A Study of Topical Arnica & Ledum on Bruise Reduction in HNV

NCT ID: NCT04533269

Last Updated: 2021-01-08

Basic Information

• Recruitment Status: UNKNOWN
• Clinical Phase: NA
• Total Enrollment: 150 participants
• Study Classification: INTERVENTIONAL
• Study Start Date: 2021-07-31
• Study Completion Date: 2022-11-30

Brief Summary

Subjects will have a bruise induced. A pad containing either a placebo or active will be applied to the bruise. Photographs will be taken over the following days to record bruise healing.

Detailed Description

This is a randomized, double-blind, placebo-controlled, crossover, multicenter study that will be used to evaluate the difference in bruise reduction efficacy between active remedy and placebo when a mechanical bruise is induced. The trial will be conducted at 5-8 sites with up to 150 subjects. Each subject will be injured two times using the same bruise-inducing mechanism, and the resulting bruises will be treated with active remedy or placebo-infused pads that will be identical in appearance. Subjects and study investigators will be blinded to the order of treatment assignment. Subjects will be asked to come to the clinic for photographic assessments of the bruise. Each subject will be randomly assigned to have a placebo or active remedy pad applied over each mechanically induced bruise on Day 1. The pad will be applied by study staff immediately after bruise induction (within 5 minutes). The pad will cover the bruised area completely, and then sealed with Tegaderm. All procedures, including bruise induction, treatment, and photography, will be administered by study staff who are blinded to treatment type. All photographs will be rated according to standardized criteria by blinded, trained study investigators after the completion of all subject data collection.

Conditions

Bruise, Contusion

Study Design

• Allocation Method: RANDOMIZED
• Intervention Model: CROSSOVER
• Primary Study Purpose: TREATMENT
• Blinding Strategy: QUADRUPLE

Study Groups

Active

Arnica montana and Ledum palustre infused Pad

Group Type: EXPERIMENTAL

Arnica montana, Ledum palustre

Intervention Type: OTHER

Homeopathic

Placebo

Pad (Matching appearance with Active)

Group Type: PLACEBO_COMPARATOR

Arnica montana, Ledum palustre

Intervention Type: OTHER

Homeopathic

Interventions

Arnica montana, Ledum palustre

Homeopathic

Intervention Type: OTHER

Eligibility Criteria

Inclusion Criteria

• Fitzpatrick skin type 1-3
• BMI 25 kg/m2
• Self described bruisers
• Intact skin in the target area, free of markings, blemishes and hair

Exclusion Criteria

• Use of recreational drugs, steroids, pain medications, other homeopathic remedies, anticoagulant therapies, antiplatelet therapy
• Known history of dermal sensitivity, serious illness, hematological abnormality, impaired wound healing
• Inability to forego application of topical products in the target area
• Hair removal by laser, wax or chemicals within one week prior to Day 1
• Avoid tanning beds
• History of allergy to topical gels, Arnica or Ledum
• Active wound or infection in the target area
• History of keloids or hypertrophic scarring
• History of collagen or vascular disease
• History of organ transplant

• Minimum Eligible Age: 18 Years
• Maximum Eligible Age: 65 Years
• Eligible Sex: ALL
• Accepts Healthy Volunteers: Yes

Sponsors

Cearna, Inc.

INDUSTRY

Sponsor Role: lead

Responsible Party

Responsibility Role: SPONSOR

Central Contacts

Jacqueline Blem

Role: CONTACT

jacqui@cardiffclinical.com

858-945-6456

Other Identifiers

CI-B001

Identifier Type: -

Identifier Source: org_study_id