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Biomedical Research Informatics Centre for Cardiovascular Sciences (The BRICCS Study)

NCT ID: NCT04388943

Last Updated: 2023-11-29

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

RECRUITING

Total Enrollment

9500 participants

Study Classification

OBSERVATIONAL

Study Start Date

2010-06-17

Study Completion Date

2027-03-31

Brief Summary

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This project will examine the diagnosis and prognosis of patients with cardiovascular disease in hospital in- and outpatients and compare their characteristics with normal controls from the community. The cardiovascular diseases studied include coronary artery disease, heart failure, heart attacks, valve disease, cardiac surgery, dysrhythmias, aneurysms, embolism, strokes, peripheral vascular disease and hypertension. Current methods for diagnosis and predicting outcome in patients are limited and may lack accuracy. This study will collect clinical details, and blood and urine samples from patients for analysis of proteins, chemicals and genetic biomarkers which will enable an examination of the pathological mechanisms involved in cardiovascular disease. The data will also be used to improve diagnosis and also improve prediction of outcome in patients (future clinical events such as death, further hospitalisation with cardiovascular disease and the effects of any therapy given to the patients). In this way, we can develop accurate ways of assessing a patient's condition and how it could be effectively managed. The study will last for 20 years.

Detailed Description

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Conditions

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Cardiovascular Diseases Cardiovascular Risk Factor

Study Design

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Observational Model Type

CASE_CONTROL

Study Time Perspective

RETROSPECTIVE

Study Groups

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1

Observation

Intervention Type OTHER

Physiological Measurements Patient reported questionnaire Blood sampling

Interventions

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Observation

Physiological Measurements Patient reported questionnaire Blood sampling

Intervention Type OTHER

Eligibility Criteria

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Inclusion Criteria

* All outpatients and inpatients with cardiovascular disease, of either gender
* Aged 18-90 years old
* Examples of conditions include: coronary artery disease, heart failure, heart attacks (myocardial infarction), valve disease, cardiac surgery, dysrhythmias (including atrial fibrillation), aneurysms, embolism, strokes, peripheral vascular disease, hypertension (and its complications, such as left ventricular hypertrophy) or those presenting with chest pain
* Healthy volunteers
* Aged 18-90 years old
* From the community without cardiovascular or other diseases

Exclusion Criteria

* Any patient who is unable to give consent
* Any patient with non-cardiovascular comorbidity likely to cause death within 6 months
* Patients know to be infected with HIV, Hepatitis B or any other agent posing an infection risk from unfixed material
Minimum Eligible Age

18 Years

Maximum Eligible Age

90 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

Yes

Sponsors

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University of Leicester

OTHER

Sponsor Role collaborator

University Hospitals, Leicester

OTHER

Sponsor Role lead

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Nilesh J Samani, Professor

Role: PRINCIPAL_INVESTIGATOR

NIHR Leicester Biomedical Research Centre

Locations

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University Hospitals Leicester

Leicester, , United Kingdom

Site Status RECRUITING

Countries

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United Kingdom

Central Contacts

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Emma P Beeston

Role: CONTACT

[email protected]
0116 204 4738

Tara Maitland

Role: CONTACT

[email protected]
0116 204 4737

Facility Contacts

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Emma P Beeston

Role: primary

Other Identifiers

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14022

Identifier Type: -

Identifier Source: org_study_id