Role of Suppression of Endometriosis With Progestins Before IVF-ET
NCT ID: NCT04500743
Last Updated: 2020-08-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
NA
134 participants
INTERVENTIONAL
2018-08-01
2020-04-30
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Dienogest
Dienogest
Group B (n=67) who had daily oral Dienogest 2 mg/d for 3 months before starting standard long protocol for IVF
GnRH analogue
leuprorelin acetate
Group A (n=67) who had monthly depot GnRHa for 3 months before ovarian stimulation in IVF treatment (Ultra-long protocol)
Interventions
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Dienogest
Group B (n=67) who had daily oral Dienogest 2 mg/d for 3 months before starting standard long protocol for IVF
leuprorelin acetate
Group A (n=67) who had monthly depot GnRHa for 3 months before ovarian stimulation in IVF treatment (Ultra-long protocol)
Eligibility Criteria
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Inclusion Criteria
* body mass index \< 35 Kg/m2
Exclusion Criteria
* liver or kidney disease
* evidence of diminished ovarian reserve (e.g. high FSH level \>12 IU/L or low AMH level \<1 ng/ml).
30 Years
40 Years
FEMALE
Yes
Sponsors
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National Research Centre, Egypt
OTHER
Responsible Party
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Mazen Abdel Rasheed
Principal Investigator
Locations
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Minia Infertility research unit
Minya, , Egypt
Countries
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References
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Chen I, Kives S, Zakhari A, Nguyen DB, Goldberg HR, Choudhry AJ, Le AL, Kowalczewski E, Schroll JB. Progestagens for pain symptoms associated with endometriosis. Cochrane Database Syst Rev. 2025 Oct 9;10:CD002122. doi: 10.1002/14651858.CD002122.pub3.
Khalifa E, Mohammad H, Abdullah A, Abdel-Rasheed M, Khairy M, Hosni M. Role of suppression of endometriosis with progestins before IVF-ET: a non-inferiority randomized controlled trial. BMC Pregnancy Childbirth. 2021 Mar 30;21(1):264. doi: 10.1186/s12884-021-03736-2.
Other Identifiers
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Dienogest before IVF
Identifier Type: -
Identifier Source: org_study_id
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