Effect of Pineapple Juice on the Pharmacokinetics of Celecoxib and Montelukast in Humans
NCT ID: NCT04374981
Last Updated: 2020-05-05
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
24 participants
INTERVENTIONAL
2019-07-01
2019-12-01
Brief Summary
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Detailed Description
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Conditions
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Study Design
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RANDOMIZED
CROSSOVER
TREATMENT
NONE
Study Groups
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Celecoxib
Twelve healthy male subjects participated in this arm under fasting condition. A randomized, open-label, 2-way crossover study design with 2-week washout period between treatments was used. Participants received a single oral dose of celecoxib tablets (100mg) after pre-treatment with 250ml of either pineapple juice or water (control) for four consecutive days before the beginning of the study.
Celecoxib 100mg
Tablets
Montelukast
Twelve healthy male subjects participated in this arm under fasting condition. A randomized, open-label, 2-way crossover study design with 2-week washout period between treatments was used. Participants received a single oral dose of Montelukast tablets (10mg) after pre-treatment with 250ml of either pineapple juice or water (control) for four consecutive days before the beginning of the study.
Montelukast 10mg
Tablets
Interventions
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Celecoxib 100mg
Tablets
Montelukast 10mg
Tablets
Eligibility Criteria
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Inclusion Criteria
Exclusion Criteria
* Drug abuse.
* Abnormal level of kidney or liver functions.
18 Years
40 Years
MALE
Yes
Sponsors
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Damanhour University
OTHER
Responsible Party
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Sally Helmy, PhD, CPHQ
Associate professor
Principal Investigators
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Sally Helmy, PhD
Role: PRINCIPAL_INVESTIGATOR
Damanhour University
Locations
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Faculty of Pharmacy-Damanhour University.
Damanhūr, , Egypt
Countries
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Other Identifiers
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CMP
Identifier Type: -
Identifier Source: org_study_id
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