A Multivariate Index Assay for Ovarian Cancer Risk Assessment in Women With Adnexal Mass and High-Risk Germline Variants

NCT ID: NCT04487405

Last Updated: 2023-12-26

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

TERMINATED

Total Enrollment

721 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-06-25

Study Completion Date

2023-12-15

Brief Summary

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The objective of this project is to validate the sensitivity, specificity, positive predictive value and negative predictive values of the AMRA blood test for assessing risk of cancer in women at high risk for ovarian cancer, due to the presence of a symptomatic adnexal mass.

Detailed Description

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Conditions

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Adnexal Mass

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

PROSPECTIVE

Study Groups

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Group A

Symptomatic with adnexal mass

OVAnex

Intervention Type DEVICE

OVAnex is a multivarite index assay assessing ovarian cancer risk

Group B

Asymptomatic with adnexal mass

OVAnex

Intervention Type DEVICE

OVAnex is a multivarite index assay assessing ovarian cancer risk

Group C

Women with a predisposition in developing ovarian cancer due to a positive, pathogenic variant

OVAnex

Intervention Type DEVICE

OVAnex is a multivarite index assay assessing ovarian cancer risk

Interventions

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OVAnex

OVAnex is a multivarite index assay assessing ovarian cancer risk

Intervention Type DEVICE

Eligibility Criteria

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Inclusion Criteria

* Female patient, 18 years of age or older diagnosed with an ovarian adnexal mass, or in follow-up due to the presence of BRCA1/2 and other germline DNA variants.
* Patient reviewed, understood, and provided the PI with written informed consent to allow blood specimen to be used for research and release of medical information.

Exclusion Criteria

* Patient is less than 18 years of age
* Patient is not being treated in the U.S.
Minimum Eligible Age

18 Years

Eligible Sex

FEMALE

Accepts Healthy Volunteers

No

Sponsors

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Aspira Women's Health

INDUSTRY

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Todd Pappas, PhD

Role: PRINCIPAL_INVESTIGATOR

Aspira Women's Health

Locations

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Women's Health Arizona

Chandler, Arizona, United States

Site Status

Altus Research

Lake Worth, Florida, United States

Site Status

MidTown OBGYN

Columbus, Georgia, United States

Site Status

Premier OBGYN of Minnesota

Eden Prairie, Minnesota, United States

Site Status

Square Care Health

New Hyde Park, New York, United States

Site Status

Northwell Health

New Hyde Park, New York, United States

Site Status

Seven Hills Clinical Research Group

Cincinnati, Ohio, United States

Site Status

May Grant OB/GYN

Lancaster, Pennsylvania, United States

Site Status

Hill Country OBGYN Associates

Austin, Texas, United States

Site Status

Countries

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United States

Other Identifiers

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04-2019

Identifier Type: -

Identifier Source: org_study_id