Proton Beam Therapy for Unresectable Liver Metastasis

NCT ID: NCT04456621

Last Updated: 2023-11-22

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

NA

Total Enrollment

66 participants

Study Classification

INTERVENTIONAL

Study Start Date

2019-01-01

Study Completion Date

2021-07-31

Brief Summary

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The investigators performed the present study to evaluate the role of proton beam therapy for liver metastasis which is unresectable and unsuitable for radiofrequency ablation (RFA) in terms of local control and safety.

Detailed Description

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Conditions

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Local Control Rate Side Effect

Study Design

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Allocation Method

NA

Intervention Model

SINGLE_GROUP

Proton beam radiotherapy : 5 fractions of 12 GyRBE or 10 fractions of 7 GyRBE
Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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PBT arm

Group Type EXPERIMENTAL

PBT

Intervention Type RADIATION

Proton beam radiotherapy 70 gray relative biological equivalent (GyRBE)/10 fractions (Fx) or 60 GyRBE/5 Fx

Interventions

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PBT

Proton beam radiotherapy 70 gray relative biological equivalent (GyRBE)/10 fractions (Fx) or 60 GyRBE/5 Fx

Intervention Type RADIATION

Eligibility Criteria

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Inclusion Criteria

* pathologically diagnosed cancer patient
* confirmed liver metastasis via computed tomography (CT) or magnetic resonance imaging (MRI) or biopsy
* unresectable or unsuitable for RFA
* solitary liver metastasis or less than 3 metastatic lesions if the distance is less than 3 cm between metastatic lesions
* case discussed by surgeon, radiologist, and radiation oncologist
* Eastern cooperative oncology group performance status 0 to 2
* optimal liver and renal function (Child-Pugh score 10 or less)
* informed consent
* agree to be contraceptive for the duration of the study and for the next 6 months

Exclusion Criteria

* uncontrolled ascites or hepatorenal syndrome
* status of pregnancy or breast-feeding
* less than 12 weeks of expected survival
* combined disease known to have high radiation side effects
* serious acute illness that is not treated other than liver disease
Minimum Eligible Age

20 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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Samsung Medical Center

OTHER

Sponsor Role lead

Responsible Party

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Park Hee Chul

Professor

Responsibility Role PRINCIPAL_INVESTIGATOR

Locations

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Samsung Medical Center

Seoul, , South Korea

Site Status

Countries

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South Korea

Other Identifiers

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2018-10-048

Identifier Type: -

Identifier Source: org_study_id