium

Site Status

Liga Norte Riograndense Contra o Cancer ( Site 0313)

Natal, Rio Grande do Norte, Brazil

Site Status

Centro Gaucho Integrado de Oncologia ( Site 0304)

Porto Alegre, Rio Grande do Sul, Brazil

Site Status

BP - A Beneficencia Portuguesa de São Paulo-Medical Oncology ( Site 0311)

São Paulo, , Brazil

Site Status

Hospital Paulistano - Amil Clinical Research ( Site 0308)

São Paulo, , Brazil

Site Status

Tom Baker Cancer Centre ( Site 0109)

Calgary, Alberta, Canada

Site Status

Cross Cancer Institute ( Site 0111)

Edmonton, Alberta, Canada

Site Status

BC Cancer Vancouver-Clinical Trials Unit ( Site 0110)

Vancouver, British Columbia, Canada

Site Status

The Moncton Hospital ( Site 0101)

Moncton, New Brunswick, Canada

Site Status

Hamilton Health Sciences-Juravinski Cancer Centre ( Site 0114)

Hamilton, Ontario, Canada

Site Status

Kingston Health Sciences Centre ( Site 0105)

Kingston, Ontario, Canada

Site Status

The Ottawa Hospital - General Campus-The Ottawa Hospital Cancer Centre ( Site 0116)

Ottawa, Ontario, Canada

Site Status

Sunnybrook Health Sciences - Odette Cancer Centre ( Site 0113)

Toronto, Ontario, Canada

Site Status

CISSS de la Monteregie-Centre ( Site 0103)

Greenfield Park, Quebec, Canada

Site Status

Centre intégré de cancérologie du CHU de Québec Université Laval, Hôpital de l'Enfant-Jésus ( Site 0

Québec, Quebec, Canada

Site Status

CIUSSS de l Estrie - CHUS - Centre Hosp. Univ. Sherbrooke ( Site 0102)

Sherbrooke, Quebec, Canada

Site Status

Bradfordhill-Clinical Area ( Site 0400)

Santiago, Region M. de Santiago, Chile

Site Status

James Lind Centro de Investigación del Cáncer ( Site 0402)

Temuco, Región de la Araucanía, Chile

Site Status

Fundación Colombiana de Cancerología Clínica Vida ( Site 0505)

Medellín, Antioquia, Colombia

Site Status

Sociedad De Oncologia Y Hematologia Del Cesar-Oncology ( Site 0508)

Valledupar, Cesar Department, Colombia

Site Status

Instituto Nacional de Cancerología-Clinical Oncology ( Site 0500)

Bogotá, Cundinamarca, Colombia

Site Status

Fundación Cardiovascular de Colombia ( Site 0501)

Piedecuesta, Santander Department, Colombia

Site Status

Masarykuv onkologicky ustav-Klinika komplexni onkologicke pece ( Site 2203)

Brno, Brno-mesto, Czechia

Site Status

Nemocnice České Budějovice-Onkologicke oddeleni ( Site 2204)

České Budějovice, Jihočeský kraj, Czechia

Site Status

Fakultni Thomayerova nemocnice-Onkologicka klinika 1. LF UK ( Site 2200)

Prague, Praha 4, Czechia

Site Status

Fakultni nemocnice v Motole-Onkologicka klinika 2. LF UK a FN Motol ( Site 2205)

Prague, Praha 5, Czechia

Site Status

Fakultni nemocnice Hradec Kralove-Klinika onkologie a radioterapie ( Site 2201)

Hradec Králové, , Czechia

Site Status

Tampereen yliopistollinen sairaala ( Site 1801)

Tampere, Pirkanmaa, Finland

Site Status

TYKS ( Site 1802)

Turku, Southwest Finland, Finland

Site Status

HYKS ( Site 1800)

Helsinki, Uusimaa, Finland

Site Status

Institut Jean Godinot ( Site 1216)

Reims, Ain, France

Site Status

Centre Antoine Lacassagne ( Site 1217)

Nice, Alpes-Maritimes, France

Site Status

Institut de cancérologie Strasbourg Europe (ICANS) ( Site 1218)

Strasbourg, Alsace, France

Site Status

CHU de Bordeaux- Hopital Saint Andre ( Site 1209)

Bordeaux, Gironde, France

Site Status

Institut Claudius Regaud ( Site 1215)

