Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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RECRUITING
NA
100 participants
INTERVENTIONAL
2020-05-14
2024-03-30
Brief Summary
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Detailed Description
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\_ In control group, patients will be treated with antagonist protocol: The cycle of ovarian stimulation is started on the second day or third day of period. hCG will be used to trigger when at least two follicles ≥ 17 mm. Approximately 36 hours later, oocytes will be retrieved vaginally under ultrasound monitoring and ICSI will be performed. If serum progesterone on the day of trigger ≥ 1.5 ng/ml, all embryos will be cryostored; otherwise, fresh embryos will be transferred.
Conditions
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Keywords
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Study Design
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NON_RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Study
the patients in this group will be treated with double stimulation
double stimulation
the patients will be treated with two consecutive ovarian stimulations in one cycle
Control
the patients in this group will be treated with conventional ovarian stimulation
conventional ovarian stimulation
the patients will be treated with one conventional ovarian stimulation in one cycle
Interventions
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double stimulation
the patients will be treated with two consecutive ovarian stimulations in one cycle
conventional ovarian stimulation
the patients will be treated with one conventional ovarian stimulation in one cycle
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* AMH ≥ 0.3 ng/ml and ≤ 1.2 ng/ml.
* OR 3 ≤ AFC ≤7.
* Normal shape of uterus (based on ultrasound).
* Body mass index within 28 - 37 kg/m2
Exclusion Criteria
* Endometriosis.
* Leiomyomas distorting the endometrium
* Sperm extracted from surgical procedures (i.e. PESA, TESE).
* Patients refuse to continue participating in the study.
* Patients injected with wrong dose of gonadotropins during the treatment.
* Serious complications or accidents arise forcing the patients to discontinue the treatments.
* Ovarian surgery
* Previous chemotherapy or pelvic irradiation
18 Years
40 Years
FEMALE
Yes
Sponsors
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Federico II University
OTHER
University of Medicine and Pharmacy at Ho Chi Minh City
OTHER
Tu Du Hospital
OTHER_GOV
Responsible Party
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Le Thi Minh Chau
Head of department of Infertility
Principal Investigators
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Chau TM Le, PhD
Role: STUDY_DIRECTOR
Tu Du Hospital
Locations
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Department of Infertility of Tu Du hospital
Ho Chi Minh City, , Vietnam
Countries
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Central Contacts
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Facility Contacts
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Chau TM Le, PhD
Role: primary
Anh Q Nguyen, MMSc
Role: backup
References
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Cardoso MCA, Evangelista A, Sartorio C, Vaz G, Werneck CLV, Guimaraes FM, Sa PG, Erthal MC. Can ovarian double-stimulation in the same menstrual cycle improve IVF outcomes? JBRA Assist Reprod. 2017 Sep 1;21(3):217-221. doi: 10.5935/1518-0557.20170042.
Kuang Y, Chen Q, Hong Q, Lyu Q, Ai A, Fu Y, Shoham Z. Double stimulations during the follicular and luteal phases of poor responders in IVF/ICSI programmes (Shanghai protocol). Reprod Biomed Online. 2014 Dec;29(6):684-91. doi: 10.1016/j.rbmo.2014.08.009. Epub 2014 Sep 6.
Poseidon Group (Patient-Oriented Strategies Encompassing IndividualizeD Oocyte Number); Alviggi C, Andersen CY, Buehler K, Conforti A, De Placido G, Esteves SC, Fischer R, Galliano D, Polyzos NP, Sunkara SK, Ubaldi FM, Humaidan P. A new more detailed stratification of low responders to ovarian stimulation: from a poor ovarian response to a low prognosis concept. Fertil Steril. 2016 Jun;105(6):1452-3. doi: 10.1016/j.fertnstert.2016.02.005. Epub 2016 Feb 26. No abstract available.
Ubaldi FM, Capalbo A, Vaiarelli A, Cimadomo D, Colamaria S, Alviggi C, Trabucco E, Venturella R, Vajta G, Rienzi L. Follicular versus luteal phase ovarian stimulation during the same menstrual cycle (DuoStim) in a reduced ovarian reserve population results in a similar euploid blastocyst formation rate: new insight in ovarian reserve exploitation. Fertil Steril. 2016 Jun;105(6):1488-1495.e1. doi: 10.1016/j.fertnstert.2016.03.002. Epub 2016 Mar 25.
Other Identifiers
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CS/TD/20/05
Identifier Type: -
Identifier Source: org_study_id