Trial Outcomes & Findings for Digital Interventions in Neuro-Rehabilitation: Gotcha! (NCT NCT04570215)
NCT ID: NCT04570215
Last Updated: 2026-01-22
Results Overview
The GOM is a free naming test using images of the participants' 6-10 personalized faces that they wanted to practice on. The test was completed in person at the main time points (T1-T4) and remotely during the weekly pre-therapy and therapy blocks. It was delivered via the app and consisted of the horizontally flipped versions of the photos that appeared as training items in order to reduce the effects of identity priming (Schacter, et al. 2004). The images were displayed for 6 seconds with a 2 second fade out. Responses were audio recorded and checked for accuracy with each attempt scoring either 1 or 0. As the number of items in the GOM varied across participants, these raw scores were converted into percentages ((correct responses/total number of stimuli)\*100). The Famous Faces were tested using the same parameters at T1-T4 using a PowerPoint presentation.
COMPLETED
NA
48 participants
T1 (baseline = initial assessment) to T4 (immediately following 6 weeks of Gotcha! therapy)
2026-01-22
Participant Flow
Recruitment was from nine NHS Patient Identification Centres across the UK (100 screened) and two main databases: Joint Dementia Research (JDR) database and Dementias Platform UK, Great Minds (DPUK) database (462 screened). Of the 562 assessed for eligibility, 514 were excluded. Of the remaining 98, 40 declined participation and 14 were excluded for other reasons leaving 48.
48 participants were recruited and entered the study, 10 dropped out (mostly due to COVID-19,), leaving 38 who completed the study. The background and results data pertain to these 38 participants.
Participant milestones
| Measure |
Gotcha! Therapy Application
Participants will receive the Gotcha therapy for six weeks as described in the Gotcha arm. After this time they enter a twelve week block of maintenance of therapy gains made in the initial six week therapy block.
The maintenance block consists of a weekly test of the Gotcha outcome measure to monitor the therapy gains made during the therapy block. If any previously correctly named person is incorrectly named during these weekly tests then the participant must complete a 'top-up' therapy session. They will then be tested again the following week.
The aim of this arm is to compare Gotcha maintenance with Gotcha, to see if extra testing and therapy is required to maintain gains made during an initial intense therapy block.
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|---|---|
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Overall Study
STARTED
|
38
|
|
Overall Study
COMPLETED
|
38
|
|
Overall Study
NOT COMPLETED
|
0
|
Reasons for withdrawal
Withdrawal data not reported
Baseline Characteristics
Race and Ethnicity were not collected from any participant.
Baseline characteristics by cohort
| Measure |
Gotcha! Therapy Application
n=38 Participants
Participants will receive the Gotcha therapy for six weeks as described in the Gotcha arm. After this time they enter a twelve week block of maintenance of therapy gains made in the initial six week therapy block.
The maintenance block consists of a weekly test of the Gotcha outcome measure to monitor the therapy gains made during the therapy block. If any previously correctly named person is incorrectly named during these weekly tests then the participant must complete a 'top-up' therapy session. They will then be tested again the following week.
The aim of this arm is to compare Gotcha maintenance with Gotcha, to see if extra testing and therapy is required to maintain gains made during an initial intense therapy block.
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|---|---|
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Age, Continuous
|
75.7 years
STANDARD_DEVIATION 10 • n=38 Participants
|
|
Sex: Female, Male
Female
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19 Participants
n=38 Participants
|
|
Sex: Female, Male
Male
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19 Participants
n=38 Participants
|
|
Gotch! Outcome Measure
Familiar Faces (trained items)
|
20 percent correct
STANDARD_DEVIATION 6 • n=38 Participants
|
|
Gotch! Outcome Measure
Famous Faces (untrained items)
|
19 percent correct
STANDARD_DEVIATION 6 • n=38 Participants
|
PRIMARY outcome
Timeframe: T1 (baseline = initial assessment) to T4 (immediately following 6 weeks of Gotcha! therapy)Population: The analysis is a 2\*2 ANOVA. TIME (which has two levels: T1 = baseline vs. T4 = immediately post-therapy), and ITEM (Familiar Faces = Trained vs. Famous Faces = Untrained). This controls for time effects and test-retest effects. The main hypothesis is that the interaction will be significant, driven by improved naming of Trained items at T4.
The GOM is a free naming test using images of the participants' 6-10 personalized faces that they wanted to practice on. The test was completed in person at the main time points (T1-T4) and remotely during the weekly pre-therapy and therapy blocks. It was delivered via the app and consisted of the horizontally flipped versions of the photos that appeared as training items in order to reduce the effects of identity priming (Schacter, et al. 2004). The images were displayed for 6 seconds with a 2 second fade out. Responses were audio recorded and checked for accuracy with each attempt scoring either 1 or 0. As the number of items in the GOM varied across participants, these raw scores were converted into percentages ((correct responses/total number of stimuli)\*100). The Famous Faces were tested using the same parameters at T1-T4 using a PowerPoint presentation.
Outcome measures
| Measure |
Familar Faces (Trained Items)
n=38 Participants
Each partcipant picked between 6-10 familiar people that they wanted to improve their free naming of. They provided the photos of these people and they were uploaded to the Gotcha! app by the research team.
|
Famous Faces (Unrained Items)
n=38 Participants
At baseline (T1) partcipants were tested with 50 famous faces. A subgroup of these were marches 1 to 1 with the trained items. Matched on accuracy and then similar characteristics (gender, age).
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|---|---|---|
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Gotcha! Outcome Measure
T1 (Baseline)
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20 percentage
Interval 14.0 to 26.0
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18 percentage
Interval 13.0 to 23.0
|
|
Gotcha! Outcome Measure
T4 (post-Gotcha! therapy)
|
59 percentage
Interval 49.0 to 69.0
|
17 percentage
Interval 13.0 to 23.0
|
Adverse Events
Gotcha! Therapy Application
Serious adverse events
Adverse event data not reported
Other adverse events
Adverse event data not reported
Additional Information
Prof Alexander Leff
UCL Queen Square Institute of Neurology
Results disclosure agreements
- Principal investigator is a sponsor employee
- Publication restrictions are in place