A Study of Sodium Oligomannate (GV-971) in Participants With Mild to Moderate Alzheimer's Disease

NCT ID: NCT04520412

Last Updated: 2022-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

SUSPENDED

Clinical Phase

PHASE3

Total Enrollment

2046 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-27

Study Completion Date

2026-10-31

Brief Summary

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The purpose of this study is to evaluate the safety, tolerability and efficacy of GV-971 in mild to moderate Alzheimer's disease.

Detailed Description

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Conditions

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Alzheimer Disease

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

QUADRUPLE

Participants Caregivers Investigators Outcome Assessors

Study Groups

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GV-971

Group Type EXPERIMENTAL

GV-971

Intervention Type DRUG

Administered PO

Placebo

Group Type PLACEBO_COMPARATOR

Placebo

Intervention Type DRUG

Administered PO

Interventions

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GV-971

Administered PO

Intervention Type DRUG

Placebo

Administered PO

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Mild to moderate AD per NIA-AA.
* History of cognitive and functional decline over at least 1 year.
* MMSE scores between 11 and 24 (inclusive) at baseline.
* Brain MRI scan show the highest possibility of AD.
* Have a study partner/caregiver.

Exclusion Criteria

* Diagnosis of a dementia-related central nervous system disease other than AD.
* Major structural brain disease as judged by MRI.
* A resting heart rate of \< 50 beats per minute (bpm) after 5 minutes of rest in sitting or supine position.
* Major medical illness or unstable medical condition within 6 months of screening.
* Concomitant use of AChEIs and/or memantine within 30 days before first MMSE score, and during the study.
* Inadequate hepatic function.
* Inadequate organ and marrow function.
* ECG clinically significant abnormalities.
Minimum Eligible Age

50 Years

Maximum Eligible Age

85 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Green Valley (Shanghai) Pharmaceuticals Co., Ltd.

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Study Director, Ph D

Role: STUDY_DIRECTOR

Green Valley (Shanghai) Pharmaceuticals Co., Ltd.

Locations

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Cognitive Clinical Trials, LLC

Gilbert, Arizona, United States

Site Status

Banner Alzheimer's Institute

Phoenix, Arizona, United States

Site Status

St. Joseph's Hospital and Medical Center

Phoenix, Arizona, United States

Site Status

Banner Sun Health Research Institute

Sun City, Arizona, United States

Site Status

Banner Alzheimer's Institute

Tucson, Arizona, United States

Site Status

Irvine Clinical Research

Irvine, California, United States

Site Status

Sunwise Clinical Research

Lafayette, California, United States

Site Status

Pharmacology Research Institute

Los Alamitos, California, United States

Site Status

Pacific Research Network, Inc

San Diego, California, United States

Site Status

Pacific Research Network

San Diego, California, United States

Site Status

Syrentis Clinical Research

Santa Ana, California, United States

Site Status

Schuster Med Research Institute

Sherman Oaks, California, United States

Site Status

JEM Research LLC

Atlantis, Florida, United States

Site Status

Brain Matters Research

Delray Beach, Florida, United States

Site Status

Finlay Medical Research Corp

Greenacres City, Florida, United States

Site Status

Velocity Clinical Research

Hallandale, Florida, United States

Site Status

Jacksonville Center for Clinical Research

Jacksonville, Florida, United States

Site Status

Charter Research, LLC

Lady Lake, Florida, United States

Site Status

Innovative Clinical Research, Inc.

Lauderhill, Florida, United States

Site Status

ClinCloud, LLC

Maitland, Florida, United States

Site Status

Merritt Island Medical Research, LLC

Merritt Island, Florida, United States

Site Status

Collier Neurologic Specialists

Naples, Florida, United States

Site Status

Suncoast Clinical Research Inc.

New Port Richey, Florida, United States

Site Status

Clinical Neuroscience Solutions, Inc.

