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The Next Leap in Cardiac Magnetic Resonance Imaging:Cycling the Field

NCT ID: NCT04458883

Last Updated: 2024-12-24

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Clinical Phase

NA

Total Enrollment

150 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-08-01

Study Completion Date

2025-07-31

Brief Summary

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The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.

Detailed Description

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Aberdeen scientists are at the forefront of a new type of magnetic resonance imaging (MRI), having built in-house the only two available prototypes of Fast Field-Cycling MRI in the world - and these already have clinical imaging capabilities. Fast Field-Cycling MRI switches rapidly over a range of field strengths (0.2 T to 200 µT), providing a T1 dispersion curve. This information is invisible to fixed-field scanners and uncovers unique knowledge about motion and interaction between component molecules within a tissue (i.e. water/fat/proteins). In this application the investigators wish to use their in-house expertise further to extend the capability of our Fast Field-Cycling MRI to perform cardiac imaging by building the first-ever cardiac Fast Field-Cycling MRI coil and develop cardiac pulse sequences with ECG gating. The investigators will aim to establish the normalcy of T1 dispersion curves for left ventricular myocardium in healthy volunteers, and further on to distinguish the characteristics of post-myocardial infarction scar T1 dispersion curves.

Conditions

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Myocardial Infarction

Study Design

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Allocation Method

NON_RANDOMIZED

Intervention Model

PARALLEL

The main aim of the study is to build and test a cardiac-specific coil purposely assembled in house to suit the FFC-MRI whole-body prototype and to test if it could be used for clinical cardiac scans in human subject populations.
Primary Study Purpose

BASIC_SCIENCE

Blinding Strategy

NONE

Study Groups

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Myocardial Infarction Group

Patients diagnosed with a myocardial infarction

Group Type EXPERIMENTAL

Cardiac Magnetic Resonance Imaging

Intervention Type PROCEDURE

Cardiac Magnetic Resonance Imaging - Cardiac Scan

Fast Field Cycling - Magnetic Resonance Imaging

Intervention Type PROCEDURE

Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan

Healthy Volunteers

Healthy Volunteers

Group Type EXPERIMENTAL

Cardiac Magnetic Resonance Imaging

Intervention Type PROCEDURE

Cardiac Magnetic Resonance Imaging - Cardiac Scan

Fast Field Cycling - Magnetic Resonance Imaging

Intervention Type PROCEDURE

Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan

Electrocardiogram

Intervention Type PROCEDURE

Electrocardiogram

Echocardiogram

Intervention Type PROCEDURE

Echocardiogram

Interventions

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Cardiac Magnetic Resonance Imaging

Cardiac Magnetic Resonance Imaging - Cardiac Scan

Intervention Type PROCEDURE

Fast Field Cycling - Magnetic Resonance Imaging

Fast Field Cycling - Magnetic Resonance Imaging Cardiac Scan

Intervention Type PROCEDURE

Electrocardiogram

Electrocardiogram

Intervention Type PROCEDURE

Echocardiogram

Echocardiogram

Intervention Type PROCEDURE

Other Intervention Names

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ECG

Eligibility Criteria

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Inclusion Criteria

* Participant who is willing and able to give informed consent for participation in the study
* Healthy volunteers willing to give informed consent for participation in the study
* Patients diagnosed with a previous myocardial infarction

Exclusion Criteria

* Unwillingness to participate
* Claustrophobia
* Contraindication to MRI scanning such as implantable cardiac devices
* Participants who have had a previous myocardial infarction in the past of which they may not be aware and this is discovered whilst being scanned on the 3T MRI scanner, or who may have any other cardiology condition that they were previously unaware will not be included in the healthy control group, even if they present themselves to us as "healthy" at the time of the study visit
* Pregnancy
* Body habitus that may preclude comfortable positioning of the volunteer in either of the MRI scanners (\>50cm in diameter)
* Participants with abnormal kidney function that will preclude them from receiving a contrast agent
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Aberdeen

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Dana Dawson, DPhil

Role: PRINCIPAL_INVESTIGATOR

University of Aberdeen

Locations

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Cardiovascular Research Facility

Aberdeen, Aberdeenshire, United Kingdom

Site Status RECRUITING

University of Aberdeen and NHS Grampian

Aberdeen, Aberdeenshire, United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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James Ross, PhD

Role: CONTACT

Phone: 01224437832

Email: [email protected]

Amelia Rudd, MSc

Role: CONTACT

Phone: 01224559473

Email: [email protected]

Facility Contacts

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Amelia Rudd, MSc

Role: primary

James Ross, PhD

Role: backup

Stacey Dawson

Role: primary

References

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Broche LM, Ross PJ, Pine KJ, Lurie DJ. Rapid multi-field T(1) estimation algorithm for Fast Field-Cycling MRI. J Magn Reson. 2014 Jan;238:44-51. doi: 10.1016/j.jmr.2013.10.010. Epub 2013 Oct 31.

Reference Type BACKGROUND
PMID: 24309067 (View on PubMed)

Kimmich R, Nusser W, Winter F. In vivo NMR field-cycling relaxation spectroscopy reveals 14N1H relaxation sinks in the backbones of proteins. Phys Med Biol. 1984 May;29(5):593-6. doi: 10.1088/0031-9155/29/5/011. No abstract available.

Reference Type BACKGROUND
PMID: 6739544 (View on PubMed)

Broche LM, Ismail SR, Booth NA, Lurie DJ. Measurement of fibrin concentration by fast field-cycling NMR. Magn Reson Med. 2012 May;67(5):1453-7. doi: 10.1002/mrm.23117. Epub 2011 Oct 24.

Reference Type BACKGROUND
PMID: 22025420 (View on PubMed)

Broche LM, Ashcroft GP, Lurie DJ. Detection of osteoarthritis in knee and hip joints by fast field-cycling NMR. Magn Reson Med. 2012 Aug;68(2):358-62. doi: 10.1002/mrm.23266. Epub 2011 Dec 12.

Reference Type BACKGROUND
PMID: 22161576 (View on PubMed)

Scally C, Abbas H, Ahearn T, Srinivasan J, Mezincescu A, Rudd A, Spath N, Yucel-Finn A, Yuecel R, Oldroyd K, Dospinescu C, Horgan G, Broadhurst P, Henning A, Newby DE, Semple S, Wilson HM, Dawson DK. Myocardial and Systemic Inflammation in Acute Stress-Induced (Takotsubo) Cardiomyopathy. Circulation. 2019 Mar 26;139(13):1581-1592. doi: 10.1161/CIRCULATIONAHA.118.037975.

Reference Type BACKGROUND
PMID: 30586731 (View on PubMed)

Antonopoulos AS, Sanna F, Sabharwal N, Thomas S, Oikonomou EK, Herdman L, Margaritis M, Shirodaria C, Kampoli AM, Akoumianakis I, Petrou M, Sayeed R, Krasopoulos G, Psarros C, Ciccone P, Brophy CM, Digby J, Kelion A, Uberoi R, Anthony S, Alexopoulos N, Tousoulis D, Achenbach S, Neubauer S, Channon KM, Antoniades C. Detecting human coronary inflammation by imaging perivascular fat. Sci Transl Med. 2017 Jul 12;9(398):eaal2658. doi: 10.1126/scitranslmed.aal2658.

Reference Type BACKGROUND
PMID: 28701474 (View on PubMed)

Other Identifiers

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2-010-20

Identifier Type: -

Identifier Source: org_study_id