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Comparison of Extra Vascular Lung Water Index in Covid-19 ARDS and "Typical"ARDS Patients

NCT ID: NCT04508933

Last Updated: 2021-10-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

WITHDRAWN

Study Classification

OBSERVATIONAL

Study Start Date

2020-09-01

Study Completion Date

2020-12-31

Brief Summary

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Covid-19 also primarily affects endothelium that line up the alveoli. The resulting hypoxemia may differ from "typical" Acute Respiratory Distress Syndrome (ARDS) due to maldistribution of perfusion related to the ventilation. Thus, pathophysiology of Covid-19 ARDS is different, which requires different interventions than typical ARDS. The investigators will assess whether extravascular lung water index and permeability of the alveolar capillary differs from typical ARDS with transpulmonary thermodilution (TPTD) technique. Extravascular Lung Water Index (EVLWI) and Pulmonary Vascular Permeability Index (PVPI) will be compared.

Detailed Description

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Conditions

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Respiratory Distress Syndrome, Adult Ventilation Perfusion Mismatch Pulmonary Edema Covid19

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Typical ARDS

ARDS due to non Covid19 causes

Extravascular Lung Water Index

Intervention Type DEVICE

Measurement of the EVLWI

Pulmonary Vascular Permeability Index

Intervention Type DEVICE

Measurement of the PVPI

C-ARDS

ARDS due to Covid19

Extravascular Lung Water Index

Intervention Type DEVICE

Measurement of the EVLWI

Pulmonary Vascular Permeability Index

Intervention Type DEVICE

Measurement of the PVPI

Interventions

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Extravascular Lung Water Index

Measurement of the EVLWI

Intervention Type DEVICE

Pulmonary Vascular Permeability Index

Measurement of the PVPI

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* ARDS defined by Berlin Criteria longer than 24 hours
* Undergoing mechanical ventilation
* Noradrenaline demand \>0.1 mcg/kg/min

Exclusion Criteria

* Not meeting ARDS criteria
* Noninvasive mechanical ventilation
* ARDS resolved shorter than 24 hours
* Shock resolved
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Istanbul University - Cerrahpasa

OTHER

Sponsor Role lead

Responsible Party

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Olcay Dilken

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Yalım Dikmen, Prof

Role: STUDY_DIRECTOR

Istanbul University-Cerrahpaşa, Cerrahpaşa Faculty of Medicine

Locations

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Istanbul University-Cerrahpaşa

Istanbul, , Turkey (Türkiye)

Site Status

Countries

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Turkey (Türkiye)

References

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Monnet X, Teboul JL. Transpulmonary thermodilution: advantages and limits. Crit Care. 2017 Jun 19;21(1):147. doi: 10.1186/s13054-017-1739-5.

Reference Type RESULT
PMID: 28625165 (View on PubMed)

Other Identifiers

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0308202247

Identifier Type: -

Identifier Source: org_study_id