Orlando, Florida, United States

Site Status

Synexus Clinical Research

Orlando, Florida, United States

Site Status

Neurology Associates of Ormond Beach

Ormond Beach, Florida, United States

Site Status

Quantum Lab CNS Clinical Research

Pompano Beach, Florida, United States

Site Status

Progressive Medical Research

Port Orange, Florida, United States

Site Status

Intercoastal Medical Group

Sarasota, Florida, United States

Site Status

Stedman Clinical Trials, LLC

Tampa, Florida, United States

Site Status

Meridien Research

Tampa, Florida, United States

Site Status

Synexus The Villages

The Villages, Florida, United States

Site Status

NeuroStudies.net, LLC

Decatur, Georgia, United States

Site Status

Great Lakes Clinical Trials

Chicago, Illinois, United States

Site Status

Indiana University

Indianapolis, Indiana, United States

Site Status

Alliance Multispecialty Research

Wichita, Kansas, United States

Site Status

Activmed Practices&Research

Lawrence, Massachusetts, United States

Site Status

Quest Research Institute

Farmington Hills, Michigan, United States

Site Status

Barnes-Jewish Hospital IDS

St Louis, Missouri, United States

Site Status

University of Nebraska Medical Center-Hematology/Oncology Section

Omaha, Nebraska, United States

Site Status

Cognitive Clinical Trials, LLC

Omaha, Nebraska, United States

Site Status

Altea Research Institute, Las Vegas

Las Vegas, Nevada, United States

Site Status

Global Medical Institutes, LLC

Princeton, New Jersey, United States

Site Status

The Cognitive Research Center of New Jersey

Springfield, New Jersey, United States

Site Status

Advanced Memory Research Institute of NJ, PC

Toms River, New Jersey, United States

Site Status

Integrative Clinical Trials LLC

Brooklyn, New York, United States

Site Status

UBMD Neurology

Buffalo, New York, United States

Site Status

Clarity Clinical Research

East Syracuse, New York, United States

Site Status

Richmond Behavioral Associates

Staten Island, New York, United States

Site Status

Behavioral Health Research Center

Charlotte, North Carolina, United States

Site Status

AMC Research, LLC

Charlotte, North Carolina, United States

Site Status

Guilford Neurologic Associate

Greensboro, North Carolina, United States

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Insight Clinical Trials LLC

Beachwood, Ohio, United States

Site Status

New Horizons Clinical Research

Cincinnati, Ohio, United States

Site Status

Cleveland Clinic Foundation

Cleveland, Ohio, United States

Site Status

Columbus Neuroscience, LLC

Westerville, Ohio, United States

Site Status

Summit Research Network(Oregon)Inc.

Portland, Oregon, United States

Site Status

Oregon Health&Science Universty

Portland, Oregon, United States

Site Status

Oregon Neurology Associates

Springfield, Oregon, United States

Site Status

Abington Neurological Associates, LTD

Abington, Pennsylvania, United States

Site Status

SCarolina Institute Brain Health

Charleston, South Carolina, United States

Site Status

Kerwin Research Center

Dallas, Texas, United States

Site Status

Huston Methodist Hospital

Houston, Texas, United States

Site Status

Clinical Trials of Texas; Inc

San Antonio, Texas, United States

Site Status

Advanced Clinical Research

West Jordan, Utah, United States

Site Status

Cognition Health

Fairfax, Virginia, United States

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University Washington MedCentre

Seattle, Washington, United States

Site Status

Hornsby Ku-ring-gai Hospital

Hornsby, New South Wales, Australia

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KaRa MINDS

Macquarie Park, New South Wales, Australia

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Austin Health - Heidelberg Repatriation Hospital

Melbourne, Victoria, Australia

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Alzheimer's Research Foundation

Nedlands, Western Australia, Australia

Site Status

Heritage Medical Research Clinic

Calgary, Alberta, Canada

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The Medical Arts Health Research Group

