A Study of AK104 in Subjects With Locally Advanced Unresectable or Metastatic MSI-H/dMMR Solid Tumors

NCT ID: NCT04547101

Last Updated: 2022-10-19

Basic Information

• Recruitment Status: TERMINATED
• Clinical Phase: PHASE2
• Total Enrollment: 6 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2020-04-24
• Study Completion Date: 2022-09-30

Brief Summary

It is a single-arm, open-label, multicenter, phase II study to evaluate the safety, efficacy, pharmacokinetics (PK) and immunogenicity of AK104 as a single agent in subjects with previously-treated locally advanced unresectable or metastatic MSI-H or dMMR solid tumors.

Conditions

MSI-H/dMMR Solid Tumor

Study Design

• Allocation Method: NA
• Intervention Model: SINGLE_GROUP
• Primary Study Purpose: TREATMENT
• Blinding Strategy: NONE

Study Groups

AK104

Group Type: EXPERIMENTAL

AK104

Intervention Type: DRUG

AK104，6 mg/kg IV，every 2 weeks (Q2W)

Interventions

AK104

AK104，6 mg/kg IV，every 2 weeks (Q2W)

Intervention Type: DRUG

Eligibility Criteria

Inclusion Criteria

• Have signed written informed consent form voluntarily.
• Male or female, age ≥ 18 years on the day of signing informed consent form.
• ECOG of 0 or 1.
• Estimated life expectancy of ≥3 months.
• Histologically or cytologically documented locally advanced unresectable or metastatic solid tumors.
• Confirmed MSI-H/dMMR status by the central laboratory.
• Have experienced documented disease progression during or after at least first-line therapy.
• Have radiologically measurable disease based on RECIST 1.1.
• Adequate organ function.
• Have agreed to take effective contraception from the date of signing the informed consent form until 120 days after the last administration.

Exclusion Criteria

• Prior use of investigational products or devices within 4 weeks prior to C1D1 (Cycle 1 Day 1, the first dose of study drug).
• Presence of active autoimmune disease that have received systematic treatment in the past 2 years; or that is judged to be possibly relapsed or requires planned treatment by investigators.
• Active inflammatory bowel disease or that required treatment (e.g. Crohn's disease, ulcerative colitis or chronic diarrhea).
• Prior use of systematic corticosteroid (> 10 mg daily prednisone equivalents) or other immunosuppressive medications within 14 days prior to C1D1.
• Prior exposure to tumor immunotherapy, such as checkpoint inhibitors (eg. anti-PD-1, anti-PD-L1, anti-CTLA-4 antibody), checkpoint agonists or cellular therapy.
• Known history of allogeneic organ transplantation or allogeneic hematopoietic stem cell transplantation.
• Known presence or history of interstitial lung disease.
• History of gastrointestinal perforation and/or fistula within 6 months prior to C1D1.
• Serious infections within 4 weeks prior to C1D1.
• Known presence of active tuberculosis.
• Known untreated chronic hepatitis B or chronic hepatitis B virus DNA exceeding 1000 IU/ mL or active hepatitis C virus.
• Receipt of recent radiotherapy or anti-tumor treatment within 4 weeks prior to C1D1.
• Presence of meningeal metastasis, spinal cord compression, leptomeningeal disease or central nervous system metastasis, with some exceptions.
• Uncontrolled pleural effusion, pericardial effusion, or ascites requiring repeated drainage.
• Known history of sever hypersensitivity reaction to other monoclonal antibodies.
• Known history of allergy or hypersensitivity to AK104 or any of its components.
• Any conditions that, in the investigator's opinion, may put subjects treated with the study drug at risks, or interfere with the evaluation of study drug or subject safety, or the interpretation of results.

• Minimum Eligible Age: 18 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: No

Sponsors

Akeso Pharmaceuticals, Inc.

OTHER

Sponsor Role: collaborator

Akeso

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Principal Investigators

Ruihua Xu, MD

Role: PRINCIPAL_INVESTIGATOR

Sun Yat-sen University

Locations

Sun Yat-Sen University Cancer Center

Guangzhou, Guangdong, China

Countries

China

Other Identifiers

AK104-205

Identifier Type: -

Identifier Source: org_study_id