Toulouse, Haute-Garonne, France

Site Status

Clinique Francois Chenieux ( Site 1210)

Limoges, Haute-Vienne, France

Site Status

Institut de Cancerologie de l Ouest Centre Rene Gauducheau ( Site 1201)

Saint-Herblain, Loire-Atlantique, France

Site Status

Institut de Cancerologie de l Ouest Site Paul Papin ( Site 1200)

Angers, Maine-et-Loire, France

Site Status

Hopital Tenon ( Site 1213)

Paris, , France

Site Status

Klinik fuer Urologie ( Site 1303)

Freiburg im Breisgau, Baden-Wurttemberg, Germany

Site Status

NCT-Department of Medical Oncology ( Site 1320)

Heidelberg, Baden-Wurttemberg, Germany

Site Status

Klinikum Nuernberg Nord ( Site 1300)

Nuremberg, Bavaria, Germany

Site Status

Universitaetsklinikum Frankfurt ( Site 1301)

Frankfurt am Main, Hesse, Germany

Site Status

Universitaetsklinikum Aachen AOER ( Site 1317)

Aachen, North Rhine-Westphalia, Germany

Site Status

Universitaetsklinikum des Saarlandes ( Site 1305)

Homburg/ Saar, Saarland, Germany

Site Status

Krankenhaus Martha Maria Halle-Doelau ( Site 1314)

Halle, Saxony-Anhalt, Germany

Site Status

Helios Klinikum Erfurt GmbH ( Site 1315)

Erfurt, Thuringia, Germany

Site Status

Charite Universitaetsmedizin Berlin ( Site 1321)

Berlin, , Germany

Site Status

HELIOS Klinikum Berlin-Buch ( Site 1311)

Berlin, , Germany

Site Status

UNIVERSITY HOSPITAL OF PATRAS-DIVISION OF ONCOLOGY ( Site 3302)

Pátrai, Achaia, Greece

Site Status

Alexandra General Hospital of Athens-ONCOLOGY DEPT. ( Site 3304)

Athens, Attica, Greece

Site Status

Athens Medical Center ( Site 3303)

Athens, Attica, Greece

Site Status

ATTIKON GENERAL UNIVERSITY HOSPITAL ( Site 3301)

Chaïdári, Attica, Greece

Site Status

European Interbalkan Medical Center-Oncology Department ( Site 3300)

Thessaloniki, , Greece

Site Status

Mater Misericordiae University Hospital ( Site 3201)

Dublin, Dublin, Ireland

Site Status

Tallaght University Hospital ( Site 3200)

Dublin, , Ireland

Site Status

Mater Private Hospital - Dublin ( Site 3202)

Dublin, , Ireland

Site Status

Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori ( Site 1407)

Meldola, Forli-Cesena, Italy

Site Status

Istituto Clinico Humanitas Research Hospital ( Site 1406)

Rozzano, Milano, Italy

Site Status

Ospedale San Luigi Gonzaga ( Site 1405)

Orbassano, Torino, Italy

Site Status

Medical Oncology Ospedale San Donato ( Site 1404)

Arezzo, , Italy

Site Status

Azienda Ospedaliera Policlinico di Bari ( Site 1402)

Bari, , Italy

Site Status

IRCCS Ospedale San Raffaele ( Site 1409)

Milan, , Italy

Site Status

Fondazione IRCCS Istituto Nazionale dei Tumori di Milano ( Site 1400)

Milan, , Italy

Site Status

Istituti Clinici Scientifici Maugeri Spa ( Site 1403)

Pavia, , Italy

Site Status

Fondazione Policlinico Universitario Agostino Gemelli-Medical Oncology ( Site 1410)

Roma, , Italy

Site Status

Azienda Ospedaliera S. Maria di Terni ( Site 1401)

Terni, , Italy

Site Status

Ospedale Maggiore Borgo Trento ( Site 1408)

Verona, , Italy

Site Status

Fujita Health University ( Site 5003)

Toyoake, Aichi-ken, Japan

Site Status

National Cancer Center Hospital East ( Site 5000)

Kashiwa, Chiba, Japan

Site Status

Toho University Sakura Medical Center ( Site 5014)

Sakura, Chiba, Japan

Site Status

Sapporo Medical University Hospital ( Site 5008)

