Comparison of Vortioxetine and Desvenlafaxine in Adult Patients Suffering From Depression
NCT ID: NCT04448431
Last Updated: 2022-02-14
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE4
605 participants
INTERVENTIONAL
2020-06-18
2022-02-04
Brief Summary
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Detailed Description
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At Baseline, patients will be equally randomised (1:1) to 1 of the 2 treatment groups for an 8-week, double-blind Treatment Period.
Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
DOUBLE
Study Groups
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Vortioxetine
8 weeks treatment
Vortioxetine
10 or 20 mg/day, capsules, orally
Desvenlafaxine
8 weeks treatment
Desvenlafaxine
50 mg/day capsules, orally
Interventions
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Vortioxetine
10 or 20 mg/day, capsules, orally
Desvenlafaxine
50 mg/day capsules, orally
Eligibility Criteria
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Inclusion Criteria
* The patient has a MADRS total score ≥24 at screening and baseline.
* The patient has had the current MDE for ≥3 months and \< 12 months.
* The patient has been treated with an SSRI as monotherapy (citalopram, escitalopram, paroxetine, sertraline) for at least 6 weeks at licensed dose for the current MDE with a partial response and is a candidate for a switch in the investigator's opinion.
* The patient wants to switch antidepressant treatment.
Exclusion Criteria
18 Years
65 Years
ALL
No
Sponsors
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H. Lundbeck A/S
INDUSTRY
Responsible Party
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Principal Investigators
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Locations
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Clinica Privada Banfield
Banfield, Buenos Aires, Argentina
Cenydet-Centro Neurobiologico Y De Estres Traumatico-Biopsychomedical Research Group Srl
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Fundacion para el Estudio y Tratamiento de las enfermedades mentales FETEM
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
INAPsi (Instituto Nacional de Psicopatologia)
Ciudad Autonoma de Buenos Aires, Buenos Aires, Argentina
Clinica Privada De Salud Mental Santa Teresa De Avila
La Plata, Buenos Aires, Argentina
Instituto De Neurociencias San Agustin SA
La Plata, Buenos Aires, Argentina
Sanatorio Prof. Leon S. Morra S.A.
Córdoba, Providencia de Cordo, Argentina
CIAP (Centro de Investigacion y Asistencia en Psiquiatria)
Rosario, Santa Fe Province, Argentina
CINME (Centro de Investigaciones Metabolicas de Buenos Aires)
Buenos Aires, , Argentina
CEN (Centro Especializado Neurociencias)
Córdoba, , Argentina
Instituto Modelo de Neurologia Fundacion Lennox
Córdoba, , Argentina
Instituto Medico DAMIC - Fundacion Rusculleda
Córdoba, , Argentina
Centro De Asistencia E Investigacion En Neurociencias CENAIN
Mendoza, , Argentina
Resolution Psicopharmacology Research Institute
Mendoza, , Argentina
Algemeen Ziekenhuis St. Lucas-St. Jozef
Bruges, , Belgium
SINAPS - University Antwerpe- Psychiatrisch Ziekenhuis Duffel
Duffel, , Belgium
Cliniques De Mont-Godinne
Yvoir, , Belgium
MHAT Dr. Hristo Stambolski
Kazanlak, , Bulgaria
UMHAT Sv. Ivan Rilski EAD
Plovdiv, , Bulgaria
Center For Mental Health-Rousse
Rousse, , Bulgaria
MC Complete Medical Solutions
Samokov, , Bulgaria
Centre for Mental Health- Sofia
Sofia, , Bulgaria
Diagnostic Consultative Center Mladost-M Varna OOD
Varna, , Bulgaria
Clintrial s.r.o.
Prague, Prague 10, Czechia
Dr.Jan Holan MD, Office of
Brno, , Czechia
Meditrine s.r.o. - Psychiatricka Ambulance, Lecebne Centrum
Havířov, , Czechia
Clinline services s.r.o.
Hostivice, , Czechia
Neuropsychiatrie HK, s.r.o.
Hradec Králové, , Czechia
National Institute of Mental Health
Klecany, , Czechia
Psychiatricka Ambulance
Kutná Hora, , Czechia
A-Shine s.r.o.
Pilsen, , Czechia
Institut neuropsychiatricke pece
Prague, , Czechia
Marienthali Kliinik
Tallinn, , Estonia
Psihiatrijas Centrs
Liepāja, Liepajas Rajons, Latvia
Riga Centre Of Psychiatry And Addiction Disorders
Riga, , Latvia
Sigulda Hospital Outpatient Clinic
Sigulda, , Latvia
CRI Centro Regiomontano de Investigacion SC
Monterrey, Nuevo León, Mexico
Medical Care and Research S.A. de C.V.
Mérida, Yucatán, Mexico
Health Pharma Professional Research S.A. de C.V.
