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Association Between Tendon-related Transcription Factor and Ultrasound Images and Shoulder Function

NCT ID: NCT04502134

Last Updated: 2020-11-23

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

UNKNOWN

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2019-11-30

Study Completion Date

2021-09-30

Brief Summary

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The purpose of this project is to extract effusions and damaged tendons during tendon repair therapy in patients with tendon tears. Then, we would analyze tendon-related transcription factors from histology and cytology, and compare changes in tendon with ultrasound images. Helps to understand the mechanism of tendon lesions.

Detailed Description

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According to past studies, it is often observed that changes in extracellular matrix, growth factors, and cytokines in degenerative tendons, indicating that the tendon is constantly changing. This change will in turn produce a change in the morphology of the tendon tissue in the ultrasound image. However, there have been few studies in the past literature on the correlation between constant changes in tendon-specific transcription factors and characterization on clinical ultrasound images. Therefore, the purpose of this project is to extract the effusion and damaged tendon while performing tendon repair therapy in patients with tendon tears, and to analyze the tendon-related transcription factors from histology and cytology to understand the changes in tendon homeostasis. At the same time, the interpretation of clinical ultrasound images was combined to establish the relationship between the biochemical factors of the cell tissues of chronic tendon lesions and the clinical ultrasound image. This study will help us to understand the mechanism of chronic tendinopathy.

Conditions

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Rotator Cuff Tears Rotator Cuff Tendinosis

Keywords

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ultrasonography rotator cuff tendinopathy

Study Design

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Observational Model Type

OTHER

Study Time Perspective

CROSS_SECTIONAL

Eligibility Criteria

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Inclusion Criteria

* age older than 20 y
* shoulder pain more than 3 months and Visual Analogue Scale (VAS) \>4
* shoulder tendon defect on ultrasound images

Exclusion Criteria

* diagnosis of cervical radiculopathy or other central or peripheral neuropathy
* rheumatoid arthritis or other autoimmune diseases
* have received any shoulder joint injection within three months
* tumor or systematic inflammation
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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National Taiwan University Hospital

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Locations

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National Taiwan University Hospital

Taipei, , Taiwan

Site Status RECRUITING

Countries

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Taiwan

Central Contacts

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Chao Yuan-Hung, PhD

Role: CONTACT

Phone: 0933121572

Email: [email protected]

Facility Contacts

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Chao Yuan-Hung, PhD

Role: primary

Other Identifiers

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201910004RIND

Identifier Type: -

Identifier Source: org_study_id