Sapporo, Hokkaido, Japan

Site Status

Kobe City Medical Center General Hospital ( Site 5017)

Kobe, Hyōgo, Japan

Site Status

Yokohama City University Hospital ( Site 5007)

Yokohama, Kanagawa, Japan

Site Status

Nara Medical University Hospital ( Site 5002)

Kashihara, Nara, Japan

Site Status

Kindai University Hospital- Osakasayama Campus-Urology ( Site 5010)

Sayama, Osaka, Japan

Site Status

Osaka University Hospital ( Site 5012)

Suita, Osaka, Japan

Site Status

Hamamatsu University School of Medicine University Hospital ( Site 5004)

Hamamatsu, Shizuoka, Japan

Site Status

Tokyo Medical and Dental University Hospital ( Site 5009)

Bunkyo-ku, Tokyo, Japan

Site Status

Toranomon Hospital ( Site 5001)

Minato-ku, Tokyo, Japan

Site Status

Kyushu University Hospital ( Site 5005)

Fukuoka, , Japan

Site Status

Niigata University Medical & Dental Hospital ( Site 5013)

Niigata, , Japan

Site Status

Osaka International Cancer Institute ( Site 5016)

Osaka, , Japan

Site Status

Nippon Medical School Hospital ( Site 5006)

Tokyo, , Japan

Site Status

Tokyo Women's Medical University Adachi Medical Center ( Site 5015)

Tokyo, , Japan

Site Status

Keio university hospital ( Site 5011)

Tokyo, , Japan

Site Status

Zuyderland Medical Centre-Trialbureau Interne Geneeskunde ( Site 1904)

Sittard-Geleen, Limburg, Netherlands

Site Status

Amphia Hospital Location Molengracht ( Site 1912)

Breda, North Brabant, Netherlands

Site Status

Antoni van Leeuwenhoek Ziekenhuis ( Site 1901)

Amsterdam, North Holland, Netherlands

Site Status

Medisch Centrum Leeuwarden ( Site 1905)

Leeuwarden, Provincie Friesland, Netherlands

Site Status

Erasmus MC ( Site 1913)

Rotterdam, South Holland, Netherlands

Site Status

Franciscus Gasthuis & Vlietland, Locatie Vlietland ( Site 1909)

Schiedam, South Holland, Netherlands

Site Status

Haga Ziekenhuis locatie Leyweg-Oncology ( Site 1917)

The Hague, South Holland, Netherlands

Site Status

Universitair Medisch Centrum Utrecht ( Site 1910)

Utrecht, , Netherlands

Site Status

Uniwersytecki Szpital Kliniczny w Poznaniu ( Site 2401)

Poznan, Greater Poland Voivodeship, Poland

Site Status

Centrum Onkologii im. Prof. Franciszka Lukaszczyka ( Site 2402)

Bydgoszcz, Kuyavian-Pomeranian Voivodeship, Poland

Site Status

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie - O-Klinika Onkologii Klinicznej ( Site 240

Krakow, Lesser Poland Voivodeship, Poland

Site Status

Narodowy Instytut Onkologii im. Marii Sklodowskiej-Curie ( Site 2400)

Warsaw, Masovian Voivodeship, Poland

Site Status

Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2500)

Cluj-Napoca, Cluj, Romania

Site Status

Institutul Oncologic Prof.Dr. Ion Chiricuta Cluj-Napoca ( Site 2501)

Cluj-Napoca, Cluj, Romania

Site Status

Centrul de Oncologie "Sfântul Nectarie" ( Site 2502)

Craiova, Dolj, Romania

Site Status

Ivanovo Regional Oncology Dispensary ( Site 2616)

Ivanovo, Ivanovo Oblast, Russia

Site Status

FSBI United Hospital with Polyclinic ( Site 2613)

Moscow, Moscow, Russia

Site Status

SHI of Moscow City Oncology Clinical Hospital - 62 ( Site 2614)

Moscow, Moscow, Russia

Site Status

MEDSI Clinical Hospital on Pyatnitsky Highway-Departmentof Antitumor Drug therapy ( Site 2618)

Krasnogorsk, Moscow Oblast, Russia

Site Status

Hadassah Medical-Oncology department ( Site 2609)

