Case Fatalities in Hospitalised COVID-19 Patients in the UK

NCT ID: NCT04527458

Last Updated: 2020-08-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

70000 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-02-24

Study Completion Date

2020-08-02

Brief Summary

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This study will investigate how the case fatality in hospitalised patients with COVID-19 has changed throughout the pandemic. It will also explore possible mechanisms that could be driving these changes. This analysis will enhance our understanding of the virus, which will be important for researchers and clinicians to respond appropriately.

Detailed Description

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Conditions

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Covid19

Study Design

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Observational Model Type

COHORT

Study Time Perspective

PROSPECTIVE

Study Groups

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Hospitalisations

All hospitalised COVID patients

Patient Characteristics

Intervention Type OTHER

Characteristics of the patients

COVID-19 treatments

Intervention Type OTHER

Specific treatments used on COVID-19 patients

Differences in triage

Intervention Type OTHER

Triage criteria for treating COVID-19 patients

Surge capacity

Intervention Type OTHER

Capacity of hospitals

Critical care

All hospitalised COVID patients in critical care

Patient Characteristics

Intervention Type OTHER

Characteristics of the patients

COVID-19 treatments

Intervention Type OTHER

Specific treatments used on COVID-19 patients

Differences in triage

Intervention Type OTHER

Triage criteria for treating COVID-19 patients

Surge capacity

Intervention Type OTHER

Capacity of hospitals

Interventions

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Patient Characteristics

Characteristics of the patients

Intervention Type OTHER

COVID-19 treatments

Specific treatments used on COVID-19 patients

Intervention Type OTHER

Differences in triage

Triage criteria for treating COVID-19 patients

Intervention Type OTHER

Surge capacity

Capacity of hospitals

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All patients admitted with a proven or high likelihood of COVID-19
Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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International Severe Acute Respiratory and Emerging Infection Consortium

OTHER

Sponsor Role collaborator

BREATHE Health Data Research Hub

UNKNOWN

Sponsor Role collaborator

University of Edinburgh

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Annemarie B Docherty

Role: PRINCIPAL_INVESTIGATOR

Usher Institute, University of Edinburgh

Ewen M Harrison

Role: PRINCIPAL_INVESTIGATOR

Usher Institute, University of Edinburgh

Rachel H Mulholland

Role: PRINCIPAL_INVESTIGATOR

Usher Institute, University of Edinburgh

Locations

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University of Edinburgh

Edinburgh, , United Kingdom

Site Status

Countries

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United Kingdom

References

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Docherty AB, Harrison EM, Green CA, Hardwick HE, Pius R, Norman L, Holden KA, Read JM, Dondelinger F, Carson G, Merson L, Lee J, Plotkin D, Sigfrid L, Halpin S, Jackson C, Gamble C, Horby PW, Nguyen-Van-Tam JS, Ho A, Russell CD, Dunning J, Openshaw PJ, Baillie JK, Semple MG; ISARIC4C investigators. Features of 20 133 UK patients in hospital with covid-19 using the ISARIC WHO Clinical Characterisation Protocol: prospective observational cohort study. BMJ. 2020 May 22;369:m1985. doi: 10.1136/bmj.m1985.

Reference Type BACKGROUND
PMID: 32444460 (View on PubMed)

Related Links

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https://isaric4c.net/

ISARIC 4C website

Other Identifiers

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ISARIC_COVID_CF

Identifier Type: -

Identifier Source: org_study_id

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