How is Social Connection Represented in the Brain?

NCT ID: NCT04577911

Last Updated: 2025-12-16

Basic Information

• Recruitment Status: RECRUITING
• Total Enrollment: 248 participants
• Study Classification: OBSERVATIONAL
• Study Start Date: 2021-04-01
• Study Completion Date: 2026-11-30

Brief Summary

Nearly half of the U.S. population sometimes or always experiences loneliness, which is alarming given that loneliness confers risk for negative mental and physical health outcomes. Extensive research suggests loneliness is characterized by subjective isolation: many lonely individuals maintain a number of relationships but still report feeling lonely. The goal of this proposal is to use functional magnetic resonance imaging to reveal how the brain represents our subjective connection to and isolation from other people, which will ultimately inform optimal ways to intervene to reduce loneliness.

Detailed Description

Extensive research suggests loneliness is characterized by subjective isolation: many lonely individuals maintain a number of relationships but still report feeling lonely. Thus, a neurobiological account of loneliness requires that we understand how the brain represents subjective connections to others and how loneliness alters these representations. The long-term goal of this proposal is to identify how subjective isolation is represented in the brain in order to identify novel ways to intervene on this representation to attenuate loneliness. This study proposes that the brain organizes representations of people based on subjective connection to them, and that loneliness systematically alters this organization. The Specific Aim 1 will determine whether subjective closeness organizes self and other representations in the brain. While undergoing fMRI, participants will complete tasks in which they reflect on themselves and other people. They will also report on their subjective closeness to the other people. The study will test whether the brain organizes mental representations of the self and one's own social network members based on subjective closeness. The Specific Aim 2 will determine how loneliness modulates self and other representations in the brain. The Specific, Exploratory Aim 3 will determine the cognitive consequences of altered self and other representation in loneliness. The proposal of this study is imperative for ultimately revealing neurocognitive mechanisms to intervene on to reduce loneliness.

Conditions

Loneliness

Study Design

• Observational Model Type: OTHER
• Study Time Perspective: CROSS_SECTIONAL

Interventions

Basic Science Experiment

participants complete cognitive tasks while undergoing functional magnetic resonance imaging (fMRI)

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• safe for MRI scanning
• not taking psychiatric medication

Exclusion Criteria

• not safe for MRI scanning
• taking psychiatric medication

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

National Institute of Mental Health (NIMH)

NIH

Sponsor Role: collaborator

Columbia University

OTHER

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Meghan Meyer, PhD

Role: PRINCIPAL_INVESTIGATOR

Columbia University

Locations

Columbia University Irving Medical Center

New York, New York, United States

Site Status: RECRUITING

Countries

United States

Central Contacts

Meghan L Meyer, PhD

Role: CONTACT

mlm2378@columbia.edu

650-521-1701

Facility Contacts

Meghan L Meyer, PhD

Role: primary

650-521-1701

Other Identifiers

1R01MH125406-01

Identifier Type: NIH

Identifier Source: secondary_id

View Link

AAAU7311

Identifier Type: -

Identifier Source: org_study_id