Using Antibiotics Wisely - An Antimicrobial Stewardship Program
NCT ID: NCT04388293
Last Updated: 2021-12-28
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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UNKNOWN
2000 participants
OBSERVATIONAL
2020-01-01
2025-09-30
Brief Summary
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Detailed Description
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Hypothesis: The investigators expect to find:
* Significant national variation in broad-spectrum antimicrobial use, which will not be correlated with rates of sepsis. High antimicrobial consumption rates may be associated with limited existing ASP resources and increased neonatal morbidity related to inflammatory cascades.
* Significant national variation in the prevalence of MDROs across NICUs.
* Differences in empirical antimicrobial regimens may be associated with MDRO prevalence, and the variation in antimicrobial use may explain some variation in neonatal morbidity.
Study Population and Sample Size: The study population will include very-low-birth-weight (VLBW) infants (i.e., the group of infants neonates with the highest risk of infections within NICUs) admitted to participating tertiary NICUs in Canada.
Conditions
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Study Design
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COHORT
PROSPECTIVE
Interventions
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Exposure of interest
Very Low Birth Weight infants admitted to tertiary NICUs in Canada.
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
22 Weeks
44 Weeks
ALL
No
Sponsors
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University of Calgary
OTHER
University of Toronto
OTHER
Memorial University of Newfoundland
OTHER
Children's Hospital of Eastern Ontario
OTHER
Université de Montréal
OTHER
University of British Columbia
OTHER
Responsible Party
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Joseph Ting
Principal Investigator
Locations
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Royal Alexandra Hospital
Edmonton, Alberta, Canada
Countries
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Central Contacts
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Facility Contacts
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References
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Ting JY, Roberts A, Tilley P, Robinson JL, Dunn MS, Paquette V, Lee KS, Shah V, Yoon E, Richter LL, Lodha A, Shivananda S, Thampi N, Autmizguine J, Shah PS; Canadian Neonatal Network Investigators. Development of a national neonatal intensive care unit-specific antimicrobial stewardship programme in Canada: protocol for a cohort study. BMJ Open. 2020 Dec 10;10(12):e043403. doi: 10.1136/bmjopen-2020-043403.
Other Identifiers
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H19-02490
Identifier Type: -
Identifier Source: org_study_id
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