Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Naso- Pharyngeal Viral Load in Patients With COVID-19
NCT ID: NCT04371965
Last Updated: 2020-10-26
Study Results
The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.
Basic Information
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COMPLETED
PHASE2
24 participants
INTERVENTIONAL
2020-09-01
2020-10-23
Brief Summary
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24 patients with positive nasopharyngeal SARS-CoV-2 carriage will be randomized (1:1) in an experimental group (benefiting from povidone iodine decolonization) or a control group. Patients in the experimental group will be asked to gargle with a 1% povidone-iodine solution, spray their nose with the same antiseptic solution, and finally applied 10% povidone-iodine cream in each nostril, all four times a day for five days. Patients will be followed for 7 days to evaluate the efficacy and safety of povidone iodine decolonization.
Detailed Description
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Conditions
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Study Design
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RANDOMIZED
PARALLEL
TREATMENT
NONE
Study Groups
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Decolonization
1% Povidone iodine mouthwash (95 mL), gargle, and nasal spray (2,5 mL by nostril), and 10% nasal gel (one drop). All four time a day for five days.
Povidone-Iodine
Patients in the experimental group will be asked to gargle with a 1% povidone-iodine solution, spray their nose with the same antiseptic solution, and finally applied 10% povidone-iodine cream in each nostril, all four times a day for five days.
Control
Absence of local decolonization
No interventions assigned to this group
Interventions
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Povidone-Iodine
Patients in the experimental group will be asked to gargle with a 1% povidone-iodine solution, spray their nose with the same antiseptic solution, and finally applied 10% povidone-iodine cream in each nostril, all four times a day for five days.
Eligibility Criteria
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Inclusion Criteria
* With positive SARS-CoV-2 carriage by RT-PCR
* Having given their written consent after having been informed
Exclusion Criteria
* Patient unable to perform oro-nasopharyngeal decolonization
* Known hypersensitivity to one of the constituents, particularly to povidone-iodine,
* History of dysthyroidism,
* Known coagulopathy,
* Participation in another clinical trial aimed at reducing viral load in patients with SARS-CoV-2,
* Pregnant or breastfeeding women, or women of childbearing age without effective contraception
* Patients not covered by a social security scheme
* Patients with enhanced protection
18 Years
ALL
No
Sponsors
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Poitiers University Hospital
OTHER
Responsible Party
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Locations
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University Hospital of Poitiers
Poitiers, , France
Countries
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References
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Guenezan J, Garcia M, Strasters D, Jousselin C, Leveque N, Frasca D, Mimoz O. Povidone Iodine Mouthwash, Gargle, and Nasal Spray to Reduce Nasopharyngeal Viral Load in Patients With COVID-19: A Randomized Clinical Trial. JAMA Otolaryngol Head Neck Surg. 2021 Apr 1;147(4):400-401. doi: 10.1001/jamaoto.2020.5490.
Other Identifiers
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KILLER
Identifier Type: -
Identifier Source: org_study_id