Ultra Long-Term Sleep Monitoring Using UNEEG™ Medical 24/7 EEG™ SubQ

NCT ID: NCT04513743

Last Updated: 2023-12-08

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

25 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-09-07

Study Completion Date

2022-07-04

Brief Summary

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This study aims to evaluate the agreement between automated sleep analysis by UNEEG medical's 24/7 EEG™ SubQ device using a deep learning algorithm and the consensus score of multiple sleep technologists' manual scoring of 120 gold-standard polysomnograms (PSG) from healthy subjects.

Detailed Description

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The aim of the study is to evaluate the agreement between automated sleep analysis by UNEEG medical's 24/7 EEG™ SubQ device using a deep learning algorithm and the consensus score of multiple sleep technologists' manual scoring of 120 gold-standard polysomnograms (PSG).

The study will enroll 20 healthy subjects who will wear the UNEEG™ SubQ device for 365 consecutive nights. All subjects are prescreened and invited to an interview to confirm eligibility. Subjects who provide informed consent are enrolled and will complete a detailed demographic, medical, health, sleep, and lifestyle survey. The enrolled subjects will have the UNEEG™ SubQ implanted and after approximately 10 days of healing the study subjects will start wearing the external part of the 24/7 EEG™ SubQ. Throughout the study the subjects will wear an ActiGraph, fill out a sleep diary and conduct cognitive tests. The duration of the study from screening to removal of sutures will be approximately 58 weeks.

Conditions

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Sleep

Keywords

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Circadian Chronobiology Sleep quality Automated sleep staging Implantable device

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Primary Study Purpose

DIAGNOSTIC

Blinding Strategy

NONE

Study Groups

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Healthy adults

UNEEG™ medical 24/7 EEG™ SubQ

Group Type EXPERIMENTAL

24/7 EEG™ SubQ

Intervention Type DIAGNOSTIC_TEST

24/7 EEG™ SubQ device will be worn by each subject for 365 nights

Interventions

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24/7 EEG™ SubQ

24/7 EEG™ SubQ device will be worn by each subject for 365 nights

Intervention Type DIAGNOSTIC_TEST

Eligibility Criteria

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Inclusion Criteria

* Age ≥18 years
* Subjects must be of general good health

Exclusion Criteria

* Has cochlear implants.
* Involved in therapies with medical devices that deliver electrical energy into the area around the implant
* Is at high risk of surgical complications, such as active systemic infection and hemorrhagic disease.
* Are unable (i.e. mentally or physically impaired patient), or do not have the necessary assistance, to properly operate the device system.
* Has an infection at the site of device implantation.
* Operates MRI scanners.
* Has a profession/hobby that includes activity imposing extreme pressure variations (e.g. diving or parachute jumping). N.B.: diving/snorkeling is allowed to 5 meters depth.
* Has a profession/hobby that includes activity imposing an unacceptable risk for trauma against the device or the site of implantation (e.g. martial art or boxing).
* Previous stroke or cerebral hemorrhage and any other structural cerebral disease.
* Ongoing or history of sleep disorders.
* Known neurological diseases.
* Known or suspected abuse of alcohol defined as estimated consumption beyond that, which is recommended by the Danish Health Authority or any other neuro-active substances.
* Other known diseases or conditions, judged by investigator to influence sleep to such a degree that data quality will be compromised.
* Medication judged by investigator to influence sleep to such a degree that data quality will be compromised.
* Incapable, judged by the investigator, of understanding the participant instruction or who are not capable of carrying through the investigation.
* Pregnancy or intention to become pregnant within the next 12 months.
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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Zealand University Hospital

OTHER

Sponsor Role collaborator

Cambridge Cognition Ltd

INDUSTRY

Sponsor Role collaborator

UNEEG Medical A/S

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Troels W Kjær, Professor

Role: PRINCIPAL_INVESTIGATOR

Zealand University Hospital

Locations

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Zealand University Hospital

Roskilde, , Denmark

Site Status

Countries

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Denmark

References

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Ahrens E, Jennum P, Duun-Henriksen J, Djurhuus B, Homoe P, Kjaer TW, Hemmsen MC. Automatic sleep staging based on 24/7 EEG SubQ (UNEEG medical) data displays strong agreement with polysomnography in healthy adults. Sleep Health. 2024 Dec;10(6):612-620. doi: 10.1016/j.sleh.2024.08.007. Epub 2024 Oct 15.

Reference Type DERIVED
PMID: 39406630 (View on PubMed)

Other Identifiers

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U003

Identifier Type: -

Identifier Source: org_study_id