Kamloops, British Columbia, Canada

Site Status

Okanagan Clinical Trials

Kelowna, British Columbia, Canada

Site Status

MedicalArtsHealth Research Grp

Kelowna, British Columbia, Canada

Site Status

MedicalArtsHealth Research Grp

Penticton, British Columbia, Canada

Site Status

Vancouver Island Health Authority

Victoria, British Columbia, Canada

Site Status

Medical Arts Health Research Grp

West Vancouver, British Columbia, Canada

Site Status

True North Clinical Research Inc

Halifax, Nova Scotia, Canada

Site Status

True North Clinical Research

New Minas, Nova Scotia, Canada

Site Status

Recherches Neuro-Hippocampe Inc., d/b/a Ottawa Memory Clinic

Ottawa, Ontario, Canada

Site Status

Toronto Memory Program

Toronto, Ontario, Canada

Site Status

Toronto Western Hospital

Toronto, Ontario, Canada

Site Status

Clinique Memoire Outaouais

Gatineau, Quebec, Canada

Site Status

Q & T Research Sherbrooke Inc

Sherbrooke, Quebec, Canada

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Diex Recherche Sherbrooke

Sherbrooke, Quebec, Canada

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Douglas Hospital Research Centre

Verdun, Quebec, Canada

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ALPHA Recherche Clinique

Québec, , Canada

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1st Hospital of Anhui MU

Hefei, Anhui, China

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Peking Union Hospital

Beijing, Beijing Municipality, China

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Peking University 1st Hospital

Beijing, Beijing Municipality, China

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Xuanwu Hospital

Beijing, Beijing Municipality, China

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Beijing Tiantan Hospital

Beijing, Beijing Municipality, China

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Beijing Anding Hospital

Beijing, Beijing Municipality, China

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Beijing Hospital

Beijing, Beijing Municipality, China

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Beijing Tong Ren Hospital

Beijing, Beijing Municipality, China

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1st Hospital of Chongqing MU

Chongqing, Chongqing Municipality, China

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Fujian Union Hospital

Fuzhou, Fujian, China

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1st Hospital of Fujian MU

Fuzhou, Fujian, China

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Zhongshan Hospital Xiamen U

Xiamen, Fujian, China

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1st Hospital of Guangzhou MU

Guangzhou, Guangdong, China

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Guangzhou 1st People's Hospital

Guangzhou, Guangdong, China

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2nd Hospital of Guangzhou MU

Guangzhou, Guangdong, China

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2nd Hospital Zhongshan University

Guangzhou, Guangdong, China

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Kangning Hospital of Shenzhen

Shenzhen, Guangdong, China

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1st Hospital of Hebei MU

Shijiazhuang, Hebei, China

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Tangshan Gongren Hospital

Tangshan, Hebei, China

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Xiangya Hospital

Changsha, Hunan, China

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Yueyang 1st People's Hospital

Yueyang, Hunan, China

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Nanjing Drum Tower Hospital

Nanjing, Jiangsu, China

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Zhong Da Hospital

Nanjing, Jiangsu, China

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2nd Hospital Soochow University

Suzhou, Jiangsu, China

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Jiangxi Provincial Hospital

Nanchang, Jiangxi, China

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1st Hospital Jilin University

Changchun, Jilin, China

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General Hospital of Ningxia MU

Yinchuan, Ningxia, China

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Tang Du Hospital

Xi'an, Shaanxi, China

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Xi'an Mental Health Cente

Xi'an, Shaanxi, China

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Qilu Hospital

Jinan, Shandong, China

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Shandong Provincial Hospital

Jinan, Shandong, China

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Qingdao Municipal Hospital

Qingdao, Shandong, China

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Ruijin Hospital

Shanghai, Shanghai Municipality, China

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Shanghai Mental Health Center

