SpyGlass™ Discover Percutaneous

NCT ID: NCT04580940

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

50 participants

Study Classification

OBSERVATIONAL

Study Start Date

2021-07-27

Study Completion Date

2023-01-14

Brief Summary

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To document the clinical utility of percutaneous cholangiopancreatoscopy using a thin, disposable, flexible endoscope for evaluation and treatment of complex pancreaticobiliary disease in a prospective, multi-center case series

Detailed Description

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This case series aims to illustrate the clinical utility of percutaneous transhepatic cholangiopancreatoscopy using a thin, disposable, flexible endoscope performed by gastroenterological endoscopists and/or interventional radiologists in procedures including but not limited to:

* PTCS for tissue diagnosis in cases of surgically or pathologically-altered anatomy,
* PTCS for stone removal after surgically or pathologically-altered anatomy,
* Percutaneous rendezvous to aid ERCP after failed endoscopic cannulation,
* Percutaneous delivery of palliative intraluminal brachytherapy,
* Intra-procedural percutaneous salvage procedures when an initial route of access fails

Conditions

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Pancreatic Diseases Bile Duct Obstruction Bile Duct Diseases

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Subjects with complex pancreaticobiliary disease

All subjects will undergo the percutaneous transhepatic cholangiopancreatoscopy with the SpyGlass Discover System.

SpyGlass™ Discover Digital System

Intervention Type DEVICE

Observational, prospective, registry study for the clinical utility of the SpyGlass Discover digital catheter during a PTCS procedure.

Interventions

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SpyGlass™ Discover Digital System

Observational, prospective, registry study for the clinical utility of the SpyGlass Discover digital catheter during a PTCS procedure.

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

1. Scheduled for a percutaneous transhepatic procedure to access the pancreaticobiliary anatomy that will accommodate passage of SpyGlass™ Discover Digital Catheter per local standard of practice
2. Written informed consent from patient or legally authorized representative of the patient

Exclusion Criteria

1. Contraindication for cholangiopancreatoscopy
2. Subjects with unresolved adverse event(s) associated with prior percutaneous pancreaticobiliary ductal access
3. \<18 years of age
4. Potentially vulnerable subjects, including, but not limited to pregnant women
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Boston Scientific Corporation

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Ivo Boskoski, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Torsten Beyna, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Evangelisches Krakenhaus Düsseldorf

Mehran Fotoohi, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Virginia Mason

Arnaud Lemmers, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Erasme University Hospital

James Lau, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Prince of Wales Hospital

Eran Shlomovitz, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Toronto General Hospital, University Health Network

Mohan Ramchandani, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Asian Institute of Gastroenterology

Locations

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Virginia Mason Medical Center

Seattle, Washington, United States

Site Status

Erasme University Hospital

Brussels, , Belgium

Site Status

Toronto General Hospital, University Health Network

Toronto, Ontario, Canada

Site Status

Evangelisches Krakenhaus Düsseldorf

Düsseldorf, , Germany

Site Status

Prince of Wales Hospital

Shatin, NewTerritories, Hong Kong

Site Status

Asian Institute of Gastroenterology

Hyderabad, Somajiguda, India

Site Status

Fondazione Policlinico Universitario Agostino Gemelli IRCCS

Roma, , Italy

Site Status

Countries

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United States Belgium Canada Germany Hong Kong India Italy

References

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Boskoski I, Beyna T, Lau JY, Lemmers A, Fotoohi M, Ramchandani M, Pontecorvi V, Peetermans J, Shlomovitz E. Efficacy and safety of a single-use cholangioscope for percutaneous transhepatic cholangioscopy. Endosc Int Open. 2024 Aug 23;12(8):E981-E988. doi: 10.1055/a-2366-2265. eCollection 2024 Aug.

Reference Type DERIVED
PMID: 39184059 (View on PubMed)

Aihara H, Othman MO, Jawaid SA, Gorgun E, Sharma NR, Siddiqui UD, Peetermans JA, Rousseau MJ, Nishimura M. A multicenter, retrospective study of a through-the-needle injection-capable electrosurgical knife for endoscopic submucosal dissection. Gastrointest Endosc. 2024 Dec;100(6):1034-1042. doi: 10.1016/j.gie.2024.06.011. Epub 2024 Jun 13.

Reference Type DERIVED
PMID: 38879045 (View on PubMed)

Other Identifiers

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E7160

Identifier Type: -

Identifier Source: org_study_id