Moscow, Moscow Oblast, Russia

Site Status

Volgograd Regional Uronephrological Center ( Site 2615)

Volzhsky, Volgograd Oblast, Russia

Site Status

Yaroslavl Regional Cancer Hospital-Oncology ( Site 2619)

Yaroslavl, Yaroslavl Oblast, Russia

Site Status

Chonnam National University Hwasun Hospital-Oncology ( Site 4203)

Hwasun, Jeonranamdo, South Korea

Site Status

Asan Medical Center ( Site 4200)

Seoul, , South Korea

Site Status

Samsung Medical Center ( Site 4201)

Seoul, , South Korea

Site Status

Complejo Hospitalario Universitario A Coruna ( Site 1502)

A Coruña, La Coruna, Spain

Site Status

Hospital Universitario 12 de Octubre-Medical Oncology ( Site 1508)

Madrid, Madrid, Comunidad de, Spain

Site Status

Hospital Universitari Vall d'Hebron-Departamento de Oncologia- VHIO ( Site 1507)

Barcelona, , Spain

Site Status

Hospital Clinic i Provincial ( Site 1500)

Barcelona, , Spain

Site Status

Hospital Santa Creu i Sant Pau ( Site 1501)

Barcelona, , Spain

Site Status

Hospital General Universitario Gregorio Maranon ( Site 1505)

Madrid, , Spain

Site Status

Hospital Clinico San Carlos ( Site 1504)

Madrid, , Spain

Site Status

Hospital Virgen del Rocio ( Site 1503)

Seville, , Spain

Site Status

Hopitaux Universitaires de Geneve HUG ( Site 1602)

Geneva, Canton of Geneva, Switzerland

Site Status

Universitaetsspital Zuerich ( Site 1601)

Zurich, Canton of Zurich, Switzerland

Site Status

Istituto Oncologica della Svizzera Italiana (IOSI) ( Site 1604)

Bellinzona, Canton Ticino, Switzerland

Site Status

Kantonsspital Graubuenden ( Site 1600)

Chur, Kanton Graubünden, Switzerland

Site Status

Aberdeen Royal Infirmary-Department of Oncology ( Site 3105)

Aberdeen, Aberdeen City, United Kingdom

Site Status

Royal United Hospital Bath England ( Site 3108)

Bath, Bath And North East Somerset, United Kingdom

Site Status

Nottingham University Hospitals NHS Trust. City Hospital Campus ( Site 3106)

Nottingham, England, United Kingdom

Site Status

Southend University Hospital ( Site 3112)

Southend, Essex, United Kingdom

Site Status

Imperial Healthcare NHS Trust Charing Cross Hospital ( Site 3107)

London, London, City of, United Kingdom

Site Status

Mount Vernon Cancer Centre ( Site 3101)

Northwood, London, City of, United Kingdom

Site Status

Musgrove Park Hospital ( Site 3103)

Taunton, Somerset, United Kingdom

Site Status

Singleton Hospital ( Site 3111)

Swansea, Wales, United Kingdom

Site Status

Countries

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United States Argentina Australia Austria Belgium Brazil Canada Chile Colombia Czechia Finland France Germany Greece Ireland Italy Japan Netherlands Poland Romania Russia South Korea Spain Switzerland United Kingdom

References

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Motzer RJ, Schmidinger M, Eto M, Suarez C, Figlin R, Liu Y, Perini R, Zhang Y, Heng DY. LITESPARK-011: belzutifan plus lenvatinib vs cabozantinib in advanced renal cell carcinoma after anti-PD-1/PD-L1 therapy. Future Oncol. 2023 Jan;19(2):113-121. doi: 10.2217/fon-2022-0802. Epub 2023 Feb 8.

Reference Type DERIVED
PMID: 36752726 (View on PubMed)

Related Links

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Other Identifiers

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MK-6482-011

Identifier Type: OTHER

Identifier Source: secondary_id

jRCT2031210311

Identifier Type: OTHER

Identifier Source: secondary_id

2024-510620-39

Identifier Type: REGISTRY

Identifier Source: secondary_id

U1111-1302-2815

Identifier Type: REGISTRY

Identifier Source: secondary_id

2020-002075-35

Identifier Type: EUDRACT_NUMBER

Identifier Source: secondary_id

6482-011

Identifier Type: -

Identifier Source: org_study_id

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