Mexico City, , Mexico
Region Specialized Psychiatric Hospital No.2
Stavropol Region, Kochubeev District, Russia
Leningrad Regional Psychoneurological Dispensary
Roshchino, Leningradskaya Oblast', Russia
Arkhangelsk Regional Clinical Mental Hospital
Arkhangelsk, , Russia
GUZ Engels Psychiatric Hospital
Engel's, , Russia
Moscow Scientific Research Institute of Psychiatry
Moscow, , Russia
Clinic named after professor Yu. N. Kasatkin FGBOU DPO RMANPO Minzdrava Rossii
Moscow, , Russia
Nizhny Novgorod Region State Institution Of Healthcare Clinical Psychiatric Hospital 1 Of Nizhny ...
Nizhny Novgorod, , Russia
Rostov State Medical University of the Minzdravsotsrazvitiya of Russia
Rostov-on-Don, , Russia
LLC Medical Center Nova Vita
Rostov-on-Don, , Russia
St. Nicolas State Psychiatric Hospital
Saint Petersburg, , Russia
Hospital OrKli , LLC
Saint Petersburg, , Russia
LLC Astarta
Saint Petersburg, , Russia
Saratov State Medical University
Saratov, , Russia
State Budgetery Educational Institution Of Higher Professional Education Smolensk State Medical U...
Smolensk, , Russia
Yaroslavl Regional Clinical Psychiatry Hospital
Yaroslavl, , Russia
Psychiatricka ambulancia, MENTUM, s.r.o.
Bratislava, , Slovakia
Epamed, S.R.O
Košice, , Slovakia
Psycholine S.R.O.
Rimavská Sobota, , Slovakia
Crystal Comfort, s.r.o.
Vranov Nad Topou, , Slovakia
BONA MEDIC s.r.o.
Zlaté Moravce, , Slovakia
Psychiatricka Ambulancia
Zlaté Moravce, , Slovakia
Hospital Universitario Fundacion Alcorcon
Alcorcón, Madrid, Spain
Centro De Salud Mental La Corredoria
Oviedo, Principality of Asturias, Spain
Hospital De La Santa Creu I Sant Pau
Barcelona, , Spain
Hospital Psiquiatric de Palma de Mallorca
Palma de Mallorca, , Spain
Smaert & Psykiatricentrum Malmoe
Malmo, Skåne County, Sweden
Affecta Psyikiatri AB
Halmstad, , Sweden
ProbarE i Lund
Lund, , Sweden
ONE LIFETIME Lakarmottagning
Skövde, , Sweden
ProbarE
Stockholm, , Sweden
Communal Non-commercial Enterprise Cherkasy regional psychiatric hospital of Cherkasy regional co...
Smila, Cherkasy Oblast, Ukraine
Communal Non-Commercial Enterprise of Kharkiv Regional Council Regional clinical psychiatric hosp...
Kharkiv, Kharkivska, Ukraine
Municipal Non-profit Enterprise Odesa Regional Psychiatric Hospital No.2 of Odesa Regional Council
Kominternivskyy, Odesa Oblast, Ukraine
CI of KRC Regional psychiatric and narcological medical association
Hlevakha, , Ukraine
Ivano-Frankivsk Oblast neuropsychiatric hospital No. 3
Ivano-Frankivsk, , Ukraine
Academy of Medical Sciences of Ukraine - Institute of Neurology, Psychiatry and Narcology
Kharkiv, , Ukraine
SI INPN Namsu
Kharkiv, , Ukraine
Lviv Regional State Clinical Psychiatric Hospital, Lviv Danylo Galytsky National Medical University
Lviv, , Ukraine
Odessa Regional Medical Centre of Mental Health
Odesa, , Ukraine
Ukrainian Medical Stomatological Academy, Chair Of Psychiatry, Narcology And Medical Psychology B...
Poltava, , Ukraine
Vinnitsa National Medical University
Vinnitsa, , Ukraine
Countries
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References
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Gill H, McIntyre RS, Christensen MC. Analysis of reward behavior in patients with MDD and partial response to SSRI therapy treated with vortioxetine versus desvenlafaxine: Experience with the Effort-Expenditure for Rewards Task (EEfRT) in the VIVRE study. J Affect Disord. 2025 Nov 1;388:119563. doi: 10.1016/j.jad.2025.119563. Epub 2025 May 31.
McIntyre RS, Florea I, Pedersen MM, Christensen MC. Head-To-Head Comparison of Vortioxetine Versus Desvenlafaxine in Patients With Major Depressive Disorder With Partial Response to SSRI Therapy: Results of the VIVRE Study. J Clin Psychiatry. 2023 May 22;84(4):23m14780. doi: 10.4088/JCP.23m14780.
Other Identifiers
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18498A
Identifier Type: -
Identifier Source: org_study_id
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