Theta Burst Stimulation Plus Habit Override Training for Compulsive Behaviors
NCT ID: NCT04580043
Last Updated: 2026-01-08
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
203 participants
INTERVENTIONAL
2020-12-28
2025-12-15
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
BASIC_SCIENCE
TRIPLE
Study Groups
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cTBS + Habit Override Training
Transcranial Magnetic Stimulation delivered in a continuous Theta Burst Stimulation (cTBS) pattern, paired with Habit Override Training.
Habit Override Practice
Computerized "brain training" to provide practice in overriding avoidance habits.
Transcranial Magnetic Stimulation
Non-invasive method for temporary, focal stimulation of brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
Sham TBS + Habit Override Training
Sham Transcranial Magnetic Stimulation, paired with Habit Override Training.
Habit Override Practice
Computerized "brain training" to provide practice in overriding avoidance habits.
Sham Transcranial Magnetic Stimulation
Sham stimulation of non-brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
cTBS + Sham Training
Transcranial Magnetic Stimulation delivered in a continuous Theta Burst Stimulation (cTBS) pattern, paired with Sham Training.
Transcranial Magnetic Stimulation
Non-invasive method for temporary, focal stimulation of brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
Sham Training
Computer-based task practice in a non-active/inert task.
Sham TBS + Sham Training
Sham Transcranial Magnetic Stimulation, paired with Sham Training.
Sham Training
Computer-based task practice in a non-active/inert task.
Sham Transcranial Magnetic Stimulation
Sham stimulation of non-brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
Interventions
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Habit Override Practice
Computerized "brain training" to provide practice in overriding avoidance habits.
Transcranial Magnetic Stimulation
Non-invasive method for temporary, focal stimulation of brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
Sham Training
Computer-based task practice in a non-active/inert task.
Sham Transcranial Magnetic Stimulation
Sham stimulation of non-brain areas. Delivered in a continuous Theta Burst Stimulation (TBS) pattern.
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
1. Be between the ages of 18 and 60 years
2. Endorse problematic compulsive behaviors, per self-report and clinician-administered measures.
3. Agree to video taping of structured clinical interview
4. Report that they will reside in the Pittsburgh area for at least 5 weeks
2. Medical contraindications for Transcranial Magnetic Stimulation (TMS):
1. Presence of a neurologic disorder or medication therapy known to alter seizure threshold (e.g., stroke, aneurysm, brain surgery, structural brain lesion, brain injury, frequent/severe headaches)
2. Recurrent seizures or epilepsy in participant or family history of hereditary epilepsy
3. Pregnancy
4. Metallic implants in body or other devices that may be affected by magnetic field
5. Significant heart disease or cerebrovascular disease
6. Medications with strong seizure threshold lowering potential or which may interfere with the efficacy of TMS (e.g., clozapine, stimulants)
3. Acute suicidality or other psychiatric crises requiring treatment escalation
4. Changes made to treatment regimen within 4 weeks of baseline assessment
5. Reading level \<6th grade as per participant self-report
6. Presence of bipolar, psychotic, autism spectrum, or substance use disorder (i.e. current problematic use of mood altering drugs such as cocaine, opiates, amphetamines, and barbiturates)
7. Presence of movement disorder or tics affecting manual responses
8. Inability to read text from 2 feet away (corrective lenses allowed)
18 Years
60 Years
ALL
No
Sponsors
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National Institute of Mental Health (NIMH)
NIH
Rebecca Price
OTHER
Responsible Party
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Rebecca Price
Associate Professor of Psychiatry
Principal Investigators
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Rebecca B Price, PhD
Role: PRINCIPAL_INVESTIGATOR
University of Pittsburgh
Locations
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Western Psychiatric Institute and Clinic
Pittsburgh, Pennsylvania, United States
Countries
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Other Identifiers
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STUDY19090219 (Part 2)
Identifier Type: -
Identifier Source: org_study_id
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