Psychological Interventions to Prevent Late Effects in Breast Cancer

NCT ID: NCT04518085

Last Updated: 2023-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

203 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-10-01

Study Completion Date

2023-11-01

Brief Summary

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The study aims to investigate whether a combined pre-operative medical hypnosis plus a post-operative internet-based acceptance and commitment intervention are more effective in preventing post-surgical pain and fatigue following breast cancer surgery compared with pre-operative mindfulness plus treatment as usual.

Detailed Description

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The trial will include 200 patients undergoing breast cancer surgery at Oslo University Hospital. The patients will be randomized into two groups. One group will receive a 20 minute pre-surgical hypnosis session delivered by an experienced clinical psychologist plus a post-surgical internet-based acceptance and commitment intervention. The control group will receive a 20 minute pre-surgical mindfulness session delivered through an audio recording plus treatment as usual. The primary outcomes of the study are quantitative measures of post-surgical pain and fatigue. In addition, relationships between biomarkers of stress and subacute post-surgical pain and fatigue will be analyzed using using blood- and hair samples. The study uses a longitudinal design with baseline measures obtained pre-surgery and follow up measures obtained 3 and 12 months post-surgery.

Conditions

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Pain, Postoperative Fatigue Breast Cancer

Keywords

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Breast cancer Post-surgical pain Fatigue Hypnosis Acceptance and commitment therapy

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Randomized Controlled Trial, in which participants are randomly allocated to either the intervention group or an active control group.
Primary Study Purpose

PREVENTION

Blinding Strategy

DOUBLE

Investigators Outcome Assessors
The intervention group vs. active control group status will be known to the participants and the health care personnel delivering the interventions. However, the investigator, outcome assessor and the additional health care personnel at the unit will be masked to the conditions.

Study Groups

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Hypnosis + iACT

Single 20 minute medical hypnosis session delivered pre-surgery plus internet-based acceptance and commitment therapy delivered post-surgery

Group Type EXPERIMENTAL

Medical hypnosis

Intervention Type BEHAVIORAL

Single session 20 minutes hypnosis session originally developed and tested by Montgomery et al. (2007) in a similar setting. Delivered by an experienced clinical psychologist.

Internet-based Acceptance and Commitment Therapy (iACT)

Intervention Type BEHAVIORAL

Access to an online platform developed to this study containing video clips and audio files with ACT consistent material

Mindfulness + treatment as usual (TAU)

Single 20 minute mindfulness session delivered pre-surgery plus treatment as usual post-surgery

Group Type ACTIVE_COMPARATOR

Mindfulness session

Intervention Type BEHAVIORAL

Single session mindfulness session delivered by audio file

Treatment as Usual (TAU)

Intervention Type BEHAVIORAL

Treatment as usual as part of post-surical care

Interventions

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Medical hypnosis

Single session 20 minutes hypnosis session originally developed and tested by Montgomery et al. (2007) in a similar setting. Delivered by an experienced clinical psychologist.

Intervention Type BEHAVIORAL

Internet-based Acceptance and Commitment Therapy (iACT)

Access to an online platform developed to this study containing video clips and audio files with ACT consistent material

Intervention Type BEHAVIORAL

Mindfulness session

Single session mindfulness session delivered by audio file

Intervention Type BEHAVIORAL

Treatment as Usual (TAU)

Treatment as usual as part of post-surical care

Intervention Type BEHAVIORAL

Eligibility Criteria

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Inclusion Criteria

* Women diagnosed with breast cancer and scheduled for surgery
* Be able to provide informed consent

Exclusion Criteria

* Insufficient Norwegian speaking or writing skills to participate in the interventions and fill out questionnaires
* Cognitive and psychiatric impairment
* Other serious malignancies
Minimum Eligible Age

18 Years

Maximum Eligible Age

70 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Oslo University Hospital

OTHER

Sponsor Role collaborator

University of Oslo

OTHER

Sponsor Role lead

Responsible Party

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Silje Endresen Reme

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Silje E Reme, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Oslo + Oslo University Hospital

Henrik B Jacobsen, PhD

Role: PRINCIPAL_INVESTIGATOR

University of Oslo + Oslo University Hospital

Locations

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Oslo University Hospital (Aker Hospital)

Oslo, , Norway

Site Status

Countries

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Norway

References

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Lind SB, Jacobsen HB, Solbakken OA, Reme SE. Clinical Hypnosis in Medical Care: A Mixed-Method Feasibility Study. Integr Cancer Ther. 2021 Jan-Dec;20:15347354211058678. doi: 10.1177/15347354211058678.

Reference Type BACKGROUND
PMID: 34818921 (View on PubMed)

Engel S, Jacobsen HB, Reme SE. A cross-sectional study of fear of surgery in female breast cancer patients: Prevalence, severity, and sources, as well as relevant differences among patients experiencing high, moderate, and low fear of surgery. PLoS One. 2023 Jun 23;18(6):e0287641. doi: 10.1371/journal.pone.0287641. eCollection 2023.

Reference Type BACKGROUND
PMID: 37352256 (View on PubMed)

Munk A, Jacobsen HB, Schnur J, Montgomery G, Reme SE. Acute and subacute postsurgical pain in women with breast cancer: incidence and associations with biopsychosocial predictors-a secondary analysis of a randomized controlled trial. Pain Rep. 2023 Jan 10;8(1):e1058. doi: 10.1097/PR9.0000000000001058. eCollection 2023 Jan.

Reference Type BACKGROUND
PMID: 36699993 (View on PubMed)

Reme SE, Munk A, Holter MTS, Falk RS, Jacobsen HB. Pre- and post-operative psychological interventions to prevent pain and fatigue after breast cancer surgery (PREVENT): Protocol for a randomized controlled trial. PLoS One. 2022 Jul 8;17(7):e0268606. doi: 10.1371/journal.pone.0268606. eCollection 2022.

Reference Type BACKGROUND
PMID: 35802618 (View on PubMed)

Related Links

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Other Identifiers

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201906

Identifier Type: -

Identifier Source: org_study_id