Hydroxychloroquine and Zinc With Either Azithromycin or Doxycycline for Treatment of COVID-19 in Outpatient Setting

NCT ID: NCT04370782

Last Updated: 2020-12-09

Study Results

Results pending

The study team has not published outcome measurements, participant flow, or safety data for this trial yet. Check back later for updates.

Basic Information

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Recruitment Status

COMPLETED

Clinical Phase

PHASE4

Total Enrollment

18 participants

Study Classification

INTERVENTIONAL

Study Start Date

2020-04-28

Study Completion Date

2020-09-30

Brief Summary

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This is a randomized, open-label trial to assess the safety and efficacy of hydroxychloroquine, and zinc in combination with either azithromycin or doxycycline in a higher risk COVID-19 positive outpatient population.

Detailed Description

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COVID-19 is an aggressive and contagious virus, found to have high mortality especially in persons with comorbidities (Age\>60, hypertension \[HTN\], diabetes mellitus \[DM\], Cancer, and otherwise immunocompromised). Zinc is a supplement with possible antiviral properties, having been shown to have effect in the common cold, many of which are due to coronavirus. In addition, elderly patients and patients with co-morbidities have high incidence of zinc deficiency. We are repleting zinc in all patients and studying its direct effect in combination with hydroxychloroquine, and an antibiotic, either azithromycin or doxycycline to see if there is enhanced treatment efficacy in early COVID-19 infection and assess the safety of these two regimen.

Conditions

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COVID-19

Keywords

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coronavirus hydroxychloroquine zinc sulfate

Study Design

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Allocation Method

RANDOMIZED

Intervention Model

PARALLEL

Primary Study Purpose

TREATMENT

Blinding Strategy

NONE

Study Groups

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Experimental Arm 1

Hydroxychloroquine

Azithromycin

Zinc sulfate

Group Type EXPERIMENTAL

Hydroxychloroquine

Intervention Type DRUG

Hydroxychloroquine 400mg twice a day (BID) on day 1, followed by 200mg BID for days 2-5

Azithromycin

Intervention Type DRUG

Azithromycin 500mg on day 1, followed by 250mg once daily for days 2-5

Zinc Sulfate

Intervention Type DRUG

Zinc sulfate 220mg once daily for 5 days

Experimental Arm 2

Hydroxychloroquine

Doxycycline

Zinc sulfate

Group Type EXPERIMENTAL

Hydroxychloroquine

Intervention Type DRUG

Hydroxychloroquine 400mg twice a day (BID) on day 1, followed by 200mg BID for days 2-5

Zinc Sulfate

Intervention Type DRUG

Zinc sulfate 220mg once daily for 5 days

Doxycycline

Intervention Type DRUG

Doxycycline 200 mg once daily for 5 days

Interventions

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Hydroxychloroquine

Hydroxychloroquine 400mg twice a day (BID) on day 1, followed by 200mg BID for days 2-5

Intervention Type DRUG

Azithromycin

Azithromycin 500mg on day 1, followed by 250mg once daily for days 2-5

Intervention Type DRUG

Zinc Sulfate

Zinc sulfate 220mg once daily for 5 days

Intervention Type DRUG

Doxycycline

Doxycycline 200 mg once daily for 5 days

Intervention Type DRUG

Eligibility Criteria

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Inclusion Criteria

* Able to read and understand informed consent.
* High initial clinical suspicion by physician based on signs and symptoms (fever, cough, myalgias, fatigue, shortness of breath) followed by RT-PCR for confirmation of COVID-19 diagnosis
* Any gender
* Age 60 years and older
* Age 30-59 years with one or more of the following:

* abnormal lung exam
* abnormal oxygen staturation \<95%
* abnormal chest x-ray or chest CT
* persistent fever \>100.4 degrees Fahrenheit upon arrival to Emergency department (ED)
* one of the following co-morbidities: hypertension, diabetes mellitus, history of coronary artery disease, chronic kidney disease (CKD), asthma, chronic obstructive pulmonary disease, current or former smoker, or morbid obesity (Body Mass Index ≥35)

Exclusion Criteria

* Pregnant or breastfeeding female
* Severe COVID-19 requiring admission for inpatient treatment
* Need for any oxygen supplementation
* Need for mechanical ventilatory support
* History of oxygen supplementation dependency
* History of cancer with ongoing chemotherapy or radiation therapy
* Concurrent antimicrobial therapy
* Known hypersensitivity to hydroxychloroquine or other 4-aminoquinoline compounds
* Already taking hydroxychloroquine or chloroquine within 1 month
* Known G6-PD deficiency
* History of retinopathy
* History of current cardiac diseases (heart failure, ventricular arrhythmias, Left bundle branch block and/or Right bundle branch block, QTc prolongation \>480ms), or family history of sudden cardiac death
* Ongoing use of drugs that prolong the QTc interval (antipsychotics, antidepressants, class I and III antiarrhythmics, triptans)
* Severe renal disease: glomerular filtration rate (GFR) \<30ml/min
* Severe hepatic impairment (elevated total bilirubin \>2 mg/dL, decreased albumin \<2.8 g/dL, signs of jaundice and ascites.)
* Active alcohol abuse (\>5 drinks per day or \>20 drinks per week.)
* Seizure disorder, currently on medications
* Known hypersensitivity to any tetracyclines.
Minimum Eligible Age

30 Years

Eligible Sex

ALL

Accepts Healthy Volunteers

No

Sponsors

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St. Francis Hospital, New York

OTHER

Sponsor Role lead

Responsible Party

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Avni Thakore MD

Principal Investigator

Responsibility Role PRINCIPAL_INVESTIGATOR

Principal Investigators

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Avni Thakore, MD

Role: PRINCIPAL_INVESTIGATOR

Saint Francis Hospital

Locations

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St Francis Hospital

Roslyn, New York, United States

Site Status

Countries

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United States

References

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Reference Type BACKGROUND
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Other Identifiers

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20-21

Identifier Type: -

Identifier Source: org_study_id