Development of Cellular Models for Osteoblast Response Study to Adipocytic Secretions in an Osteoporosis Context.

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Total Enrollment

20 participants

Study Classification

OBSERVATIONAL

Study Start Date

2020-10-15

Study Completion Date

2024-09-04

Brief Summary

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The recent studies suggest that secretions from medullary adipocytes are involved in the mechanisms of bone loss in osteoporosis (OP) through their actions on neighbouring osteoforming cells, the osteoblasts. The objective of the research is the development of new cellular models representing the aging skeleton to confirm this hypothesis. To this end, osteoblasts will be isolated from human bone fragments coming from femoral heads discarded during total hip replacement surgery. The osteoblastic response to secreted factors released from medullary adipocytes of commercial origin will be analysed using conditioned media incubations. This phenotypic response will be quantified for each subject through the analysis of gene expression levels. Inter-subject phenotype variations will be related to bone density and microarchitecture data obtained by X-ray microtomography. This will assess the existence of a correlation between the osteoblast response to adipocyte secretions and the degree of osteoporosis of the subject from whom the cells are derived.

Detailed Description

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Conditions

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Osteoporosis

Keywords

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Bone Osteoporosis Osteoblast Adipocyte Cellular models

Study Design

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Observational Model Type

OTHER

Study Time Perspective

PROSPECTIVE

Eligibility Criteria

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Inclusion Criteria

* Adult subject
* Surgical indication for hip prosthesis implantation
* Affiliation to a social insurance regime

Exclusion Criteria

* Rejection of participation
* Diagnosed bone diseases other than osteoarthritis or osteoporosis
* Cancer
* Pregnant Women
* Subject under guardianship or trusteeship
* Subject unable to understand the study.

Minimum Eligible Age

18 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Responsible Party

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Responsibility Role SPONSOR

Principal Investigators

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Eric FODZO, MD

Role: PRINCIPAL_INVESTIGATOR

University Hospital, Lille

Locations

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Centre hospitalier

Boulogne-sur-Mer, , France

Site Status

Countries

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France

Other Identifiers

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2020-A00027-32

Identifier Type: OTHER

Identifier Source: secondary_id

2019_18R

Identifier Type: -

Identifier Source: org_study_id