Effect of Non-eugenol Periodontal Pack With and Without PRF on Post-operative Pain and Wound Healing After Gingival Depigmentation
NCT ID: NCT04495205
Last Updated: 2020-07-31
Study Results
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Basic Information
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UNKNOWN
EARLY_PHASE1
24 participants
INTERVENTIONAL
2020-01-01
2021-03-31
Brief Summary
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Dental cosmetic procedures including gingival depigmentation among the young generation are vastly becoming popular due to the public advertising of what the "ideal smile" should be. This means that brown/ pigmented gingiva is not esthetically accepted by modern standards. Numerous techniques for depigmentation were developed including surgical abrasion, lasers, chemicals and thermal techniques.
The use of post-operative non-eugenol containing periodontal packs acts as a mechanical barrier for coverage of the denuded area which prevents bleeding and promotes healing by preventing trauma to the area.
Platelet Rich Fibrin (PRF) is a form of concentrated suspension of growth factors that promote healing and tissue regeneration. Its use in the medical and dental fields is expanding during the recent year.
Detailed Description
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However, a review article discussed the adverse effects of periodontal pack as it may cause plaque induced inflammation, patient discomfort due to difficulty in eating and irritation of the tissues. In the article, there were clinical trials that advocated that wound healing could occur without the need of periodontal pack if the surgical wound was kept clean alone indicating that the pack does not affect the wound healing.
This gave rise to idea to use a material that has been proven to accelerate wound healing and decrease the patient discomfort to be placed under the periodontal pack which would be used only as a protective barrier.
Several studies tested platelet rich concentrates as adjunctive methods under periodontal packs verses periodontal packs alone after surgical abrasion of gingival depigmentation. They found that there was a clinical, histological and statistical difference between the groups favoring the platelet concentrate groups.
Using PRF which is a second generation platelet concentrate first developed by Choukroun et al in 2001 used as a membrane could provide accelerated wound healing properties which would accelerate ginigival re-epithelization . Using a periodontal pack is conventionally used which will provide a mechanical barrier to protect the wound from any stimulus.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
SUPPORTIVE_CARE
DOUBLE
Study Groups
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Non-eugenol containing periodontal packs with PRF
Non-eugenol containing periodontal packs with PRF after gingival de-pigmentation
PRF under non-eugenol containing periodontal pack
Platelet Rich Fibrin under non-eugenol containing periodontal pack
Non-eugenol containing periodontal packs
Non-eugenol containing periodontal packs after gingival de-pigmentation
Non-eugenol containing periodontal pack
Non-eugenol containing periodontal pack after gingival depigmentation
Interventions
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PRF under non-eugenol containing periodontal pack
Platelet Rich Fibrin under non-eugenol containing periodontal pack
Non-eugenol containing periodontal pack
Non-eugenol containing periodontal pack after gingival depigmentation
Other Intervention Names
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Eligibility Criteria
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Inclusion Criteria
* Systemically healthy
* Mild to moderate gingival pigmentations
* Gingival and plaque index \<1
* Good oral hygiene
* Thick gingival biotypes
* Keratinized gingiva \>2mm
Exclusion Criteria
* Taking any medications that could affect healing
* Pervious depigmentation procedures
* Pregnant or lactating females
* Pervious periodontal surgery within the last 6 months before the start of the trial
* Endodontically treated teeth
18 Years
40 Years
ALL
Yes
Sponsors
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Cairo University
OTHER
Responsible Party
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Aya Hesham Reda
Masters Student
Locations
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Cairo University Faculty of Dentistry
Cairo, , Egypt
Countries
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Facility Contacts
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Mona S Darhous, Professor
Role: primary
References
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Dahiya R, Blaggana A, Panwar V, Kumar S, Kathuria A, Malik S. Clinical and histological comparison of platelet-rich fibrin versus non-eugenol periodontal dressing in the treatment of gingival hyperpigmentation. J Indian Soc Periodontol. 2019 Jul-Aug;23(4):345-350. doi: 10.4103/jisp.jisp_688_18.
Other Identifiers
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AHReda
Identifier Type: -
Identifier Source: org_study_id