Shanghai, Shanghai Municipality, China

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Huashan Hospital; Fudan U

Shanghai, Shanghai Municipality, China

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Shanghai General Hospital

Shanghai, Shanghai Municipality, China

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1st Hospital of Shanxi MU

Taiyuan, Shanxi, China

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West China Hospital

Chengdu, Sichuan, China

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Tianjin MU General Hospital

Tianjin, Tianjin Municipality, China

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Tianjin Huanhu Hospital

Tianjin, Tianjin Municipality, China

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1st Hospital of Kunming MU

Kunming, Yunnan, China

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Zhejiang Provincial Hospital

Hangzhou, Zhejiang, China

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1st Hospital Zhejiang University

Hangzhou, Zhejiang, China

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1st Hospital of Wenzhou MU

Wenzhou, Zhejiang, China

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NeuropsychiatrieHK s.r.o.

Hradec Králové, , Czechia

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BRAIN-SOULTHERAPY s.r.o.

Kladno, , Czechia

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Neuroterapie KH s.r.o.

Kutná Hora, , Czechia

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Clintrial s.r.o.

Prague, , Czechia

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FORBELI s.r.o.

Prague, , Czechia

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Neuropsychiatrie s.r.o.

Prague, , Czechia

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Centred Investigation Clinique

Strasbourg, Bas Rhin, France

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CHUTimone Adultes Service

Marseille, Bouches-du-Rhône, France

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HOPITAL Gui de CHAULIAC

Montpellier, Cedex 5, France

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Centre Memoire Ressources

Dijon, De Lattre de Tassigny, France

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Groupe Hospitalier Pellegrin

Bordeaux, Gironde, France

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Hopitaux Civils de Colmar

Colmar, Grand Est, France

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Recherche Clinique Gerontopole

Toulouse, Haute Garonne, France

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Pharmacie CHU de Rennes

Rennes, Ille Et Vilaine, France

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CHU Tours-Hopital Bretonneau

Tonnerre, Indre Et Loire, France

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CHU Nantes-Hopital Nord Laennec

Nantes, Loire Atlantique, France

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CHU Reims-Hopital Maison Blanche

Reims, Marne, France

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Neurologique Pierre Wertheimer

Bron, Rhone, France

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Hopital des Charpennes

Villeurbanne, Rhone, France

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CMRR Paris Nord

Paris, , France

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Prince of Wales Hospital

Shatin, , Hong Kong

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VUmc Goederenontvangst

Amsterdam, Van Der Boechorststraat 6, Netherlands

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Pharmacy Jeroen Bosch Ziekenhuis

's-Hertogenbosch, , Netherlands

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Amphia Hospital Breda

Breda, , Netherlands

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Klinische Farmacie

Zwolle, , Netherlands

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Podlaskie Centrum Psychogeriatri

Bialystok, , Poland

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NZOZ Vitamed

Bydgoszcz, , Poland

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Wielospec. Poradnia Lekarska

Katowice, , Poland

Site Status

Nzoz Novo Med

Katowice, , Poland

Site Status

Specjalistyczne Gabinety Sp.zo.o

Krakow, , Poland

Site Status

NZOZ Neuromed MiMNastajSpp

Lublin, , Poland

Site Status

Medicome Sp z o o

Oświęcim, , Poland

Site Status

Solumed Centrum Medyczne

Poznan, , Poland

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Neuro Protect

Warsaw, , Poland

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Wrclawskie Cntrm Alzheimerowskie

Wroclaw, , Poland

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Wielospecjalistyczne Centrm Med

Zabrze, , Poland

Site Status

National Taiwan UniversityHosp

Taipei, , Taiwan

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Tri Service General Hospital

Taipei, , Taiwan

Site Status

Chang GungMemorial Hosp Linkou

Taoyuan District, , Taiwan

Site Status

Countries

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United States Australia Canada China Czechia France Hong Kong Netherlands Poland Taiwan

Other Identifiers

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GV971-007

Identifier Type: -

Identifier Source: org_study_id

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