Effect of Hydration Guided by Vigileo on the Prevention of CIN After PCI for Patients With AMI
NCT ID: NCT04382313
Last Updated: 2023-01-04
Study Results
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Basic Information
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COMPLETED
NA
344 participants
INTERVENTIONAL
2020-07-10
2022-12-21
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
PREVENTION
SINGLE
Study Groups
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the adequate hydration group guided by Vigileo
The hydration speed is adjusted according to SVV or SV by Vigileo
the adequate hydration group guided by Vigileo
If the patient is mechanically ventilated, the following scheme is adopted: if SVV≤10%, then adjust the rehydration speed to 1 ml/kg/h; if 10%\<SVV\<15%, then adjust the rehydration speed to 2 ml/kg/h; if SVV≥15%, then adjust the rehydration speed to 3 ml/kg/h. The hydration lasts 24 hours after operation, and the rehydration speed is changed according to the SVV. If the patient does not use mechanical ventilation, the following scheme is adopted: 250ml normal saline is administered within 10 minutes after direct PCI, and the rehydration volume changes to 125ml in patients with mild-to-moderate congestive heart failure. If the increment of SV≥15%, then adjust the rehydration speed to 3 ml/kg/h; if 10%≤the increment of SV\<15%, then adjust the rehydration speed to 2 ml/kg/h; if the increment of SV\<10%, then adjust the rehydration speed to 1 ml/kg/h. Reassessed every 1 hour until SV is stable，and the hydration also lasts 24 hours after operation.
the control group
The routine hydration regimen is adopted, perioperative saline ≤500 ml hydration
No interventions assigned to this group
Interventions
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the adequate hydration group guided by Vigileo
If the patient is mechanically ventilated, the following scheme is adopted: if SVV≤10%, then adjust the rehydration speed to 1 ml/kg/h; if 10%\<SVV\<15%, then adjust the rehydration speed to 2 ml/kg/h; if SVV≥15%, then adjust the rehydration speed to 3 ml/kg/h. The hydration lasts 24 hours after operation, and the rehydration speed is changed according to the SVV. If the patient does not use mechanical ventilation, the following scheme is adopted: 250ml normal saline is administered within 10 minutes after direct PCI, and the rehydration volume changes to 125ml in patients with mild-to-moderate congestive heart failure. If the increment of SV≥15%, then adjust the rehydration speed to 3 ml/kg/h; if 10%≤the increment of SV\<15%, then adjust the rehydration speed to 2 ml/kg/h; if the increment of SV\<10%, then adjust the rehydration speed to 1 ml/kg/h. Reassessed every 1 hour until SV is stable，and the hydration also lasts 24 hours after operation.
Eligibility Criteria
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Inclusion Criteria
* Patients aged 18-80 years
* Patients are scheduled to undergo emergency percutaneous coronary interventions
* Estimated glomerular filtration rate eGFR \<120ml / min (according to MDRD formula)
* Sign the informed consent to join the group.
Exclusion Criteria
* Patients with cardiogenic shock
* Patients with aortic dissection
* Patients who have malignant tumors or short-term progressive diseases that researchers believe improper to be included in the group
* Hemodialysis-dependent patients with end-stage renal failure
* Patients who had a history of exposure to radioactive contrast media within 1 week before or 72 hours after direct PCI
* Patients who are allergic to radioactive contrast agents
* Patients diagnosed with right ventricular myocardial infarction with hypotension (defined as systolic blood pressure ≤90 mmHg) on admission.
18 Years
80 Years
ALL
No
Sponsors
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Lu jiang hospital
UNKNOWN
Chinese PLA General Hospital
OTHER
Responsible Party
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Qian geng
Clinical Professor
Locations
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Chinese People's Liberation Army General Hospital
Beijing, Beijing Municipality, China
Countries
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References
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Other Identifiers
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sf2020-2-5012
Identifier Type: -
Identifier Source: org_study_id
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