OMNI in Open-angle Glaucoma Treatment

NCT ID: NCT04503356

Last Updated: 2020-08-11

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Clinical Phase

NA

Total Enrollment

17 participants

Study Classification

INTERVENTIONAL

Study Start Date

2018-04-17

Study Completion Date

2021-12-31

Brief Summary

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This single-center, prospective study will assess safety and effectiveness of 360 degree viscodilation followed by up to 360 degree trabeculotomy used in patients with early or moderate open-angle glaucoma in a real-world setting either as a standalone procedure in pseudophakic patients (or phakic) or combined with phacoemulsification cataract procedures.

Medication usage, IOP and secondary surgical procedures necessary for IOP control will be analyzed during the follow-up period.

Detailed Description

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Conditions

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Open Angle Glaucoma Cataract Eye Diseases Glaucoma

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

To prospectively assess the clinical effect of ab-interno transluminal viscodilation and trabeculotomy performed using the OMNI Surgical System as a standalone procedure or in combination with cataract extraction on intraocular pressure (IOP) and the use of ocular hypotensive medications in patients with open-angle glaucoma (OAG).
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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OMNI as a standalone procedure

Group Type ACTIVE_COMPARATOR

OMNI as a standalone procedure

Intervention Type PROCEDURE

It uses a single, self-sealing clear corneal incision with ab-interno transluminal 360 degree viscodilation of Schlemm's canal followed by up to 360 degree trabeculotomy performed using the OMNI Surgical System as a standalone procedure.

OMNI combined with cataract surgery

Group Type ACTIVE_COMPARATOR

OMNI combined with cataract surgery

Intervention Type PROCEDURE

Phacoemulsification with intraocular lens implantation is performed. Then, ab-interno transluminal 360 degree viscodilation of Schlemm's canal followed by up to 360 degree trabeculotomy performed using the OMNI Surgical System.

Interventions

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OMNI as a standalone procedure

It uses a single, self-sealing clear corneal incision with ab-interno transluminal 360 degree viscodilation of Schlemm's canal followed by up to 360 degree trabeculotomy performed using the OMNI Surgical System as a standalone procedure.

Intervention Type PROCEDURE

OMNI combined with cataract surgery

Phacoemulsification with intraocular lens implantation is performed. Then, ab-interno transluminal 360 degree viscodilation of Schlemm's canal followed by up to 360 degree trabeculotomy performed using the OMNI Surgical System.

Intervention Type PROCEDURE

Eligibility Criteria

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Inclusion Criteria

* diagnosed with open-angle glaucoma including pigmentary and pseudoexfoliative glaucoma
* 0-3 topical ocular hypotensive medications at preoperative baseline. Fixed combinations counted as number of components
* Open angles (Shaffer grade ≥3)
* early or moderate glaucoma (based on visual field)
* Subjects with a combined procedure should have had uncomplicated cataract surgery (i.e. intact and centered capsulorrhexis, intact posterior capsular bag, no evidence of zonular dehiscence or rupture, well centered IOL)

Exclusion Criteria

* Any of the following prior treatments for glaucoma:

* Suprachoroidal stent
* Laser trabeculoplasty ≤6 months prior to OMNI procedure
* Trabecular bypass implanted ≤6 months prior to OMNI procedure
* Trabeculectomy or other bleb forming procedure including Xen, Express, glaucoma draining device/valve
* Prior canaloplasty, goniotomy, or trabeculotomy
* Forms of glaucoma other than OAG including: acute angle closure, traumatic, congenital, malignant, uveitic or neovascular glaucoma
* Under treatment with oral carbonic anhydrase inhibitor at the preoperative visit
* Clinically significant ocular pathology, other than age-related cataract and glaucoma. (e.g. wet AMD, uveitis, corneal edema, proliferative diabetic retinopathy, optic neuritis in medical history)
Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Centre of Postgraduate Medical Education

OTHER

Sponsor Role lead

Responsible Party

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Iwona Grabska- Liberek

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Iwona Grabska-Liberek, MD, PhD

Role: PRINCIPAL_INVESTIGATOR

Ophthalmology Clinic Centre of Postgraduate Medical Education, Warsaw, Poland

Locations

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Orlowski Hospital, Centre of Postgraduate Medical Education

Warsaw, , Poland

Site Status

Countries

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Poland

Other Identifiers

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44/PB/2018

Identifier Type: -

Identifier Source: org_study_id

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